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Advanced Search Results For "Halpin, Anthony"

1 - 10 of 113 results for
 "Halpin, Anthony"
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Paediatric COVID-19 mortality: a database analysis of the impact of health resource disparity

Publication Type: Academic Journal

Source(s): BMJ Paediatrics Open, Vol 6, Iss 1 (2022)

Abstract: Background The impact of the COVID-19 pandemic on paediatric populations varied between high-income countries (HICs) versus low-income to middle-income countries (LMICs). We sought to investigate differences in paediatric clinical outcomes and identify...

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Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study

Publication Type: Academic Journal

Source(s): The Lancet: Digital Health, Vol 4, Iss 4, Pp e220-e234 (2022)

Abstract: Summary: Background: Dexamethasone was the first intervention proven to reduce mortality in patients with COVID-19 being treated in hospital. We aimed to evaluate the adoption of corticosteroids in the treatment of COVID-19 in the UK after the RECOVERY...

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The impact of viral mutations on recognition by SARS-CoV-2 specific T cells

Publication Type: Academic Journal

Source(s): iScience, Vol 24, Iss 11, Pp 103353- (2021)

Abstract: Summary: We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of reco...

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Long-term clinical outcomes in survivors of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome coronavirus (MERS) outbreaks after hospitalisation or ICU admission: A systematic review and meta-analysis

Publication Type: Academic Journal

Source(s): Journal of Rehabilitation Medicine, Vol 52, Iss 5, p jrm00063 (2020)

Abstract: Objective: To determine long-term clinical outcomes in survivors of severe acute respiratory syndrome (SARS) and Middle East respiratory syndrome (MERS) coronavirus infections after hospitalization or intensive care unit admission. Data sources: Ovid M...

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Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study

Publication Type: Periodical

Source(s): The Lancet Digital Health; April 2022, Vol. 4 Issue: 4 pe220-e234, 15p

Abstract: Dexamethasone was the first intervention proven to reduce mortality in patients with COVID-19 being treated in hospital. We aimed to evaluate the adoption of corticosteroids in the treatment of COVID-19 in the UK after the RECOVERY trial publication on...

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The effective rate of influenza reassortment is limited during human infection.

Publication Type: Academic Journal

Source(s): PLoS Pathogens, Vol 13, Iss 2, p e1006203 (2017)

Abstract: We characterise the evolutionary dynamics of influenza infection described by viral sequence data collected from two challenge studies conducted in human hosts. Viral sequence data were collected at regular intervals from infected hosts. Changes in the...

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Characterisation of in-hospital complications associated with COVID-19 using the ISARIC WHO Clinical Characterisation Protocol UK: a prospective, multicentre cohort study

Publication Type: Periodical

Source(s): The Lancet; July 2021, Vol. 398 Issue: 10296 p223-237, 15p

Abstract: COVID-19 is a multisystem disease and patients who survive might have in-hospital complications. These complications are likely to have important short-term and long-term consequences for patients, health-care utilisation, health-care system preparedne...

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Changes in in-hospital mortality in the first wave of COVID-19: a multicentre prospective observational cohort study using the WHO Clinical Characterisation Protocol UK

Publication Type: Periodical

Source(s): The Lancet Respiratory Medicine; July 2021, Vol. 9 Issue: 7 p773-785, 13p

Abstract: Mortality rates in hospitalised patients with COVID-19 in the UK appeared to decline during the first wave of the pandemic. We aimed to quantify potential drivers of this change and identify groups of patients who remain at high risk of dying in hospital.

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Risk of adverse outcomes in patients with underlying respiratory conditions admitted to hospital with COVID-19: a national, multicentre prospective cohort study using the ISARIC WHO Clinical Characterisation Protocol UK

Publication Type: Periodical

Source(s): The Lancet Respiratory Medicine; July 2021, Vol. 9 Issue: 7 p699-711, 13p

Abstract: Studies of patients admitted to hospital with COVID-19 have found varying mortality outcomes associated with underlying respiratory conditions and inhaled corticosteroid use. Using data from a national, multicentre, prospective cohort, we aimed to char...

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Development and validation of the ISARIC 4C Deterioration model for adults hospitalised with COVID-19: a prospective cohort study

Publication Type: Periodical

Source(s): The Lancet Respiratory Medicine; April 2021, Vol. 9 Issue: 4 p349-359, 11p

Abstract: Prognostic models to predict the risk of clinical deterioration in acute COVID-19 cases are urgently required to inform clinical management decisions.

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