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Advanced Search Results For "Harrison, David M."

1 - 10 of 5,736 results for
 "Harrison, David M."
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Isolevuglandins disrupt PU.1-mediated C1q expression and promote autoimmunity and hypertension in systemic lupus erythematosus

Publication Type:Academic Journal

Source(s):JCI Insight, Vol 7, Iss 13 (2022)

Abstract:We describe a mechanism responsible for systemic lupus erythematosus (SLE). In humans with SLE and in 2 SLE murine models, there was marked enrichment of isolevuglandin-adducted proteins (isoLG adducts) in monocytes and dendritic cells. We found that a...

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Can we model cultural ecosystem services, and are we measuring the right things?

Publication Type:Academic Journal

Source(s):People and Nature, Vol 4, Iss 1, Pp 166-179 (2022)

Abstract:Abstract Cultural ecosystem services (CES), a key aspect of nature's contributions to people, remain a challenge to incorporate into decision making. One contributing factor is the difficulty of defining and describing these, due partly to: ongoing poo...

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Coagulation factor IX gene transfer to non-human primates using engineered AAV3 capsid and hepatic optimized expression cassette

Publication Type:Academic Journal

Source(s):Molecular Therapy: Methods & Clinical Development, Vol 23, Iss , Pp 98-107 (2021)

Abstract:Hepatic gene transfer with adeno-associated viral (AAV) vectors shows much promise for the treatment of the X-linked bleeding disorder hemophilia B in multiple clinical trials. In an effort to further innovate this approach and to introduce alternative...

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Deletion of AMPA receptor GluA1 subunit gene (Gria1) causes circadian rhythm disruption and aberrant responses to environmental cues

Publication Type:Academic Journal

Source(s):Translational Psychiatry, Vol 11, Iss 1, Pp 1-17 (2021)

Abstract:Abstract Dysfunction of the glutamate α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor GluA1 subunit and deficits in synaptic plasticity are implicated in schizophrenia and sleep and circadian rhythm disruption. To investigate the r...

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Conversion of Pulse Protein Foam-Templated Oleogels into Oleofoams for Improved Baking Application

Publication Type:Academic Journal

Source(s):Foods, Vol 11, Iss 2887, p 2887 (2022)

Abstract:The food industry has long been searching for an efficient replacement for saturated-fatty-acid-rich fats for baking applications. Although oleogels have been considered a potential alternative for saturated and trans fats, their success in food applic...

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AusTraits, a curated plant trait database for the Australian flora

Publication Type:Academic Journal

Source(s):Scientific Data, Vol 8, Iss 1, Pp 1-20 (2021)

Abstract:Measurement(s) plant trait Technology Type(s) digital curation Sample Characteristic - Organism Viridiplantae Sample Characteristic - Location Australia Machine-accessible metadata file describing the reported data: https://doi.org/10.6084/m9.figshare....

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CLIMB-COVID: continuous integration supporting decentralised sequencing for SARS-CoV-2 genomic surveillance

Publication Type:Academic Journal

Source(s):Genome Biology, Vol 22, Iss 1, Pp 1-21 (2021)

Abstract:Abstract In response to the ongoing SARS-CoV-2 pandemic in the UK, the COVID-19 Genomics UK (COG-UK) consortium was formed to rapidly sequence SARS-CoV-2 genomes as part of a national-scale genomic surveillance strategy. The network consists of univers...

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The impact of viral mutations on recognition by SARS-CoV-2 specific T cells

Publication Type:Academic Journal

Source(s):iScience, Vol 24, Iss 11, Pp 103353- (2021)

Abstract:Summary: We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of reco...

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Activation of Focal Adhesion Kinase Restores Simulated Microgravity-Induced Inhibition of Osteoblast Differentiation via Wnt/Β-Catenin Pathway

Publication Type:Academic Journal

Source(s):International Journal of Molecular Sciences, Vol 23, Iss 5593, p 5593 (2022)

Abstract:Simulated microgravity (SMG) inhibits osteoblast differentiation (OBD) and induces bone loss via the inhibition of the Wnt/β-catenin pathway. However, the mechanism by which SMG alters the Wnt/β-catenin pathway is unknown. We previously demonstrated th...

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Analysing detection gaps in acoustic telemetry data to infer differential movement patterns in fish

Publication Type:Academic Journal

Source(s):Ecology and Evolution, Vol 11, Iss 6, Pp 2717-2730 (2021)

Abstract:Abstract A wide array of technologies are available for gaining insight into the movement of wild aquatic animals. Although acoustic telemetry can lack the fine‐scale spatial resolution of some satellite tracking technologies, the substantially longer ...

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