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Advanced Search Results For "Her�� H"

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 "Her�� H"
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Longitudinal stability of molecular alterations and drug response profiles in tumor spheroid cell lines enables reproducible analyses

Publication Type: Academic Journal

Source(s): Biomedicine & Pharmacotherapy, Vol 144, Iss , Pp 112278- (2021)

Abstract: The utility of patient-derived tumor cell lines as experimental models for glioblastoma has been challenged by limited representation of the in vivo tumor biology and low clinical translatability. Here, we report on longitudinal epigenetic and transcri...

Impact of carboxylesterase 1 genetic polymorphism on trandolapril activation in human liver and the pharmacokinetics and pharmacodynamics in healthy volunteers

Publication Type: Academic Journal

Source(s): Clinical and Translational Science, Vol 14, Iss 4, Pp 1380-1389 (2021)

Abstract: Abstract Trandolapril, an angiotensin‐converting enzyme inhibitor prodrug, needs to be activated by carboxylesterase 1 (CES1) in the liver to exert its intended therapeutic effect. A previous in vitro study demonstrated that the CES1 genetic variant G1...

Voxel-level biological optimisation of prostate IMRT using patient-specific tumour location and clonogen density derived from mpMRI

Publication Type: Academic Journal

Source(s): Radiation Oncology, Vol 15, Iss 1, Pp 1-13 (2020)

Abstract: Abstract Aims This study aimed to develop a framework for optimising prostate intensity-modulated radiotherapy (IMRT) based on patient-specific tumour biology, derived from multiparametric MRI (mpMRI). The framework included a probabilistic treatment p...

Synthesis, Stability, and Biological Studies of Fluorinated Analogues of Thromboxane A2

Publication Type: Academic Journal

Source(s): ACS Central Science, Vol 6, Iss 6, Pp 995-1000 (2020)


The role of HGF-MET pathway and CCDC66 cirRNA expression in EGFR resistance and epithelial-to-mesenchymal transition of lung adenocarcinoma cells

Publication Type: Academic Journal

Source(s): Journal of Hematology & Oncology, Vol 11, Iss 1, Pp 1-14 (2018)

Abstract: Abstract Background Epithelial-to-mesenchymal transition (EMT) has, in recent years, emerged as an important tumor cell behavior associated with high metastatic potential and drug resistance. Interestingly, protein SUMOylation and hepatocyte growth fac...

Retrotransposons Are the Major Contributors to the Expansion of the Drosophila ananassae Muller F Element

Publication Type: Academic Journal

Source(s): G3: Genes, Genomes, Genetics, Vol 7, Iss 8, Pp 2439-2460 (2017)

Abstract: The discordance between genome size and the complexity of eukaryotes can partly be attributed to differences in repeat density. The Muller F element (∼5.2 Mb) is the smallest chromosome in Drosophila melanogaster, but it is substantially larger (>18.7 ...

Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)

Abstract: Flap Endonuclease 1 is a DNA replication and repair enzyme indispensable for maintaining genomic stability. Here the authors provide mechanistic details on how FEN1 selects for 5′-flaps and promotes catalysis to avoid large-scale repeat expansion by a ...


Enhanced Oral Bioavailability of the Pharmacologically Active Lignin Magnolol via Zr-Based Metal Organic Framework Impregnation

Publication Type: Academic Journal

Source(s): Pharmaceutics, Vol 12, Iss 437, p 437 (2020)

Abstract: Bioavailability plays an important role in drug activity in the human body, as certain drug amounts should be present to elicit activity. However, low bioavailability of drugs leads to negligible use for human benefit. In this study, the diversely acti...

The Fos-Related Antigen 1–JUNB/Activator Protein 1 Transcription Complex, a Downstream Target of Signal Transducer and Activator of Transcription 3, Induces T Helper 17 Differentiation and Promotes Experimental Autoimmune Arthritis

Publication Type: Academic Journal

Source(s): Frontiers in Immunology, Vol 8 (2017)

Abstract: Dysfunction of T helper 17 (Th17) cells leads to chronic inflammatory disorders. Signal transducer and activator of transcription 3 (STAT3) orchestrates the expression of proinflammatory cytokines and pathogenic cell differentiation from interleukin (I...