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Epigenetic Alterations of Repeated Relapses in Patient-matched Childhood Ependymomas
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Abstract: While recurrence is frequent in ependymoma, the underlying molecular mechanisms remain to be explored. Here, the authors investigate epigenetic, genetic and tumorigenic changes in 30 patient-matched repeated relapses over 13 years and identify distinct...
Current studies and future directions for medulloblastoma: A review from the pacific pediatric neuro-oncology consortium (PNOC) disease working group
Publication Type: Academic Journal
Source(s): Neoplasia: An International Journal for Oncology Research, Vol 35, Iss , Pp 100861- (2023)
Abstract: Medulloblastoma (MB) is the most common malignant central nervous system tumor of childhood, comprising a heterogenous group of tumors each with distinct biology, clinical behavior, and prognosis. Long-term survival remains unacceptable, and those who ...
Synergistic anti-tumor efficacy of mutant isocitrate dehydrogenase 1 inhibitor SYC-435 with standard therapy in patient-derived xenograft mouse models of glioma
Publication Type: Academic Journal
Source(s): Translational Oncology, Vol 18, Iss , Pp 101368- (2022)
Abstract: Clinical outcomes in patients with WHO grade II/III astrocytoma, oligodendroglioma or secondary glioblastoma remain poor. Isocitrate dehydrogenase 1 (IDH1) is mutated in > 70% of these tumors, making it an attractive therapeutic target. To determine th...
Spatial Dissection of Invasive Front from Tumor Mass Enables Discovery of Novel microRNA Drivers of Glioblastoma Invasion
Publication Type: Academic Journal
Source(s): Advanced Science, Vol 8, Iss 23, Pp n/a-n/a (2021)
Abstract: Abstract Diffuse invasion is the primary cause of treatment failure of glioblastoma (GBM). Previous studies on GBM invasion have long been forced to use the resected tumor mass cells. Here, a strategy to reliably isolate matching pairs of invasive (GBM...
The Vermont Family Based Approach in Primary Care Pediatrics: Effects on Children's and Parents' Emotional and Behavioral Problems and Parents' Health-Related Quality of Life.
Publication Type: Academic Journal
Source(s): Child Psychiatry & Human Development; Oct2023, Vol. 54 Issue 5, p1297-1308, 12p, 1 Diagram, 1 Chart
Abstract: Copyright of Child Psychiatry & Human Development is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may pr...
Examining the association of clinician characteristics with perceived changes in cervical cancer screening and colposcopy practice during the COVID-19 pandemic: a mixed methods assessment.
Publication Type: Academic Journal
Source(s): eLife. 9/1/2023, p1-17. 17p.
Abstract: Background: The COVID-19 pandemic led to reductions in cervical cancer screening and colposcopy. Therefore, in this mixed method study we explored perceived pandemic-related practice changes to cervical cancer screenings and colposcopies. Methods: In 2...
Patient-Derived Orthotopic Xenograft (PDOX) Mouse Models of Primary and Recurrent Meningioma
Publication Type: Academic Journal
Source(s): Cancers, Vol 12, Iss 1478, p 1478 (2020)
Abstract: Background. Meningiomas constitute one-third of all primary brain tumors. Although typically benign, about 20% of these tumors recur despite surgery and radiation, and may ultimately prove fatal. There are currently no effective chemotherapies for meni...
MAPK pathway-targeted therapies for pediatric low grade gliomas
Publication Type: Academic Journal
Source(s): Pediatric Hematology Oncology Journal, Vol 8, Iss 2, Pp 97-101 (2023)
Abstract: The most common pathologic group of childhood brain tumors are low grade gliomas (LGG). LGG comprise a variety of histologies among which pilocytic astrocytoma (WHO grade I) is the most common. Complete resection of LGG portends an excellent prognosis,...
Examining the perceived impact of the COVID-19 pandemic on cervical cancer screening practices among clinicians practicing in Federally Qualified Health Centers: A mixed methods study
Publication Type: Academic Journal
Source(s): eLife, Vol 12 (2023)
Abstract: Background: The COVID-19 pandemic led to reductions in cervical cancer screening and colposcopy. Therefore, in this mixed methods study we explored perceived pandemic-related practice changes to cervical cancer screenings in federally qualified health ...
Examining the association of clinician characteristics with perceived changes in cervical cancer screening and colposcopy practice during the COVID-19 pandemic: a mixed methods assessment
Publication Type: Academic Journal
Source(s): eLife, Vol 12 (2023)
Abstract: Background: The COVID-19 pandemic led to reductions in cervical cancer screening and colposcopy. Therefore, in this mixed method study we explored perceived pandemic-related practice changes to cervical cancer screenings and colposcopies. Methods: In 2...