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Advanced Search Results For "Holman, Richard L."

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 "Holman, Richard L."
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The effect of perennial and annual wheat forages, fed with or without lucerne, on the fatty acid profile and oxidative status of lamb meat

Publication Type:Academic Journal

Source(s):Veterinary and Animal Science, Vol 15, Iss , Pp 100230- (2022)

Abstract:The current study investigated the fatty acid profile and oxidative status of the meat from lambs that were fed a novel perennial wheat or a conventional annual wheat, either as a cereal monoculture or lucerne biculture. Twelve lambs were assigned to e...

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Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)

Abstract:Known genetic loci account for only a fraction of the genetic contribution to Alzheimer’s disease. Here, the authors have performed a large genome-wide meta-analysis comprising 409,435 individuals to discover 6 new loci and demonstrate the efficacy of ...

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Genetic Overlap Between Alzheimer’s Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes

Publication Type:Academic Journal

Source(s):Frontiers in Neuroscience, Vol 13 (2019)

Abstract:Background: Alzheimer’s disease (AD) and bipolar disorder (BIP) are complex traits influenced by numerous common genetic variants, most of which remain to be detected. Clinical and epidemiological evidence suggest that AD and BIP are related. However, ...

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Safety and pharmacokinetics of the Fc-modified HIV-1 human monoclonal antibody VRC01LS: A Phase 1 open-label clinical trial in healthy adults.

Publication Type:Academic Journal

Source(s):PLoS Medicine, Vol 15, Iss 1, p e1002493 (2018)

Abstract:BACKGROUND:VRC01 is a human broadly neutralizing monoclonal antibody (bnMAb) against the CD4-binding site of the HIV-1 envelope glycoprotein (Env) that is currently being evaluated in a Phase IIb adult HIV-1 prevention efficacy trial. VRC01LS is a modi...

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Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease.

Publication Type:Academic Journal

Source(s):PLoS ONE, Vol 9, Iss 6, p e94661 (2014)

Abstract:BACKGROUND:Alzheimer's disease is a common debilitating dementia with known heritability, for which 20 late onset susceptibility loci have been identified, but more remain to be discovered. This study sought to identify new susceptibility genes, using ...

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Genetic evidence implicates the immune system and cholesterol metabolism in the aetiology of Alzheimer's disease.

Publication Type:Academic Journal

Source(s):PLoS ONE, Vol 5, Iss 11, p e13950 (2010)

Abstract:BackgroundLate Onset Alzheimer's disease (LOAD) is the leading cause of dementia. Recent large genome-wide association studies (GWAS) identified the first strongly supported LOAD susceptibility genes since the discovery of the involvement of APOE in th...

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A comparison of four clustering methods for brain expression microarray data

Publication Type:Academic Journal

Source(s):BMC Bioinformatics, Vol 9, Iss 1, p 490 (2008)

Abstract:Abstract Background DNA microarrays, which determine the expression levels of tens of thousands of genes from a sample, are an important research tool. However, the volume of data they produce can be an obstacle to interpretation of the results. Cluste...

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When in Rome...

Publication Type:Periodical

Source(s):Forbes. 10/26/1992, Vol. 150 Issue 10, p30-30. 1p.

Abstract:The article reports that about 9000 public bath houses in Japan have introduced posters in eight languages, explaining bathing etiquette to a growing number of foreign guests. It is reported that some foreigners had earlier entered the water wearing un...

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