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Correlation between antibiotic consumption and resistance of Pseudomonas aeruginosa in a teaching hospital implementing an antimicrobial stewardship program: A longitudinal observational study
Publication Type: Academic Journal
Source(s): Journal of Microbiology, Immunology and Infection, Vol 56, Iss 2, Pp 337-343 (2023)
Abstract: Background/purpose: The rapid emergence of Pseudomonas aeruginosa resistance made selecting antibiotics more challenge. Antimicrobial stewardship programs (ASPs) are urging to implant to control the P. aeruginosa resistance. The purpose of this study i...
Expansion of interferon inducible gene pool via USP18 inhibition promotes cancer cell pyroptosis
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 14, Iss 1, Pp 1-22 (2023)
Abstract: The induction of immunogenic cell death (ICD) can potentiate antitumour immunity. Here the authors show that USP18, a negative regulator of IFN signaling protects cancer cells from ICD by suppressing the expression of canonical and non-canonical IFN-st...
Neutralization sensitivity, fusogenicity, and infectivity of Omicron subvariants
Publication Type: Academic Journal
Source(s): Genome Medicine, Vol 14, Iss 1, Pp 1-13 (2022)
Abstract: Abstract Background The emergence of SARS-CoV-2 Omicron subvariants has raised questions regarding resistance to immunity by natural infection or immunization. We examined the sensitivity of Delta and Omicron subvariants (BA.1, BA.1.1, BA.2, BA.2.12.1,...
CT-based radiogenomic analysis dissects intratumor heterogeneity and predicts prognosis of colorectal cancer: a multi-institutional retrospective study
Publication Type: Academic Journal
Source(s): Journal of Translational Medicine, Vol 20, Iss 1, Pp 1-12 (2022)
Abstract: Abstract Background This study aimed to develop a radiogenomic prognostic prediction model for colorectal cancer (CRC) by investigating the biological and clinical relevance of intratumoural heterogeneity. Methods This retrospective multi-cohort study ...
Traditional Chinese Manual Therapy (Tuina) reshape the function of default mode network in patients with lumbar disc herniation
Publication Type: Academic Journal
Source(s): Frontiers in Neuroscience, Vol 17 (2023)
Abstract: PurposeInvestigating the changes of regional homogeneity (ReHo) values and both static and dynamic functional connectivity (FC) before and after Traditional Chinese Manual Therapy (Tuina) in patients with lumbar disk herniation (LDH) through resting-st...
Extending the dosing interval of COVID-19 vaccination leads to higher rates of seroconversion in people living with HIV
Publication Type: Academic Journal
Source(s): Frontiers in Immunology, Vol 14 (2023)
Abstract: IntroductionVaccination against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection is an effective way of protecting individuals from severe coronavirus disease 2019 (COVID-19). However, immune responses to vaccination vary consider...
Durability of neutralization against Omicron subvariants after vaccination and breakthrough infection
Publication Type: Academic Journal
Source(s): Cell Reports, Vol 42, Iss 2, Pp 112075- (2023)
Abstract: Summary: Booster immunizations and breakthrough infections can elicit severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariant neutralizing activity. However, the durability of the neutralization response is unknown. We character...
An extended 36-week oral esomeprazole improved long-term recurrent peptic ulcer bleeding in patients at high risk of rebleeding
Publication Type: Academic Journal
Source(s): BMC Gastroenterology, Vol 22, Iss 1, Pp 1-12 (2022)
Abstract: Abstract Background Patients with Rockall scores ≥6 have an increased risk of long-term peptic ulcer rebleeding. This study was aimed toward investigating whether an extended course of oral esomeprazole up to 1 year decreased ulcer rebleeding in such p...
SARS-CoV-2 nucleocapsid protein triggers hyperinflammation via protein-protein interaction-mediated intracellular Cl− accumulation in respiratory epithelium
Publication Type: Academic Journal
Source(s): Signal Transduction and Targeted Therapy, Vol 7, Iss 1, Pp 1-13 (2022)
Abstract: Abstract SARS-CoV-2, the culprit pathogen of COVID-19, elicits prominent immune responses and cytokine storms. Intracellular Cl− is a crucial regulator of host defense, whereas the role of Cl− signaling pathway in modulating pulmonary inflammation asso...
Healthcare preferences of the general Chinese population in the hierarchical medical system: A discrete choice experiment
Publication Type: Academic Journal
Source(s): Frontiers in Public Health, Vol 10 (2022)
Abstract: BackgroundChinese health insurance system faces resource distribution challenges. A patient-centric approach allows decision-makers to be keenly aware of optimized medical resource allocation.ObjectiveThis study aims to use the discrete choice model to...