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Advanced Search Results For "Hudson, David"

1 - 10 of 5,077 results for
 "Hudson, David"
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Identifying colorectal cancer caused by biallelic MUTYH pathogenic variants using tumor mutational signatures

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)

Abstract:Germline biallelic pathogenic MUTYH variants predispose patients to colorectal cancer (CRC); however, approaches to identify MUTYH variant carriers are lacking. Here, the authors evaluated mutational signatures that could distinguish MUTYH carriers in ...

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Microvascular stabilization via blood-brain barrier regulation prevents seizure activity

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)

Abstract:The mechanisms underlying epilepsy development are not well understood. Here the authors show that loss of a key component of the so called blood-brain barrier drives seizures in mice and is also lost in humans with treatment resistant epilepsy

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The relationship between the epigenetic aging biomarker “grimage” and lung function in both the airway and blood of people living with HIV: An observational cohort study

Publication Type:Academic Journal

Source(s):EBioMedicine, Vol 83, Iss , Pp 104206- (2022)

Abstract:Summary: Background: Age-related comorbidities such as chronic obstructive pulmonary disease (COPD) are common in people living with human immunodeficiency virus (PLWH). We investigated the relationship between COPD and the epigenetic age of the airway...

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Influence of Rising Water Temperature on the Temperate Seagrass Species Eelgrass (Zostera marina L.) in the Northeast USA

Publication Type:Academic Journal

Source(s):Frontiers in Marine Science, Vol 9 (2022)

Abstract:Sea surface temperature (SST) has increased worldwide since the beginning of the 20th century, a trend which is expected to continue. Changes in SST can have significant impacts on marine biota, including population-level shifts and alterations in comm...

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Small molecule SWELL1 complex induction improves glycemic control and nonalcoholic fatty liver disease in murine Type 2 diabetes

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 13, Iss 1, Pp 1-25 (2022)

Abstract:Type 2 diabetes is associated with insulin resistance, impaired insulin secretion and liver steatosis. Here the authors report a proof-of-concept study for small molecule SWELL1 modulators as a therapeutic approach to treat diabetes and associated live...

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Implementability of healthcare interventions: an overview of reviews and development of a conceptual framework

Publication Type:Academic Journal

Source(s):Implementation Science, Vol 17, Iss 1, Pp 1-20 (2022)

Abstract:Abstract Background Implementation research may play an important role in reducing research waste by identifying strategies that support translation of evidence into practice. Implementation of healthcare interventions is influenced by multiple factors...

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Neurologic Manifestations of Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Hospitalized Patients During the First Year of the COVID-19 Pandemic

Publication Type:Academic Journal

Source(s):Critical Care Explorations, Vol 4, Iss 4, p e0686 (2022)

Abstract:OBJECTIVES:. To describe the prevalence, associated risk factors, and outcomes of serious neurologic manifestations (encephalopathy, stroke, seizure, and meningitis/encephalitis) among patients hospitalized with severe acute respiratory syndrome corona...

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Sex Modulates the Pathological Aging Effect on Caudate Functional Connectivity in Mild Cognitive Impairment

Publication Type:Academic Journal

Source(s):Frontiers in Psychiatry, Vol 13 (2022)

Abstract:PurposeTo assess the pathological aging effect on caudate functional connectivity among mild cognitive impairment (MCI) participants and examine whether and how sex and amyloid contribute to this process.Materials and MethodsTwo hundred and seventy-sev...

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Antimicrobial resistance in dairy slurry tanks: A critical point for measurement and control

Publication Type:Academic Journal

Source(s):Environment International, Vol 169, Iss , Pp 107516- (2022)

Abstract:Waste from dairy production is one of the largest sources of contamination from antimicrobial resistant bacteria (ARB) and genes (ARGs) in many parts of the world. However, studies to date do not provide necessary evidence to inform antimicrobial resis...

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A comparison of methods to harmonize cortical thickness measurements across scanners and sites

Publication Type:Academic Journal

Source(s):NeuroImage, Vol 261, Iss , Pp 119509- (2022)

Abstract:Results of neuroimaging datasets aggregated from multiple sites may be biased by site-specific profiles in participants’ demographic and clinical characteristics, as well as MRI acquisition protocols and scanning platforms. We compared the impact of fo...

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