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Evidence for reduced BRCA2 functional activity in Homo sapiens after divergence from the chimpanzee-human last common ancestor
Publication Type: Academic Journal
Source(s): Cell Reports, Vol 39, Iss 5, Pp 110771- (2022)
Abstract: Summary: We performed a comparative analysis of human and 12 non-human primates to identify sequence variations in known cancer genes. We identified 395 human-specific fixed non-silent substitutions that emerged during evolution of human. Using bioinfo...
Pancreatic cancer prognosis is predicted by an ATAC-array technology for assessing chromatin accessibility
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Abstract: ATAC-seq allows for the investigation of chromatin accessibility, a feature which can have important implications for gene regulation. Here the authors present ATAC-array to assess accessibility in human tumours and based on this predict disease progno...
Metastatic progression is associated with dynamic changes in the local microenvironment
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 7, Iss 1, Pp 1-9 (2016)
Abstract: Metastatic colonization—the growth of single metastatic cells or small lesions into gross metastases—is poorly understood. Here, the authors characterize the natural history of metastatic growth and assess the impact of chemotherapy in an autochthonous...
The mutational landscape of human somatic and germline cells
Publication Type: Periodical
Source(s): Nature; September 2021, Vol. 597 Issue: 7876 p381-386, 6p
Abstract: Over the course of an individual’s lifetime, normal human cells accumulate mutations1. Here we compare the mutational landscape in 29 cell types from the soma and germline using multiple samples from the same individuals. Two ubiquitous mutational sign...
Early-Onset Pancreas Cancer: Clinical Descriptors, Genomics, and Outcomes.
Publication Type: Academic Journal
Source(s): JNCI: Journal of the National Cancer Institute; Sep2021, Vol. 113 Issue 9, p1194-1202, 9p
Abstract: Copyright of JNCI: Journal of the National Cancer Institute is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permissio...
A six-gene signature predicts survival of patients with localized pancreatic ductal adenocarcinoma.
Publication Type: Academic Journal
Source(s): PLoS Medicine, Vol 7, Iss 7, p e1000307 (2010)
Abstract: Pancreatic ductal adenocarcinoma (PDAC) remains a lethal disease. For patients with localized PDAC, surgery is the best option, but with a median survival of less than 2 years and a difficult and prolonged postoperative course for most, there is an urg...
Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence.
Publication Type: Academic Journal
Source(s): Proceedings of the National Academy of Sciences of the United States of America; Oct2019, Vol. 116 Issue 41, p20482-20488, 7p
Abstract: Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright ho...
The mutational landscape of normal human endometrial epithelium
Publication Type: Periodical
Source(s): Nature; April 2020, Vol. 580 Issue: 7805 p640-646, 7p
Abstract: All normal somatic cells are thought to acquire mutations, but understanding of the rates, patterns, causes and consequences of somatic mutations in normal cells is limited. The uterine endometrium adopts multiple physiological states over a lifetime a...
Evidence for reduced BRCA2 functional activity in Homo sapiens after divergence from the chimpanzee-human last common ancestor.
Publication Type: Academic Journal
Source(s): Cell Reports; May2022, Vol. 39 Issue 5, pN.PAG-N.PAG, 1p
Abstract: Copyright of Cell Reports is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email ar...
Smad4 Loss Correlates With Higher Rates of Local and Distant Failure in Pancreatic Adenocarcinoma Patients Receiving Adjuvant Chemoradiation.
Publication Type: Academic Journal
Source(s): Pancreas; Feb2018, Vol. 47 Issue 2, p208-212, 5p