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A population-scale temporal case–control evaluation of COVID-19 disease phenotype and related outcome rates in patients with cancer in England (UKCCP)
Publication Type: Academic Journal
Source(s): Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract: Abstract Patients with cancer are at increased risk of hospitalisation and mortality following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. However, the SARS-CoV-2 phenotype evolution in patients with cancer since 2020 has no...
Effect of storage duration on carprofen concentration measurements in dog plasma
Publication Type: Academic Journal
Source(s): Veterinary Medicine and Science, Vol 9, Iss 5, Pp 2022-2025 (2023)
Abstract: Abstract Background Storage of samples may be necessary prior to testing drug levels in certain study designs; however, the effect of storage duration on measured drug levels is not known for all drugs. Objectives The objective of this study was to eva...
Multi-Round versus Real-Time Delphi survey approach for achieving consensus in the COHESION core outcome set: a randomised trial
Publication Type: Academic Journal
Source(s): Trials, Vol 24, Iss 1, Pp 1-15 (2023)
Abstract: Abstract Background Delphi surveys are commonly used to prioritise critical outcomes in core outcome set (COS) development. This trial aims to compare a three-round (Multi-Round) Delphi (MRD) with a Real-Time Delphi (RTD) in the prioritisation of outco...
Pyrroloquinoline quinone drives ATP synthesis in vitro and in vivo and provides retinal ganglion cell neuroprotection
Publication Type: Academic Journal
Source(s): Acta Neuropathologica Communications, Vol 11, Iss 1, Pp 1-23 (2023)
Abstract: Abstract Retinal ganglion cells are highly metabolically active requiring strictly regulated metabolism and functional mitochondria to keep ATP levels in physiological range. Imbalances in metabolism and mitochondrial mechanisms can be sufficient to in...
A molecular analysis of substituted phenylethylamines as potential microtubule targeting agents through in silico methods and in vitro microtubule-polymerization activity
Publication Type: Academic Journal
Source(s): Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract: Abstract Natural phenethylamines are trace amine neurotransmitters associated with dopamine transmission and related illnesses such Parkinson’s disease, and addiction. Synthetic phenethylamines can have psychoactive and hallucinogenic effects due to th...
Assembly landscape for the bacterial large ribosomal subunit
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract: Abstract Assembly of ribosomes in bacteria is highly efficient, taking ~2-3 min, but this makes the abundance of assembly intermediates very low, which is a challenge for mechanistic understanding. Genetic perturbations of the assembly process create b...
Emergent increase in coral thermal tolerance reduces mass bleaching under climate change
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract: Abstract Recurrent mass bleaching events threaten the future of coral reefs. To persist under climate change, corals will need to endure progressively more intense and frequent marine heatwaves, yet it remains unknown whether their thermal tolerance ca...
Bottlenose dolphins are sensitive to human attentional features, including eye functionality
Publication Type: Academic Journal
Source(s): Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract: Abstract The ability to attribute attentional states to other individuals is a highly adaptive socio-cognitive skill and thus may have evolved in many social species. However, whilst humans excel in this ability, even chimpanzees appear to not accurate...
Hemiarthroplasty versus total shoulder arthroplasty in B2 glenoids with an intact rotator cuff: a long-term matched cohort analysis
Publication Type: Academic Journal
Source(s): JSES Reviews, Reports, and Techniques, Vol 3, Iss 3, Pp 289-294 (2023)
Abstract: Background: Walch B2 glenoids present unique challenges to the shoulder arthroplasty surgeon, particularly in young, active patients who may wish to avoid the restrictions typically associated with an anatomic total shoulder arthroplasty (TSA). Long-te...
Population health and sociodemographic variables as predictors of access to cardiac medicine and surgery in Haiti
Publication Type: Academic Journal
Source(s): Global Health Research and Policy, Vol 8, Iss 1, Pp 1-14 (2023)
Abstract: Abstract Background In Haiti, cardiovascular disease is a leading cause of morbidity and mortality, with congenital and rheumatic heart disease comprising a large portion of disease burden. However, domestic disparities in cardiac care access and their...