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The Effect of Non-Pharmacological and Pharmacological Interventions on Measures Associated with Sarcopenia in End-Stage Kidney Disease: A Systematic Review and Meta-Analysis
Publication Type: Academic Journal
Source(s): Nutrients, Vol 14, Iss 1817, p 1817 (2022)
Abstract: This systematic review and meta-analysis provides a synthesis of the available evidence for the effects of interventions on outcome measures associated with sarcopenia in end-stage kidney disease (ESKD). Thirteen databases were searched, supplemented w...
Circulating sex hormone binding globulin levels are modified with intensive lifestyle intervention, but their changes did not independently predict diabetes risk in the Diabetes Prevention Program
Publication Type: Academic Journal
Source(s): BMJ Open Diabetes Research & Care, Vol 8, Iss 2 (2020)
Abstract: Introduction Sex hormone binding globulin (SHBG) levels are reported to be inversely associated with diabetes risk. It is unknown whether diabetes prevention interventions increase SHBG and whether resultant changes in SHBG affect diabetes risk. The pu...
Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract: The spatial and frontal QRS-T angles are electrocardiographic (ECG) predictors for arrhythmia. This work used genetic analyses to identify associated loci and pathways, and explore their relationships with other ECG traits and cardiovascular disease.
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Publication Type: Academic Journal
Source(s): Genome Biology, Vol 23, Iss 1, Pp 1-42 (2022)
Abstract: Abstract Background Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings an...
Gold nanoparticle-enhanced X-ray microtomography of the rodent reveals region-specific cerebrospinal fluid circulation in the brain
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract: Cerebrospinal fluid (CSF) is essential for brain development. Here, the authors use gold nanoparticle enhanced X-ray microtomography to map CSF distribution in post-natal rodents and describe particle size-dependent CSF pathways that transport CSF into...
Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort studyResearch in context
Publication Type: Academic Journal
Source(s): EClinicalMedicine, Vol 57, Iss , Pp 101896- (2023)
Abstract: Summary: Background: The scale of COVID-19 and its well documented long-term sequelae support a need to understand long-term outcomes including frailty. Methods: This prospective cohort study recruited adults who had survived hospitalisation with clini...
Separation of track- and shower-like energy deposits in ProtoDUNE-SP using a convolutional neural network
Publication Type: Academic Journal
Source(s): European Physical Journal C: Particles and Fields, Vol 82, Iss 10, Pp 1-19 (2022)
Abstract: Abstract Liquid argon time projection chamber detector technology provides high spatial and calorimetric resolutions on the charged particles traversing liquid argon. As a result, the technology has been used in a number of recent neutrino experiments,...
Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Abstract: The QT interval is a heritable electrocardiographic measure associated with arrhythmia risk when prolonged. Here, the authors used a series of genetic analyses to identify genetic loci, pathways, therapeutic targets, and relationships with cardiovascul...
Pharmacokinetics of hydroxychloroquine in paediatric lupus: data from a novel, direct-to-family clinical trial
Publication Type: Academic Journal
Source(s): Lupus Science and Medicine, Vol 9, Iss 1 (2022)
Abstract: Objective Determine the pharmacokinetics (PK) and exposure–response of hydroxychloroquine (HCQ) and desethylhydroxychloroquine (DHCQ) in paediatric SLE (pSLE).Methods We conducted an exploratory phase 2, direct-to-family trial. Children enrolled in the...
Density dependent regulation of inflammatory responses in macrophages
Publication Type: Academic Journal
Source(s): Frontiers in Immunology, Vol 13 (2022)
Abstract: Macrophage distribution density is tightly regulated within the body, yet the importance of macrophage crowding during in vitro culture is largely unstudied. Using a human induced pluripotent stem cell (iPSC)-derived macrophage model of tissue resident...