Abstract:An efficient continuous flow process for the macrolactonization of seco acids and diacids using diols in the presence of Mukaiyama reagent ( N -methyl-2-chloropyridinium iodide) has been developed for medium to large sized macrocyclic lactones. In comp...
Abstract:Herein, we have developed a new approach for the synthesis of 11 to 21-membered macrolactones via intramolecular dehydrogenative coupling of primary alcohols by using Ru-MACHO as a catalyst and Cs 2 CO 3 as a base. This protocol generated 11-21-ring-si...
Abstract:Herein we describe a new approach for end-to-end cyclization to construct macrocycles through the inter/intramolecular dehydrogenative coupling of alcohols and ketones in the presence of a Ru-MACHO catalyst. This method is highly atom economical and su...
Abstract:A base-free and acceptorless Ru-catalyzed dehydrogenative approach has been developed for the synthesis of N -heterocycles by using 1,3-dicarbonyls and amino alcohols through a domino sequential enamine formation and intramolecular oxidative cyclizatio...
Abstract:Cancer is the second largest leading cause of death worldwide and breast cancer is the most prevailing cause of mortality among all cases of malignant neoplastic disease in adult females. The incidence rate of breast malignant neoplastic disease is pre...