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 "Jamdade AB"
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Continuous Flow Inter- and Intramolecular Macrolactonization under High Dilution Conditions.

Publication Type: Academic Journal

Source(s): The Journal of organic chemistry [J Org Chem] 2023 Mar 17; Vol. 88 (6), pp. 3740-3759. Date of Electronic Publication: 2023 Mar 02.

Abstract: An efficient continuous flow process for the macrolactonization of seco acids and diacids using diols in the presence of Mukaiyama reagent ( N -methyl-2-chloropyridinium iodide) has been developed for medium to large sized macrocyclic lactones. In comp...

Dehydrogenative Intramolecular Macrolactonization of Dihydroxy Compounds Using Ru-MACHO Catalyst.

Publication Type: Academic Journal

Source(s): Organic letters [Org Lett] 2022 Jun 24; Vol. 24 (24), pp. 4394-4398. Date of Electronic Publication: 2022 Jun 14.

Abstract: Herein, we have developed a new approach for the synthesis of 11 to 21-membered macrolactones via intramolecular dehydrogenative coupling of primary alcohols by using Ru-MACHO as a catalyst and Cs 2 CO 3 as a base. This protocol generated 11-21-ring-si...

Ru-MACHO-Catalyzed Direct Inter/Intramolecular Macrocyclization of Alcohols and Ketones.

Publication Type: Academic Journal

Source(s): Organic letters [Org Lett] 2021 Oct 01; Vol. 23 (19), pp. 7386-7390. Date of Electronic Publication: 2021 Sep 10.

Abstract: Herein we describe a new approach for end-to-end cyclization to construct macrocycles through the inter/intramolecular dehydrogenative coupling of alcohols and ketones in the presence of a Ru-MACHO catalyst. This method is highly atom economical and su...

Catalytic Acceptorless Dehydrogenation of Amino Alcohols and 2-Hydroxybenzyl Alcohols for Annulation Reaction under Neutral Conditions.

Publication Type: Academic Journal

Source(s): The Journal of organic chemistry [J Org Chem] 2021 Jul 02; Vol. 86 (13), pp. 8805-8828. Date of Electronic Publication: 2021 Jun 21.

Abstract: A base-free and acceptorless Ru-catalyzed dehydrogenative approach has been developed for the synthesis of N -heterocycles by using 1,3-dicarbonyls and amino alcohols through a domino sequential enamine formation and intramolecular oxidative cyclizatio...

Curcumin as an adjuvant to breast cancer treatment.

Publication Type: Academic Journal

Source(s): Anti-cancer agents in medicinal chemistry [Anticancer Agents Med Chem] 2015; Vol. 15 (5), pp. 647-56.

Abstract: Cancer is the second largest leading cause of death worldwide and breast cancer is the most prevailing cause of mortality among all cases of malignant neoplastic disease in adult females. The incidence rate of breast malignant neoplastic disease is pre...

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