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Advanced Search Results For "Jason Laws"

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 "Jason Laws"
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Essentials of Financial Management

Essentials of Financial Management

Publication Type:eBook

Abstract:An Open Access edition of this book is available on the Liverpool University Press website (https://www.liverpooluniversitypress.co.uk/pages/essentials-of-financial-management-efm).Essentials of Financial Management is an Open Access e-textbook (paperb...

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Trends in Canadian prescription drug purchasing: 2001–2020

Publication Type:Academic Journal

Source(s):Journal of Pharmaceutical Policy and Practice, Vol 15, Iss 1, Pp 1-7 (2022)

Abstract:Abstract Background In 2019, more than $34.5 billion was spent on prescription drugs in Canada. However, little is known about the distribution of this spending across medications and settings (outpatient and inpatient) over time. The objective of this...

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Microengineered platforms for characterizing the contractile function of in vitro cardiac models

Publication Type:Academic Journal

Source(s):Microsystems & Nanoengineering, Vol 8, Iss 1, Pp 1-22 (2022)

Abstract:Abstract Emerging heart-on-a-chip platforms are promising approaches to establish cardiac cell/tissue models in vitro for research on cardiac physiology, disease modeling and drug cardiotoxicity as well as for therapeutic discovery. Challenges still ex...

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Resistance profiling of Aspergillus fumigatus to olorofim indicates absence of intrinsic resistance and unveils the molecular mechanisms of acquired olorofim resistance

Publication Type:Academic Journal

Source(s):Emerging Microbes and Infections, Vol 0, Iss 0, Pp 1-33 (2022)

Abstract:Olorofim (F901318) is a new antifungal currently under clinical development that shows both in vitro and in vivo activity against a number of filamentous fungi including Aspergillus fumigatus. In this study we screened A. fumigatus isolates for intrins...

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Risk of severe illness from COVID‐19 among Aboriginal and Torres Strait Islander adults: the construct of ‘vulnerable populations’ obscures the root causes of health inequities

Publication Type:Academic Journal

Source(s):Australian and New Zealand Journal of Public Health, Vol 45, Iss 6, Pp 658-663 (2021)

Abstract:Abstract Objective: To quantify the prevalence of known health‐related risk factors for severe COVID‐19 illness among Aboriginal and Torres Strait Islander adults, and their relationship with social determinants. Methods: Weighted cross‐sectional analy...

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Gene editing enables rapid engineering of complex antibiotic assembly lines

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)

Abstract:Engineering biosynthetic assembly lines is a powerful path to new natural products but is challenging with current methods. Here the authors use CRISPR-Cas9 to exchange subdomains within NRPS to alter substrate selectivity.

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The impact of viral mutations on recognition by SARS-CoV-2 specific T cells

Publication Type:Academic Journal

Source(s):iScience, Vol 24, Iss 11, Pp 103353- (2021)

Abstract:Summary: We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of reco...

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Kramers nodal line metals

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)

Abstract:Chiral crystals with spin-orbit coupling (SOC) termed Kramers Weyl semimetals possess Weyl points at time-reversal invariant momenta. Here, the authors propose a new class of topological materials with doubly degenerate lines connecting time-reversal i...

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Risk Factors for Critical Coronavirus Disease 2019 and Mortality in Hospitalized Young Adults: An Analysis of the Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study (VIRUS) Coronavirus Disease 2019 Registry

Publication Type:Academic Journal

Source(s):Critical Care Explorations, Vol 3, Iss 8, p e0514 (2021)

Abstract:IMPORTANCE:. Even with its proclivity for older age, coronavirus disease 2019 has been shown to affect all age groups. However, there remains a lack of research focused primarily on the young adult population. OBJECTIVES:. To describe the epidemiology ...

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Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7

Publication Type:Academic Journal

Source(s):Cell Reports, Vol 35, Iss 13, Pp 109292- (2021)

Abstract:Summary: We report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike ΔH69/V70 in multiple independent lineages, often occurring after acquisition of receptor binding motif replacements such as N439K and Y453F, known to increase binding...

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