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Advanced Search Results For "Jiang, George J."

1 - 10 of 2,262 results for
 "Jiang, George J."
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Predicting prognosis and IDH mutation status for patients with lower-grade gliomas using whole slide images

Publication Type:Academic Journal

Source(s):Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)

Abstract:Abstract We developed end-to-end deep learning models using whole slide images of adults diagnosed with diffusely infiltrating, World Health Organization (WHO) grade 2 gliomas to predict prognosis and the mutation status of a somatic biomarker, isocitr...

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Whole genome sequence analyses of eGFR in 23,732 people representing multiple ancestries in the NHLBI trans-omics for precision medicine (TOPMed) consortium

Publication Type:Academic Journal

Source(s):EBioMedicine, Vol 63, Iss , Pp 103157- (2021)

Abstract:Background: Genetic factors that influence kidney traits have been understudied for low frequency and ancestry-specific variants. Methods: We combined whole genome sequencing (WGS) data from 23,732 participants from 10 NHLBI Trans-Omics for Precision M...

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A validated mouse model capable of recapitulating the protective effects of female sex hormones on ascending aortic aneurysms and dissections (AADs)

Publication Type:Academic Journal

Source(s):Physiological Reports, Vol 8, Iss 22, Pp n/a-n/a (2020)

Abstract:Abstract Fewer females develop AADs (ascending aortic aneurysms and dissections) and the reasons for this protection remain poorly understood. The present study seeks to develop a mouse model that may be utilized to address this sexual dimorphism. Adul...

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Androgen Receptor Signaling Induces Cisplatin Resistance via Down-Regulating GULP1 Expression in Bladder Cancer

Publication Type:Academic Journal

Source(s):International Journal of Molecular Sciences, Vol 22, Iss 10030, p 10030 (2021)

Abstract:The underlying molecular mechanisms of resistance to cisplatin-based systemic chemotherapy in bladder cancer patients remain to be elucidated, while the link between androgen receptor (AR) activity and chemosensitivity in urothelial cancer has been imp...

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Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)

Abstract:GWAS have identified more than 500 genetic loci associated with blood lipid levels. Here, the authors report a genome-wide analysis of interactions between genetic markers and physical activity, and find that physical activity modifies the effects of f...

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Identification of BXDC2 as a Key Downstream Effector of the Androgen Receptor in Modulating Cisplatin Sensitivity in Bladder Cancer

Publication Type:Academic Journal

Source(s):Cancers, Vol 13, Iss 975, p 975 (2021)

Abstract:Underlying mechanisms for resistance to cisplatin-based chemotherapy in bladder cancer patients are largely unknown, although androgen receptor (AR) activity, as well as extracellular signal-regulated kinase (ERK) signaling, has been indicated to corre...

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ATF2 promotes urothelial cancer outgrowth via cooperation with androgen receptor signaling

Publication Type:Academic Journal

Source(s):Endocrine Connections, Vol 7, Iss 12, Pp 1397-1408 (2018)

Abstract:We investigated the functional role of ATF2, a transcription factor normally activated via its phosphorylation in response to phospho-ERK/MAPK signals, in the outgrowth of urothelial cancer. In both neoplastic and non-neoplastic urothelial cells, the e...

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Use of >100,000 NHLBI Trans-Omics for Precision Medicine (TOPMed) Consortium whole genome sequences improves imputation quality and detection of rare variant associations in admixed African and Hispanic/Latino populations.

Publication Type:Academic Journal

Source(s):PLoS Genetics, Vol 15, Iss 12, p e1008500 (2019)

Abstract:Most genome-wide association and fine-mapping studies to date have been conducted in individuals of European descent, and genetic studies of populations of Hispanic/Latino and African ancestry are limited. In addition, these populations have more compl...

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Information uncertainty of fiscal year end quarter earnings.

Publication Type:Academic Journal

Source(s):Review of Accounting & Finance; 2022, Vol. 21 Issue 2, p83-108, 26p

Abstract:Copyright of Review of Accounting & Finance is the property of Emerald Publishing Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users m...

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Why do investors discount earnings announced late?

Publication Type:Academic Journal

Source(s):Review of Quantitative Finance & Accounting; Apr2022, Vol. 58 Issue 3, p977-1014, 38p

Abstract:Copyright of Review of Quantitative Finance & Accounting is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users...

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