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Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide.
Publication Type: Academic Journal
Source(s): Proceedings of the National Academy of Sciences of the United States of America; 7/24/2018, Vol. 115 Issue 30, pE7119-E7128, 10p
Abstract: Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright ho...
A novel allosteric site employs a conserved inhibition mechanism in human kidney-type glutaminase.
Publication Type: Academic Journal
Source(s): The FEBS journal [FEBS J] 2023 May; Vol. 290 (9), pp. 2437-2448. Date of Electronic Publication: 2022 Nov 09.
Abstract: Glutaminase catalyses the metabolic process called glutaminolysis. Cancer cells harness glutaminolysis to increase energy reserves under stressful conditions for rapid proliferation. Glutaminases are upregulated in many tumours. In humans, the kidney-t...
Structural Understanding of Fungal Terpene Synthases for the Formation of Linear or Cyclic Terpene Products.
Publication Type: Academic Journal
Source(s): ACS catalysis [ACS Catal] 2023 Mar 27; Vol. 13 (7), pp. 4949-4959. Date of Electronic Publication: 2023 Mar 27 (Print Publication: 2023).
Abstract: Terpene synthases (TPSs), known gatekeepers of terpenoid diversity, are the main targets for enzyme engineering attempts. To this end, we have determined the crystal structure of Agrocybe pediades linalool synthase (Ap.LS), which has been recently repo...
Structures of apo Cas12a and its complex with crRNA and DNA reveal the dynamics of ternary complex formation and target DNA cleavage.
Publication Type: Academic Journal
Source(s): PLoS biology [PLoS Biol] 2023 Mar 14; Vol. 21 (3), pp. e3002023. Date of Electronic Publication: 2023 Mar 14 (Print Publication: 2023).
Abstract: Cas12a is a programmable nuclease for adaptive immunity against invading nucleic acids in CRISPR-Cas systems. Here, we report the crystal structures of apo Cas12a from Lachnospiraceae bacterium MA2020 (Lb2) and the Lb2Cas12a+crRNA complex, as well as t...
Bacterial antagonism of Chromobacterium haemolyticum and characterization of its putative type VI secretion system.
Publication Type: Academic Journal
Source(s): Research in microbiology [Res Microbiol] 2022 Mar-Apr; Vol. 173 (3), pp. 103918. Date of Electronic Publication: 2021 Dec 11.
Abstract: This study reports the isolation of a new Chromobacterium haemolyticum strain named WI5 from a hydroponic farming facility. WI5 exhibited remarkable bacterial antagonistic properties, eliminating Salmonella, Escherichia coli, Listeria monocytogenes and...
Crystal structure of Aedes aegypti trypsin inhibitor in complex with μ-plasmin reveals role for scaffold stability in Kazal-type serine protease inhibitor.
Publication Type: Academic Journal
Source(s): Protein science : a publication of the Protein Society [Protein Sci] 2022 Feb; Vol. 31 (2), pp. 470-484. Date of Electronic Publication: 2021 Nov 29.
Abstract: Kazal-type protease inhibitor specificity is believed to be determined by sequence of the reactive-site loop that make most, if not all, contacts with the serine protease. Here, we determined the complex crystal structure of Aedes aegypti trypsin inhib...
Structure of Aedes aegypti carboxypeptidase B1-inhibitor complex uncover the disparity between mosquito and non-mosquito insect carboxypeptidase inhibition mechanism.
Publication Type: Academic Journal
Source(s): Protein science : a publication of the Protein Society [Protein Sci] 2021 Dec; Vol. 30 (12), pp. 2445-2456. Date of Electronic Publication: 2021 Nov 05.
Abstract: Metallocarboxypeptidases (MCPs) in the mosquito midgut play crucial roles in infection, as well as in mosquito dietary digestion, reproduction, and development. MCPs are also part of the digestive system of plant-feeding insects, representing key targe...
Structural and mechanistic insight into stem-loop RNA processing by yeast Pichia stipitis Dicer.
Publication Type: Academic Journal
Source(s): Protein science : a publication of the Protein Society [Protein Sci] 2021 Jun; Vol. 30 (6), pp. 1210-1220. Date of Electronic Publication: 2021 Apr 28.
Abstract: Dicer is a member of the ribonuclease III enzyme family and processes double-stranded RNA into small functional RNAs. The variation in the domain architecture of Dicer among different species whilst preserving its biological dicing function is intrigui...
Structural basis for p50RhoGAP BCH domain-mediated regulation of Rho inactivation.
Publication Type: Academic Journal
Source(s): Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2021 May 25; Vol. 118 (21).
Abstract: Spatiotemporal regulation of signaling cascades is crucial for various biological pathways, under the control of a range of scaffolding proteins. The BNIP-2 and Cdc42GAP Homology (BCH) domain is a highly conserved module that targets small GTPases and ...
The Autocatalytic Cleavage Domain Is Not Required for the Activity of ScpC, a Virulence Protease from Streptococcus pyogenes : A Structural Insight.
Publication Type: Academic Journal
Source(s): Biochemistry [Biochemistry] 2021 May 18; Vol. 60 (19), pp. 1564-1568. Date of Electronic Publication: 2021 Apr 30.
Abstract: Group A Streptococcus (GAS, or Streptococcus pyogenes ) is a leading human bacterial pathogen with diverse clinical manifestations, ranging from mild to life-threatening and to severe immune sequela. These diseases, combined, account for more than half...