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Advanced Search Results For "KAUFMANN, ERIC"

1 - 10 of 528 results for
 "KAUFMANN, ERIC"
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Anxiety-like behavior and anxiolytic treatment in the Rett syndrome natural history study

Publication Type:Academic Journal

Source(s):Journal of Neurodevelopmental Disorders, Vol 14, Iss 1, Pp 1-11 (2022)

Abstract:Abstract Background Rett syndrome (RTT) is a neurodevelopmental disorder most often related to a pathogenic variant in the X-linked MECP2 gene. Internalizing behaviors appear to be common, but standard methods of diagnosing anxiety are not readily appl...

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The Corona Immunitas Digital Follow-Up eCohort to Monitor Impacts of the SARS-CoV-2 Pandemic in Switzerland: Study Protocol and First Results

Publication Type:Academic Journal

Source(s):International Journal of Public Health, Vol 67 (2022)

Abstract:Objectives: To describe the rationale, organization, and procedures of the Corona Immunitas Digital Follow-Up (CI-DFU) eCohort and to characterize participants at baseline.Methods: Participants of Corona Immunitas, a population-based nationwide SARS-Co...

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RAS mutations drive proliferative chronic myelomonocytic leukemia via a KMT2A-PLK1 axis

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 12, Iss 1, Pp 1-18 (2021)

Abstract:Chronic myelomonocytic leukaemia is classified as proliferative (pCMML) or dysplastic based on the white blood cell counts but biological differences are unclear. Here, the authors show genetic, transcriptomic and epigenomic differences between these t...

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Depletion of HIF-1α by Inducible Cre/loxP Increases the Sensitivity of Cultured Murine Hepatocytes to Ionizing Radiation in Hypoxia

Publication Type:Academic Journal

Source(s):Cells, Vol 11, Iss 1671, p 1671 (2022)

Abstract:The transcription factor hypoxia-inducible factor (HIF) is the main oxygen sensor which regulates adaptation to cellular hypoxia. The aim of this study was to establish cultured murine hepatocyte derived cells (mHDC) as an in vitro model and to analyze...

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Maternal outcomes and risk factors for COVID-19 severity among pregnant women

Publication Type:Academic Journal

Source(s):Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)

Abstract:Abstract Pregnant women may be at higher risk of severe complications associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), which may lead to obstetrical complications. We performed a case control study comparing pregnant wo...

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Integrating regional and local monitoring data and assessment tools to evaluate habitat conditions and inform river restoration

Publication Type:Academic Journal

Source(s):Ecological Indicators, Vol 131, Iss , Pp 108213- (2021)

Abstract:Restoring degraded rivers requires initial assessment of the fluvial landscape to identify stressors and riverine features that can be enhanced. We associated local-scale river habitat data collected using standardized national monitoring tools with mo...

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The Increasing Frequency of Terms Denoting Political Extremism in U.S. and U.K. News Media

Publication Type:Academic Journal

Source(s):Social Sciences, Vol 11, Iss 167, p 167 (2022)

Abstract:The term political extremism is commonly used to refer to political attitudes considered to be outside the ideological mainstream. This study leverages computational content analysis of big data to longitudinally examine (1970–2019) the prevalence of t...

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The genetic architecture of human brainstem structures and their involvement in common brain disorders

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

Abstract:The genetic architecture underlying brainstem regions and how this links to common brain disorders is not well understood. Here, the authors use MRI and GWAS data from 27,034 individuals to identify genetic and morphological brainstem features that inf...

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Dantrolene Attenuates Cardiotoxicity of Doxorubicin Without Reducing its Antitumor Efficacy in a Breast Cancer Model

Publication Type:Academic Journal

Source(s):Translational Oncology, Vol 13, Iss 2, Pp 471-480 (2020)

Abstract:Dysregulation of calcium homeostasis is a major mechanism of doxorubicin (DOX)-induced cardiotoxicity. Treatment with DOX causes activation of sarcoplasmic reticulum (SR) ryanodine receptor (RYR) and rapid release of Ca2+ in the cytoplasm resulting in ...

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The Influence of Pineapple Leaf Fiber Orientation and Volume Fraction on Methyl Methacrylate-Based Polymer Matrix for Prosthetic Socket Application

Publication Type:Academic Journal

Source(s):Polymers, Vol 13, Iss 3381, p 3381 (2021)

Abstract:This work reports on the use of low-cost pineapple leaf fiber (PALF) as an alternative reinforcing material to the established, commonly used material for prosthetic socket fabrication which is carbon-fiber-reinforced composite (CFRC) due to the high s...

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