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Forced Intercalation Peptide Nucleic Acid Probes for the Detection of an Adenosine-to-Inosine Modification.
Publication Type: Academic Journal
Source(s): ACS Omega; 1/10/2023, Vol. 8 Issue 1, p238-248, 11p
Targeting MYC activity in double-hit lymphoma with MYC and BCL2 and/or BCL6 rearrangements with epigenetic bromodomain inhibitors
Publication Type: Academic Journal
Source(s): Journal of Hematology & Oncology, Vol 12, Iss 1, Pp 1-13 (2019)
Abstract: Abstract Double/triple-hit lymphomas (DHL/THL) account for 5–10% of diffuse large B cell lymphoma (DLBCL) with rearrangement of MYC and BCL2 and/or BCL6 resulting in MYC overexpression. Despite the poor prognosis of DHL, R-CHOP chemotherapy remains the...
A missense variant in SLC39A8 is associated with severe idiopathic scoliosis
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 9, Iss 1, Pp 1-7 (2018)
Abstract: The majority of scoliosis is considered idiopathic with onset in adolescence (AIS) and has a genetic contribution. Here, the authors perform an exome wide association study of data from 457 severe AIS cases and 987 controls, and find a missense variant...
Early Release Science of the exoplanet WASP-39b with JWST NIRSpec G395H
Publication Type: Periodical
Source(s): Nature; 20230101, Issue: Preprints p1-6, 6p
Abstract: Measuring the abundances of carbon and oxygen in exoplanet atmospheres is considered a crucial avenue for unlocking the formation and evolution of exoplanetary systems1,2. Access to the chemical inventory of an exoplanet requires high-precision observa...
Early Release Science of the exoplanet WASP-39b with JWST NIRISS
Publication Type: Periodical
Source(s): Nature; 20230101, Issue: Preprints p1-6, 6p
Abstract: The Saturn-mass exoplanet WASP-39b has been the subject of extensive efforts to determine its atmospheric properties using transmission spectroscopy1–4. However, these efforts have been hampered by modelling degeneracies between composition and cloud p...
Early Release Science of the exoplanet WASP-39b with JWST NIRCam
Publication Type: Periodical
Source(s): Nature; 20230101, Issue: Preprints p1-6, 6p
Abstract: Measuring the metallicity and carbon-to-oxygen (C/O) ratio in exoplanet atmospheres is a fundamental step towards constraining the dominant chemical processes at work and, if in equilibrium, revealing planet formation histories. Transmission spectrosco...
Predominantly Persistent Intraretinal Fluid in the Comparison of Age-related Macular Degeneration Treatments Trials
Publication Type: Periodical
Source(s): Ophthalmology Retina; September 2022, Vol. 6 Issue: 9 p771-785, 15p
Abstract: To describe predominantly persistent intraretinal fluid (PP-IRF) and its association with visual acuity (VA) and retinal anatomic findings at long-term follow-up in eyes treated with pro re nata (PRN) ranibizumab or bevacizumab for neovascular age-rela...
Driver Fusions and Their Implications in the Development and Treatment of Human Cancers
Publication Type: Academic Journal
Source(s): Cell Reports, Vol 23, Iss 1, Pp 227-238.e3 (2018)
Abstract: Summary: Gene fusions represent an important class of somatic alterations in cancer. We systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling tools. We identified a total of 25,664 fusions, with a 63% ...
The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma
Publication Type: Academic Journal
Source(s): Cell Reports, Vol 23, Iss 1, Pp 313-326.e5 (2018)
Abstract: Summary: Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic sub...
Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images
Publication Type: Academic Journal
Source(s): Cell Reports, Vol 23, Iss 1, Pp 181-193.e7 (2018)
Abstract: Summary: Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumor-infiltrating lymphocytes (TILs) based on H&E images f...