Advanced Search Results For "Karchin, Rachel"

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Publication Type: Academic Journal

Source(s): Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)

Abstract: Abstract Immune checkpoint blockade (ICB) has demonstrated efficacy by reinvigorating immune cytotoxicity against tumors. However, the mechanisms underlying how ICB induces responses in a subset of patients remain unclear. Using bulk and single-cell tr...

Publication Type: Academic Journal

Source(s): Frontiers in Oncology, Vol 12 (2022)

Abstract: IntroductionThe magnitude of response to immune checkpoint inhibitor (ICI) therapy may be sex-dependent, as females have lower response rates and decreased survival after ICI monotherapy. The mechanisms underlying this sex dimorphism in ICI response ar...

Publication Type: Academic Journal

Source(s): Scientific Reports; 1/18/2023, Vol. 13 Issue 1, p1-12, 12p

Abstract: Copyright of Scientific Reports is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or ...

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)

Abstract: Neoplastic pancreatic cysts are associated with invasive pancreatic cancer, but their origins and evolutionary relationships are unclear. Here, the authors present the evolutionary analysis of neoplastic cysts and report them as precursors of invasive ...

Publication Type: Periodical

Source(s): Nature Medicine; 20230101, Issue: Preprints p1-10, 10p

Abstract: Tumor mutation burden is an imperfect proxy of tumor foreignness and has therefore failed to consistently demonstrate clinical utility in predicting responses in the context of immunotherapy. We evaluated mutations in regions of the genome that are unl...

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)

Abstract: In pancreatic cancer the Kras and Trp53 transgene driven KPC mouse model is used to experimentally study disease processes. Here, the authors analyse tumour evolution within the KPC model, finding both linear and branched evolution and highlighting the...

Publication Type: Academic Journal

Source(s): ACS Infectious Diseases; 12/9/2022, Vol. 8 Issue 12, p2451-2463, 13p

Publication Type: Academic Journal

Source(s): Frontiers in Oncology; 8/3/2022, Vol. 12, p1-12, 12p

Abstract: Copyright of Frontiers in Oncology is the property of Frontiers Media S.A. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, downl...

Publication Type: Academic Journal

Source(s): Bioinformatics; Aug2022, Vol. 38 Issue 15, p3677-3683, 7p

Abstract: Copyright of Bioinformatics is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, dow...

Publication Type: Academic Journal

Source(s): Genome Medicine, Vol 9, Iss 1, Pp 1-10 (2017)

Abstract: Abstract The translation of personal genomics to precision medicine depends on the accurate interpretation of the multitude of genetic variants observed for each individual. However, even when genetic variants are predicted to modify a protein, their f...