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Advanced Search Results For "Kelly, David L"

1 - 10 of 9,246 results for
 "Kelly, David L"
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Plasma virome and the risk of blood-borne infection in persons with substance use disorder

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)

Abstract:Spread of bloodborne infections, such as HCV and HIV, is a problem, particularly amongst people who inject drugs (PWID). Here, the authors describe and then confirm in observational PWID cohorts that those with more non-pathogenic viruses in plasma wer...

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Markets versus Mechanisms.

Publication Type:Academic Journal

Source(s):Review of Financial Studies; Jul2022, Vol. 35 Issue 7, p3139-3174, 36p

Abstract:Copyright of Review of Financial Studies is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users m...

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Malaria transmission-blocking conjugate vaccine in ALFQ adjuvant induces durable functional immune responses in rhesus macaques

Publication Type:Academic Journal

Source(s):npj Vaccines, Vol 6, Iss 1, Pp 1-10 (2021)

Abstract:Abstract Malaria transmission-blocking vaccines candidates based on Pfs25 and Pfs230 have advanced to clinical studies. Exoprotein A (EPA) conjugate of Pfs25 in Alhydrogel® developed functional immunity in humans, with limited durability. Pfs230 conjug...

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Carbohydrates from Pseudomonas aeruginosa biofilms interact with immune C-type lectins and interfere with their receptor function

Publication Type:Academic Journal

Source(s):npj Biofilms and Microbiomes, Vol 7, Iss 1, Pp 1-14 (2021)

Abstract:Abstract Bacterial biofilms represent a challenge to the healthcare system because of their resilience against antimicrobials and immune attack. Biofilms consist of bacterial aggregates embedded in an extracellular polymeric substance (EPS) composed of...

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The impact of viral mutations on recognition by SARS-CoV-2 specific T cells

Publication Type:Academic Journal

Source(s):iScience, Vol 24, Iss 11, Pp 103353- (2021)

Abstract:Summary: We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of reco...

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A Novel Germline Heterozygous BCL11B Variant Causing Severe Atopic Disease and Immune Dysregulation

Publication Type:Academic Journal

Source(s):Frontiers in Immunology, Vol 12 (2021)

Abstract:B-cell lymphoma/leukemia 11B (BCL11B) is a C2H2 zinc finger transcription factor that is critically important for regulating the development and function of a variety of systems including the central nervous system, the skin, and the immune system. Ger...

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Evolution of immune responses to SARS-CoV-2 in mild-moderate COVID-19

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)

Abstract:Longitudinal analyses are needed to show how the immune response to Sars-Cov-2 infection changes over time. Here, the authors use multiple strategies to profile the change in immune cell responses from patients with convalescent COVID-19 over the cours...

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Implementing stakeholder engagement to explore alternative models of consent: An example from the PREP-IT trials

Publication Type:Academic Journal

Source(s):Contemporary Clinical Trials Communications, Vol 22, Iss , Pp 100787- (2021)

Abstract:Introduction: Cluster randomized crossover trials are often faced with a dilemma when selecting an optimal model of consent, as the traditional model of obtaining informed consent from participant's before initiating any trial related activities may no...

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Double blind randomized controlled trial of deep brain stimulation for obsessive-compulsive disorder: Clinical trial design

Publication Type:Academic Journal

Source(s):Contemporary Clinical Trials Communications, Vol 22, Iss , Pp 100785- (2021)

Abstract:Obsessive-compulsive disorder (OCD), a leading cause of disability, affects ~1–2% of the population, and can be distressing and disabling. About 1/3 of individuals demonstrate poor responsiveness to conventional treatments. A small proportion of these ...

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Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7

Publication Type:Academic Journal

Source(s):Cell Reports, Vol 35, Iss 13, Pp 109292- (2021)

Abstract:Summary: We report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike ΔH69/V70 in multiple independent lineages, often occurring after acquisition of receptor binding motif replacements such as N439K and Y453F, known to increase binding...

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