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ICON-Sapphire: simulating the components of the Earth system and their interactions at kilometer and subkilometer scales
Publication Type: Academic Journal
Source(s): Geoscientific Model Development, Vol 16, Pp 779-811 (2023)
Abstract: State-of-the-art Earth system models typically employ grid spacings of O(100 km), which is too coarse to explicitly resolve main drivers of the flow of energy and matter across the Earth system. In this paper, we present the new ICON-Sapphire model con...
Improved β-cell function leads to improved glucose tolerance in a transgenic mouse expressing lipoprotein lipase in adipocytes
Publication Type: Academic Journal
Source(s): Scientific Reports, Vol 12, Iss 1, Pp 1-17 (2022)
Abstract: Abstract Lipoprotein lipase (LPL) hydrolyzes the triglyceride core of lipoproteins and also functions as a bridge, allowing for lipoprotein and cholesterol uptake. Transgenic mice expressing LPL in adipose tissue under the control of the adiponectin pr...
Improving pediatric COVID-19 vaccine uptake using an mHealth tool (MoVeUp): study protocol for a randomized, controlled trial
Publication Type: Academic Journal
Source(s): Trials, Vol 23, Iss 1, Pp 1-33 (2022)
Abstract: Abstract Background Coronavirus disease 2019 (COVID-19) vaccines demonstrate excellent effectiveness against infection, severe disease, and death. However, pediatric COVID-19 vaccination rates lag among individuals from rural and other medically unders...
A randomized controlled trial of simulation training in teaching coronary angiographic views
Publication Type: Academic Journal
Source(s): BMC Medical Education, Vol 22, Iss 1, Pp 1-8 (2022)
Abstract: Abstract Introduction Simulation technology has an established role in teaching technical skills to cardiology fellows, but its impact on teaching trainees to interpret coronary angiographic (CA) images has not been systematically studied. The aim of t...
Author Correction: Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 14, Iss 1, Pp 1-2 (2023)
Bilirubin Levels Are Negatively Correlated with Adiposity in Obese Men and Women, and Its Catabolized Product, Urobilin, Is Positively Associated with Insulin Resistance
Publication Type: Academic Journal
Source(s): Antioxidants, Vol 12, Iss 170, p 170 (2023)
Abstract: Bilirubin levels in obese humans and rodents have been shown to be lower than in their lean counterparts. Some studies have proposed that the glucuronyl UGT1A1 enzyme that clears bilirubin from the blood increases in the liver with obesity. UGT1A1 clea...
Tau deposition patterns are associated with functional connectivity in primary tauopathies
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Abstract: Tau pathology drives neuronal dysfunction in 4- repeat tauopathies. Here, the authors combine tau-PET, resting-state fMRI and histopathology data, to show that brain connectivity is associated with tau deposition patterns in 4-repeat tauopathies.
The effect of sex on social cognition and functioning in schizophrenia
Publication Type: Academic Journal
Source(s): npj Schizophrenia, Vol 7, Iss 1, Pp 1-8 (2021)
Abstract: Abstract Social cognitive impairment is a core feature of schizophrenia and plays a critical role in poor community functioning in the disorder. However, our understanding of the relationship between key biological variables and social cognitive impair...
Room temperature XFEL crystallography reveals asymmetry in the vicinity of the two phylloquinones in photosystem I
Publication Type: Academic Journal
Source(s): Scientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
Abstract: Abstract Photosystem I (PS I) has a symmetric structure with two highly similar branches of pigments at the center that are involved in electron transfer, but shows very different efficiency along the two branches. We have determined the structure of c...
Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Abstract: Known genetic loci account for only a fraction of the genetic contribution to Alzheimer’s disease. Here, the authors have performed a large genome-wide meta-analysis comprising 409,435 individuals to discover 6 new loci and demonstrate the efficacy of ...