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Advanced Search Results For "Klionsky, Daniel J"

1 - 10 of 1,570 results for
 "Klionsky, Daniel J"
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SETD2 transcriptional control of ATG14L/S isoforms regulates autophagosome–lysosome fusion

Publication Type: Academic Journal

Source(s): Cell Death and Disease, Vol 13, Iss 11, Pp 1-13 (2022)

Abstract: Abstract Macroautophagy/autophagy is an evolutionarily conserved and tightly regulated catabolic process involved in the maintenance of cellular homeostasis whose dysregulation is implicated in several pathological processes. Autophagy begins with the ...

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Vps13 is Required for Efficient Autophagy in

Publication Type: Academic Journal

Source(s): Contact, Vol 5 (2022)

Abstract: Vps13 is a large, conserved protein that transports lipids between membranes. Its localization at multiple organelle membranes and membrane contact sites suggests its important physiological roles. In addition, the high correlation of mutant VPS13 with...

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Induction of autophagy-dependent ferroptosis to eliminate drug-tolerant human retinoblastoma cells

Publication Type: Academic Journal

Source(s): Cell Death and Disease, Vol 13, Iss 6, Pp 1-11 (2022)

Abstract: Abstract Carboplatin is the most used first-line drug for the treatment of human retinoblastoma (RB), a rare form of cancer in infancy and childhood. However, the clinical application of carboplatin is restricted due to the emergence of acquired multi-...

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Autophagy regulation by RNA alternative splicing and implications in human diseases

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)

Abstract: Both alternative splicing and autophagy are core cell biological processes, but where they intersect has received little attention. Here, the authors reflect on recent connections identified between these pathways and consider their impact on human dis...

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Targeting autophagy in prostate cancer: preclinical and clinical evidence for therapeutic response

Publication Type: Academic Journal

Source(s): Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-37 (2022)

Abstract: Highlights • Prostate cancer is among the leading causes of death in men where targeting autophagy is of importance in treatment; • Autophagy governs proliferation and metastasis capacity of prostate cancer cells; • Autophagy modulation is of interest ...

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Life and Death Decisions—The Many Faces of Autophagy in Cell Survival and Cell Death

Publication Type: Academic Journal

Source(s): Biomolecules, Vol 12, Iss 866, p 866 (2022)

Abstract: Autophagy is a process conserved from yeast to humans. Since the discovery of autophagy, its physiological role in cell survival and cell death has been intensively investigated. The inherent ability of the autophagy machinery to sequester, deliver, an...

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Deciphering the role of autophagy in heart failure

Publication Type: Academic Journal

Source(s): Cardiology Plus, Vol 6, Iss 2, Pp 92-101 (2021)

Abstract: Heart failure (HF) refers to a progressive pathological condition when cardiac muscles fail to pump adequate blood supply (cardiac output) to meet the metabolic demand of the body. Among various cellular and molecular mechanisms identified for the onse...

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Autophagopathies: from autophagy gene polymorphisms to precision medicine for human diseases.

Publication Type: Academic Journal

Source(s): Autophagy; Nov2022, Vol. 18 Issue 11, p2519-2536, 18p

Abstract: Copyright of Autophagy is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or emai...

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Autophagy and SARS-CoV-2 infection: A possible smart targeting of the autophagy pathway

Publication Type: Academic Journal

Source(s): Virulence, Vol 11, Iss 1, Pp 805-810 (2020)

Abstract: The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) outbreak resulted in 5,993,317 confirmed cases worldwide with 365,394 confirmed deaths (as of May 29th, 2020, WHO). The molecular mechanism of virus infection and spread in the body is no...

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How Cells Deal with the Fluctuating Environment: Autophagy Regulation under Stress in Yeast and Mammalian Systems

Publication Type: Academic Journal

Source(s): Antioxidants, Vol 11, Iss 304, p 304 (2022)

Abstract: Eukaryotic cells frequently experience fluctuations of the external and internal environments, such as changes in nutrient, energy and oxygen sources, and protein folding status, which, after reaching a particular threshold, become a type of stress. Ce...

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