Advanced Search Results For "Knox, Thomas W."
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Characterisation of SARS-CoV-2 genomic variation in response to molnupiravir treatment in the AGILE Phase IIa clinical trial
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)
Abstract: Molnupiravir is an antiviral that forces lethal error catastrophe in SARS-CoV-2 RNAs. Here, the authors confirm the mechanism of action of molnupiravir in humans using samples obtained from the UK’s AGILE phase IIa clinical trial investigating the anti...
Substantial hysteresis in emergent temperature sensitivity of global wetland CH4 emissions
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
Abstract: Wetland methane emissions contribute to global warming, and are oversimplified in climate models. Here the authors use eddy covariance measurements from 48 global sites to demonstrate seasonal hysteresis in methane-temperature relationships and suggest...
The Community Land Model Version 5: Description of New Features, Benchmarking, and Impact of Forcing Uncertainty
Publication Type: Academic Journal
Source(s): Journal of Advances in Modeling Earth Systems, Vol 11, Iss 12, Pp 4245-4287 (2019)
Abstract: Abstract The Community Land Model (CLM) is the land component of the Community Earth System Model (CESM) and is used in several global and regional modeling systems. In this paper, we introduce model developments included in CLM version 5 (CLM5), which...
26th Annual Computational Neuroscience Meeting (CNS*2017): Part 3
Publication Type: Academic Journal
Source(s): BMC Neuroscience, Vol 18, Iss S1, Pp 1-82 (2017)
Maternal and neonatal outcomes after caesarean delivery in the African Surgical Outcomes Study: a 7-day prospective observational cohort study
Publication Type: Academic Journal
Source(s): The Lancet Global Health, Vol 7, Iss 4, Pp e513-e522 (2019)
Abstract: Summary: Background: Maternal and neonatal mortality is high in Africa, but few large, prospective studies have been done to investigate the risk factors associated with these poor maternal and neonatal outcomes. Methods: A 7-day, international, prospe...
High-fidelity detection and sorting of nanoscale vesicles in viral disease and cancer
Publication Type: Academic Journal
Source(s): Journal of Extracellular Vesicles, Vol 8, Iss 1 (2019)
Abstract: Biological nanoparticles, including viruses and extracellular vesicles (EVs), are of interest to many fields of medicine as biomarkers and mediators of or treatments for disease. However, exosomes and small viruses fall below the detection limits of co...
ESICM LIVES 2016: part one
Publication Type: Academic Journal
Source(s): Intensive Care Medicine Experimental, Vol 4, Iss S1, Pp 1-203 (2016)
Qualitative investigation of the reasons behind opposition to water fluoridation in regional NSW, Australia
Publication Type: Academic Journal
Source(s): Public Health Research & Practice, Vol 27, Iss 1 (2017)
Abstract: Objectives: To investigate reasons behind strong opposition to water fluoridation in regional New South Wales, Australia, and to make recommendations to improve community engagement. Importance: Few studies have used qualitative methodologies to und...
Protecting important sites for biodiversity contributes to meeting global conservation targets.
Publication Type: Academic Journal
Source(s): PLoS ONE, Vol 7, Iss 3, p e32529 (2012)
Abstract: Protected areas (PAs) are a cornerstone of conservation efforts and now cover nearly 13% of the world's land surface, with the world's governments committed to expand this to 17%. However, as biodiversity continues to decline, the effectiveness of PAs ...
Evaluation of Evidence for Pathogenicity Demonstrates That BLK, KLF11, and PAX4 Should Not Be Included in Diagnostic Testing for MODY.
Publication Type: Academic Journal
Source(s): Diabetes. 2022, Vol. 71 Issue 5, p1128-1136. 9p.
Abstract: Maturity-onset diabetes of the young (MODY) is an autosomal dominant form of monogenic diabetes, reported to be caused by variants in 16 genes. Concern has been raised about whether variants in BLK (MODY11), KLF11 (MODY7), and PAX4 (MODY9) cause MODY. ...