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The Lipophilic Purine Nucleoside-Tdp1 Inhibitor-Enhances DNA Damage Induced by Topotecan In Vitro and Potentiates the Antitumor Effect of Topotecan In Vivo.
Publication Type: Academic Journal
Source(s): Molecules (Basel, Switzerland) [Molecules] 2022 Dec 31; Vol. 28 (1). Date of Electronic Publication: 2022 Dec 31.
Abstract: The use of cancer chemotherapy sensitizers is a promising approach to induce the effect of clinically used anticancer treatments. One of the interesting targets is Tyrosyl-DNA Phosphodiesterase 1 (Tdp1), a DNA-repair enzyme, that may prevent the action...
Antisense oligonucleotide gapmers containing phosphoryl guanidine groups reverse MDR1-mediated multiple drug resistance of tumor cells.
Publication Type: Academic Journal
Source(s): Molecular therapy. Nucleic acids [Mol Ther Nucleic Acids] 2021 Nov 29; Vol. 27, pp. 211-226. Date of Electronic Publication: 2021 Nov 29 (Print Publication: 2022).
Abstract: Antisense gapmer oligonucleotides containing phosphoryl guanidine (PG) groups, e.g., 1,3-dimethylimidazolidin-2-imine, at three to five internucleotidic positions adjacent to the 3' and 5' ends were prepared via the Staudinger chemistry, which is compa...
An Influence of Modification with Phosphoryl Guanidine Combined with a 2'-O-Methyl or 2'-Fluoro Group on the Small-Interfering-RNA Effect.
Publication Type: Academic Journal
Source(s): International journal of molecular sciences [Int J Mol Sci] 2021 Sep 10; Vol. 22 (18). Date of Electronic Publication: 2021 Sep 10.
Abstract: Small interfering RNA (siRNA) is the most important tool for the manipulation of mRNA expression and needs protection from intracellular nucleases when delivered into the cell. In this work, we examined the effects of siRNA modification with the phosph...
Amphiphilic "Like-a-Brush" Oligonucleotide Conjugates with Three Dodecyl Chains: Self-Assembly Features of Novel Scaffold Compounds for Nucleic Acids Delivery.
Publication Type: Academic Journal
Source(s): Nanomaterials (Basel, Switzerland) [Nanomaterials (Basel)] 2020 Sep 29; Vol. 10 (10). Date of Electronic Publication: 2020 Sep 29.
Abstract: The conjugation of lipophilic groups to oligonucleotides is a promising approach for improving nucleic acid-based therapeutics' intracellular delivery. Lipid oligonucleotide conjugates can self-aggregate in aqueous solution, which gains much attention ...
Transport Oligonucleotides-A Novel System for Intracellular Delivery of Antisense Therapeutics.
Publication Type: Academic Journal
Source(s): Molecules (Basel, Switzerland) [Molecules] 2020 Aug 11; Vol. 25 (16). Date of Electronic Publication: 2020 Aug 11.
Abstract: Biological activity of antisense oligonucleotides (asON), especially those with a neutral backbone, is often attenuated by poor cellular accumulation. In the present proof-of-concept study, we propose a novel delivery system for asONs which implies the...
Data on multimerization efficiency for short linear DNA templates and phosphoryl guanidine primers during isothermal amplification with Bst exo- DNA polymerase.
Publication Type: Academic Journal
Source(s): Data in brief [Data Brief] 2020 Jan 25; Vol. 29, pp. 105188. Date of Electronic Publication: 2020 Jan 25 (Print Publication: 2020).
Abstract: This article reports experimental data related to the research article entitled "Prevention of DNA multimerization using phosphoryl guanidine primers during isothermal amplification with Bst exo- DNA polymerase" (R.R. Garafutdinov, A.R. Sakhabutdinova,...
Prevention of DNA multimerization using phosphoryl guanidine primers during isothermal amplification with Bst exo- DNA polymerase.
Publication Type: Academic Journal
Source(s): Biochimie [Biochimie] 2020 Jan; Vol. 168, pp. 259-267. Date of Electronic Publication: 2019 Nov 22.
Abstract: Over the last two decades, isothermal amplification of nucleic acids has gained more attention due to a number of advantages over the widely used polymerase chain reaction. For isothermal amplification, DNA polymerases with strand-displacement activity...
Data for isolation and properties analysis of diastereomers of a mono-substituted phosphoryl guanidine trideoxyribonucleotide.
Publication Type: Academic Journal
Source(s): Data in brief [Data Brief] 2019 Jun 20; Vol. 25, pp. 104148. Date of Electronic Publication: 2019 Jun 20 (Print Publication: 2019).
Abstract: This article presents new data on the properties of the diastereomers of a mono-substituted phosphoryl guanidine trideoxyribonucleotides d(TpCp*A) [1,2]. The data include information on isolation, identification, treatment with snake venom phosphodiest...
Diastereomers of a mono-substituted phosphoryl guanidine trideoxyribonucleotide: Isolation and properties.
Publication Type: Academic Journal
Source(s): Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2019 Jun 11; Vol. 513 (4), pp. 807-811. Date of Electronic Publication: 2019 Apr 15.
Abstract: Recently, a new type of nucleic acid analogues with modified phosphate group, namely, phosphoryl guanidine oligonucleotides, has been described. In the present work, we assess the difference between diastereomers of a mono-substituted phosphoryl guanid...
Oxidative damage to epigenetically methylated sites affects DNA stability, dynamics and enzymatic demethylation.
Publication Type: Academic Journal
Source(s): Nucleic acids research [Nucleic Acids Res] 2018 Nov 16; Vol. 46 (20), pp. 10827-10839.
Abstract: DNA damage can affect various regulatory elements of the genome, with the consequences for DNA structure, dynamics, and interaction with proteins remaining largely unexplored. We used solution NMR spectroscopy, restrained and free molecular dynamics to...