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Advanced Search Results For "Landers, Eric"

1 - 10 of 192 results for
 "Landers, Eric"
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Crohn’s disease in endoscopic remission, obesity, and cases of high genetic risk demonstrates overlapping shifts in the colonic mucosal-luminal interface microbiome

Publication Type: Academic Journal

Source(s): Genome Medicine, Vol 14, Iss 1, Pp 1-20 (2022)

Abstract: Abstract Background Crohn’s disease (CD) patients demonstrate distinct intestinal microbial compositions and metabolic characteristics compared to unaffected controls. However, the impact of inflammation and underlying genetic risk on these microbial p...

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Neurocognitive trajectory and proteomic signature of inherited risk for Alzheimer's disease.

Publication Type: Academic Journal

Source(s): PLoS Genetics, Vol 18, Iss 9, p e1010294 (2022)

Abstract: For Alzheimer's disease-a leading cause of dementia and global morbidity-improved identification of presymptomatic high-risk individuals and identification of new circulating biomarkers are key public health needs. Here, we tested the hypothesis that a...

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ALS-associated KIF5A mutations abolish autoinhibition resulting in a toxic gain of function

Publication Type: Academic Journal

Source(s): Cell Reports, Vol 39, Iss 1, Pp 110598- (2022)

Abstract: Summary: Understanding the pathogenic mechanisms of disease mutations is critical to advancing treatments. ALS-associated mutations in the gene encoding the microtubule motor KIF5A result in skipping of exon 27 (KIF5AΔExon27) and the encoding of a prot...

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Loss of function mutations in GEMIN5 cause a neurodevelopmental disorder

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Abstract: GEMIN5, an RNA-binding protein, is required for formation of small nuclear ribonucleoproteins. Here, the authors identify loss of function mutations in GEMIN5 that are associated with a human neurodevelopmental disorder.

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High-Resolution Spatiotemporal Dynamics of Harmful Algae in the Indian River Lagoon (Florida)—A Case Study of Aureoumbra lagunensis, Pyrodinium bahamense, and Pseudo-nitzschia

Publication Type: Academic Journal

Source(s): Frontiers in Marine Science, Vol 8 (2021)

Abstract: The Indian River Lagoon (IRL), located on the east coast of Florida, is a complex estuarine ecosystem that is negatively affected by recurring harmful algal blooms (HABs) from distinct taxonomic/functional groups. Enhanced monitoring was established to...

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Polygenic background modifies penetrance of monogenic variants for tier 1 genomic conditions

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 11, Iss 1, Pp 1-9 (2020)

Abstract: Genetic variation predisposes to disease via monogenic and polygenic risk variants. Here, the authors assess the interplay between these types of variation on disease penetrance in 80,928 individuals. In carriers of monogenic variants, they show that d...

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Next Steps for Conservation Agriculture

Publication Type: Academic Journal

Source(s): Agronomy, Vol 11, Iss 2496, p 2496 (2021)

Abstract: The origins, history, and recent advances in Conservation Agriculture (CA) are reported. CA is now practiced worldwide on some 200 million hectares, important for mitigating climate change and ensuring food security. Its bedrock is Zero Tillage (ZT) wi...

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Prioritizing disease and trait causal variants at the TNFAIP3 locus using functional and genomic features

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

Abstract: While genome-wide association studies have yielded thousands of trait-associated loci, identifying causal variants remains challenging. Here, the authors perform seven genomics assays in various cell types to prioritize genetic variants in the TNFAIP3 ...

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An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 10, Iss 1, Pp 1-19 (2019)

Abstract: Most reagents designed to deliver cargo into cells are cationic and so cannot deliver cationic cargo. Here the authors show that pretreating cells with the anionic polymer poly(propylacrylic acid) facilitates the uptake and endosomal escape of a wide v...

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Modulation of actin polymerization affects nucleocytoplasmic transport in multiple forms of amyotrophic lateral sclerosis

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)

Abstract: Although defects in nucleocytoplasmic transport (NCT) may be central to the pathogenesis of ALS, the molecular mechanisms modulating the nuclear pore function are still largely unknown. Here, authors show that genetic and pharmacological modulation of ...

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