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Activation of the Hedgehog signaling pathway leads to fibrosis in aortic valves
Publication Type: Academic Journal
Source(s): Cell & Bioscience, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract: Abstract Background Fibrosis is a pathological wound healing process characterized by excessive extracellular matrix deposition, which interferes with normal organ function and contributes to ~ 45% of human mortality. Fibrosis develops in response to c...
Drivers of global mangrove loss and gain in social-ecological systems
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Abstract: Mangrove forests protect communities from storms and support fisheries. Here, the authors show that the association with economic growth has shifted from negatively impacting mangroves to enabling mangrove expansion, and that community forestry is prom...
Learning to Crawl: Determining the Role of Genetic Abnormalities on Postoperative Outcomes in Congenital Heart Disease
Publication Type: Academic Journal
Source(s): Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 11, Iss 19 (2022)
Abstract: Background Our cardiac center established a systematic approach for inpatient cardiovascular genetics evaluations of infants with congenital heart disease, including routine chromosomal microarray (CMA) testing. This provides a new opportunity to inves...
Microbial Diversity and Interaction Specificity in Kombucha Tea Fermentations
Publication Type: Academic Journal
Source(s): mSystems, Vol 7, Iss 3 (2022)
Abstract: ABSTRACT Despite the popularity of kombucha tea, the distribution of different microbes across kombucha ferments and how those microbes interact within communities are not well characterized. Using metagenomics, comparative genomics, synthetic communit...
Isolated Coarctation of the Aorta: Current Concepts and Perspectives
Publication Type: Academic Journal
Source(s): Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Abstract: Current management of isolated CoA, localized narrowing of the aortic arch in the absence of other congenital heart disease, is a success story with improved prenatal diagnosis, high survival and improved understanding of long-term complication. Isolat...
A Novel Human Biospecimen Repository for Clinical and Molecular Investigation of Thoracic Aortopathy
Publication Type: Academic Journal
Source(s): Cardiogenetics, Vol 11, Iss 17, Pp 148-163 (2021)
Abstract: Thoracic aortic aneurysm (TAA) is a heritable aortopathy with significant morbidity and mortality, affecting children and adults. Genetic causes, pathobiological mechanisms, and prognostic markers are incompletely understood. In 2015, the Collaborative...
Identification of a common polymorphism in COQ8B acting as a modifier of thoracic aortic aneurysm severity
Publication Type: Academic Journal
Source(s): HGG Advances, Vol 3, Iss 1, Pp 100057- (2022)
Abstract: Summary: Thoracic aortic aneurysm (TAA) predisposes to sudden, life-threatening aortic dissection. The factors that regulate interindividual variability in TAA severity are not well understood. Identifying a molecular basis for this variability has the...
Rapid detection of hepatitis C virus using recombinase polymerase amplification.
Publication Type: Academic Journal
Source(s): PLoS ONE, Vol 17, Iss 10, p e0276582 (2022)
Abstract: Over 71 million people are infected with hepatitis C virus (HCV) worldwide, and approximately 400,000 global deaths result from complications of untreated chronic HCV. Pan-genomic direct-acting antivirals (DAAs) have recently become widely available an...
A novel digital approach to describe real world outcomes among patients with constipation
Publication Type: Academic Journal
Source(s): npj Digital Medicine, Vol 4, Iss 1, Pp 1-9 (2021)
Abstract: Abstract Understanding day-to-day variations in symptoms and medication management can be important in describing patient centered outcomes for people with constipation. Patient Generated Health Data (PGHD) from digital devices is a potential solution,...
Activation of the Hedgehog signaling pathway leads to fibrosis in aortic valves.
Publication Type: Academic Journal
Source(s): Cell & Bioscience; 3/2/2023, Vol. 13 Issue 1, p1-9, 9p
Abstract: Copyright of Cell & Bioscience is the property of BioMed Central and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or em...