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Advanced Search Results For "Lau, Dominic"

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 "Lau, Dominic"
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Automated measurement of inter-arytenoid distance on 4D laryngeal CT: A validation study

Publication Type: Academic Journal

Source(s): PLoS ONE, Vol 18, Iss 1 (2023)

Abstract: Changes to the voice are prevalent and occur early in Parkinson’s disease. Correlates of these voice changes on four-dimensional laryngeal computed-tomography imaging, such as the inter-arytenoid distance, are promising biomarkers of the disease’s pres...


Inducible localized delivery of an anti-PD-1 scFv enhances anti-tumor activity of ROR1 CAR-T cells in TNBC

Publication Type: Academic Journal

Source(s): Breast Cancer Research, Vol 24, Iss 1, Pp 1-10 (2022)

Abstract: Abstract Background Chimeric antigen receptor (CAR)-T cells can induce powerful immune responses in patients with hematological malignancies but have had limited success against solid tumors. This is in part due to the immunosuppressive tumor microenvi...

Twelve-month observational study of children with cancer in 41 countries during the COVID-19 pandemic

Publication Type: Academic Journal

Source(s): BMJ Global Health, Vol 7, Iss 10 (2022)

Abstract: Introduction Childhood cancer is a leading cause of death. It is unclear whether the COVID-19 pandemic has impacted childhood cancer mortality. In this study, we aimed to establish all-cause mortality rates for childhood cancers during the COVID-19 pan...

Selectivity of Lewy body protein interactions along the aggregation pathway of α-synuclein

Publication Type: Academic Journal

Source(s): Communications Biology, Vol 4, Iss 1, Pp 1-16 (2021)

Abstract: To better understand the specific cascade of protein interactions that lead to the pathological aggregation of α-synuclein (wild-type and mutant forms), Leitão et al. present a method to measure interactions of monomeric, oligomeric, and fibrillar form...

Radiological correlates of vocal fold bowing as markers of Parkinson’s disease progression: A cross-sectional study utilizing dynamic laryngeal CT

Publication Type: Academic Journal

Source(s): PLoS ONE, Vol 16, Iss 10 (2021)

Abstract: Objective To determine whether arytenoid cartilage position and dynamics change with advancing duration and severity (as graded by MDS-UPDRS part III scores) in Parkinson’s disease, in a cross-sectional study design, we performed laryngeal four-dimensi...


Surgical site infection after gastrointestinal surgery in children: an international, multicentre, prospective cohort study

Publication Type: Academic Journal

Source(s): BMJ Global Health, Vol 5, Iss 12 (2020)

Abstract: Introduction Surgical site infection (SSI) is one of the most common healthcare-associated infections (HAIs). However, there is a lack of data available about SSI in children worldwide, especially from low-income and middle-income countries. This study...

A brief early intervention for adolescent depression that targets emotional mental images and memories: protocol for a feasibility randomised controlled trial (IMAGINE trial)

Publication Type: Academic Journal

Source(s): Pilot and Feasibility Studies, Vol 4, Iss 1, Pp 1-13 (2018)

Abstract: Abstract Background Adolescent depression is common and impairing. There is an urgent need to develop early interventions to prevent depression becoming entrenched. However, current psychological interventions are difficult to access and show limited e...

Integrated omics dissection of proteome dynamics during cardiac remodeling

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)

Abstract: Transcriptome data provide only a partial picture of disease states. Here, via integration of transcript-, protein abundance and protein turnover data for a mouse model of cardiac hypertrophy, the authors uncover additional disease gene signatures, and...


Pediatric Crohn's disease presenting with a large calcified pelvic mass

Publication Type: Academic Journal

Source(s): Journal of Pediatric Surgery Case Reports, Vol 22, Iss C, Pp 14-17 (2017)

Abstract: Small bowel Crohn's disease classically presents with symptoms of abdominal pain, diarrhea, and weight loss in the pediatric population. However, there is no published literature on its presentation associated with a dystrophically calcified pelvic mas...