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Advanced Search Results For "Leonard, Sarah"

1 - 10 of 2,584 results for
 "Leonard, Sarah"
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Rampant proteolysis at the intersection of therapy-induced hypoalbuminemia and acute pancreatitis

Publication Type: Academic Journal

Source(s): 4 open, Vol 5, p 14 (2022)

Abstract: Protease inhibition is the intended mechanism of action for drugs across a broad range of diseases: cancer, cardiovascular and stroke, diabetes mellitus, macular degeneration and Alzheimer’s. Treatment for fungal and multiple viral infections, includin...

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Realtime, continuous assessment of complex-mixture protease and protease inhibitor activity

Publication Type: Academic Journal

Source(s): 4 open, Vol 5, p 11 (2022)

Abstract: Recently the treatment PAXLOVID™ (nirmatrelvir co-packaged with ritonavir) was authorized for use as a treatment for COVID-19. The presumed mechanism of action of the treatment, an inhibitor of a Sars-Cov-2 “3CL” protease, continues decades-long intere...

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The SOD1-mediated ALS phenotype shows a decoupling between age of symptom onset and disease duration

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-9 (2022)

Abstract: Analysis of age of onset and disease duration in a large, international cohort of people with SOD1-ALS shows that there is a distinct phenotype and that onset and progression are decoupled.

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Cost and cost-effectiveness of the ‘Stand and Move at Work’ multicomponent intervention to reduce workplace sedentary time and cardiometabolic risk

Publication Type: Academic Journal

Source(s): Scandinavian Journal of Work, Environment & Health, Vol 48, Iss 5, Pp 399-409 (2022)

Abstract: OBJECTIVE: Few studies have reported the cost and cost-effectiveness of workplace interventions to reduce sedentary time. The purpose of this study was to complete an economic evaluation of a multilevel intervention to reduce sitting time and increase ...

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Development and evaluation of a collaborative care intervention for male prison leavers with mental health problems: the Engager research programme

Publication Type: Academic Journal

Source(s): Programme Grants for Applied Research, Vol 10, Iss 8 (2022)

Abstract: Background: Many male prison leavers have significant mental health problems. Prison leavers often have a history of trauma, ongoing substance misuse and housing insecurity. Only a minority of prison leavers receive mental health care on release from p...

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Surface interfacial analysis of simulant high level nuclear waste glass dissolved in synthetic cement solutions

Publication Type: Academic Journal

Source(s): npj Materials Degradation, Vol 6, Iss 1, Pp 1-14 (2022)

Abstract: Abstract The corrosion mechanisms and kinetics of a Mg-rich alkali aluminoborosilicate glass simulating UK high-level waste (CaZn28) were investigated upon dissolution in synthetic cement solutions. Dissolution varied as a function the different pH and...

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Evidence of cerebellar TDP-43 loss of function in FTLD-TDP

Publication Type: Academic Journal

Source(s): Acta Neuropathologica Communications, Vol 10, Iss 1, Pp 1-9 (2022)

Abstract: Abstract Frontotemporal lobar degeneration with TDP-43 pathology (FTLD-TDP) is a neurodegenerative disease primarily affecting the frontal and/or temporal cortices. However, a growing body of evidence suggests that the cerebellum contributes to biochem...

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Free the Internet.

Publication Type: Review

Source(s): New Republic; Oct2022, Vol. 253 Issue 10, p60-63, 4p, 1 Illustration

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Mobility of polypropylene microplastics in stormwater biofilters under freeze-thaw cycles

Publication Type: Academic Journal

Source(s): Journal of Hazardous Materials Letters, Vol 3, Iss , Pp 100048- (2022)

Abstract: Stormwater biofilters naturally experience dry-wet and freeze-thaw cycles, which could remobilize deposited particulate pollutants including microplastics. Yet, the effect of these natural weathering conditions on the mobility of deposited microplastic...

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