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Protocol for PPP1R15A-inhibited mouse model establishment with subcutaneous B16F1 tumor and single-cell analysis
Publication Type: Academic Journal
Source(s): STAR Protocols, Vol 4, Iss 4, Pp 102616- (2023)
Abstract: Summary: Here, we present a protocol for exploring the effects of PPP1R15A inhibitor, Sephin1, on antitumor immunity of B16F1 subcutaneous tumor in mice. We describe steps for constructing single-cell transcriptome and TCR libraries, sequencing, and us...
Vitamin D receptor (VDR) on the cell membrane of mouse macrophages participates in the formation of lipopolysaccharide tolerance: mVDR is related to the effect of artesunate to reverse LPS tolerance
Publication Type: Academic Journal
Source(s): Cell Communication and Signaling, Vol 21, Iss 1, Pp 1-17 (2023)
Abstract: Abstract It is unclear whether membrane vitamin D receptor (mVDR) exists on the macrophage membrane or whether mVDR is associated with lipopolysaccharide (LPS) tolerance. Herein, we report that interfering with caveolae and caveolae-dependent lipid raf...
Covalent inhibitor targets KRasG12C: A new paradigm for drugging the undruggable and challenges ahead
Publication Type: Academic Journal
Source(s): Genes and Diseases, Vol 10, Iss 2, Pp 403-414 (2023)
Abstract: KRAS is one of the most commonly mutated oncogenes in cancers and therapeutics directly targeting the KRas have been challenging. Among the different known mutants, KRasG12C has been proved to be successfully targeted recently. Several covalent inhibit...
Quality Changes of Kung Pao Chicken during Cooking
Publication Type: Academic Journal
Source(s): Shipin gongye ke-ji, Vol 44, Iss 4, Pp 189-197 (2023)
Abstract: According to the processing technology of Kung Pao Chicken, the changes of color, texture and volatile flavor compounds of Kung Pao Chicken during cooking (stir-frying 0, 2, 4, 6 and 8 min) were studied by colorimeter, texture analyzer and gas chromato...
Exosomes Derived from Hypoxia-Cultured Human Adipose Stem Cells Alleviate Articular Chondrocyte Inflammaging and Post-Traumatic Osteoarthritis Progression.
Publication Type: Academic Journal
Source(s): International Journal of Molecular Sciences. Sep2023, Vol. 24 Issue 17, p13414. 22p.
Abstract: Osteoarthritis (OA) is the most common age-related degenerative joint disease. Inflammaging, linking inflammation and aging, is found in senescent cells with the secretions of matrix-degrading proteins and proinflammatory cytokines. The senescence-asso...
Exosomes Derived from Hypoxia-Cultured Human Adipose Stem Cells Alleviate Articular Chondrocyte Inflammaging and Post-Traumatic Osteoarthritis Progression
Publication Type: Academic Journal
Source(s): International Journal of Molecular Sciences, Vol 24, Iss 17, p 13414 (2023)
Abstract: Osteoarthritis (OA) is the most common age-related degenerative joint disease. Inflammaging, linking inflammation and aging, is found in senescent cells with the secretions of matrix-degrading proteins and proinflammatory cytokines. The senescence-asso...
Single-cell RNA sequencing reveals the suppressive effect of PPP1R15A inhibitor Sephin1 in antitumor immunity
Publication Type: Academic Journal
Source(s): iScience, Vol 26, Iss 2, Pp 105954- (2023)
Abstract: Summary: Protein phosphatase 1 regulatory subunit 15A (PPP1R15A) is an important factor in the integrated stress response (ISR) in mammals and may play a crucial role in tumorigenesis. In our studies, we found an inhibitor of PPP1R15A, Sephin1, plays a...
On Decoder Ties for the Binary Symmetric Channel with Arbitrarily Distributed Input
Publication Type: Academic Journal
Source(s): Entropy, Vol 25, Iss 4, p 668 (2023)
Abstract: The error probability of block codes sent under a non-uniform input distribution over the memoryless binary symmetric channel (BSC) and decoded via the maximum a posteriori (MAP) decoding rule is investigated. It is proved that the ratio of the probabi...
On Decoder Ties for the Binary Symmetric Channel with Arbitrarily Distributed Input.
Publication Type: Academic Journal
Source(s): Entropy. Apr2023, Vol. 25 Issue 4, p668. 23p.
Abstract: The error probability of block codes sent under a non-uniform input distribution over the memoryless binary symmetric channel (BSC) and decoded via the maximum a posteriori (MAP) decoding rule is investigated. It is proved that the ratio of the probabi...
Efficacy and safety of long-term transcutaneous electroacupuncture versus sham transcutaneous electroacupuncture for delayed gastric emptying after distal gastrectomy: study protocol for a randomized, patient-assessor blinded, controlled trial
Publication Type: Academic Journal
Source(s): Trials, Vol 23, Iss 1, Pp 1-9 (2022)
Abstract: Abstract Background Delayed gastric emptying (DGE) after distal gastrectomy impacts patients’ nutritional status and quality of life. The current treatments of DGE seem unsatisfactory or need invasive interventions. It is unknown whether transcutaneous...