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 "Linkens AMA"
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Pyridoxamine reduces methylglyoxal and markers of glycation and endothelial dysfunction, but does not improve insulin sensitivity or vascular function in abdominally obese individuals: A randomized double-blind placebo-controlled trial.

Publication Type: Academic Journal

Source(s): Diabetes, obesity & metabolism [Diabetes Obes Metab] 2023 May; Vol. 25 (5), pp. 1280-1291. Date of Electronic Publication: 2023 Feb 14.

Abstract: Aim: To investigate the effects of pyridoxamine (PM), a B6 vitamer and dicarbonyl scavenger, on glycation and a large panel of metabolic and vascular measurements in a randomized double-blind placebo-controlled trial in abdominally obese individuals.Ma...

A 4-Week Diet Low or High in Advanced Glycation Endproducts Has Limited Impact on Gut Microbial Composition in Abdominally Obese Individuals: The deAGEing Trial.

Publication Type: Academic Journal

Source(s): International journal of molecular sciences [Int J Mol Sci] 2022 May 10; Vol. 23 (10). Date of Electronic Publication: 2022 May 10.

Abstract: Dietary advanced glycation endproducts (AGEs), abundantly present in Westernized diets, are linked to negative health outcomes, but their impact on the gut microbiota has not yet been well investigated in humans. We investigated the effects of a 4-week...

Habitual intake of dietary advanced glycation end products is not associated with generalized microvascular function-the Maastricht Study.

Publication Type: Academic Journal

Source(s): The American journal of clinical nutrition [Am J Clin Nutr] 2022 Feb 09; Vol. 115 (2), pp. 444-455.

Abstract: Background: Endogenously formed advanced glycation end products (AGEs) may be important drivers of microvascular dysfunction and the microvascular complications of diabetes. AGEs are also formed in food products, especially during preparation methods i...

Dietary advanced glycation endproducts (AGEs) increase their concentration in plasma and tissues, result in inflammation and modulate gut microbial composition in mice; evidence for reversibility.

Publication Type: Academic Journal

Source(s): Food research international (Ottawa, Ont.) [Food Res Int] 2021 Sep; Vol. 147, pp. 110547. Date of Electronic Publication: 2021 Jun 18.

Abstract: Scope: Dietary advanced glycation endproducts (AGEs) are associated with negative biological effects, possibly due to accumulation in plasma and tissues and through modulation of inflammation and gut microbiota. Whether these biological consequences ar...