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Advanced Search Results For "Lynch, Marc"

1 - 10 of 835 results for
 "Lynch, Marc"
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Implementing a pragmatic clinical trial to tailor opioids for acute pain on behalf of the IGNITE ADOPT PGx investigators

Publication Type: Academic Journal

Source(s): Clinical and Translational Science, Vol 15, Iss 10, Pp 2479-2492 (2022)

Abstract: Abstract Opioid prescribing for postoperative pain management is challenging because of inter‐patient variability in opioid response and concern about opioid addiction. Tramadol, hydrocodone, and codeine depend on the cytochrome P450 2D6 (CYP2D6) enzym...

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Mental health and visual acuity in patients with age-related macular degeneration

Publication Type: Academic Journal

Source(s): BMC Ophthalmology, Vol 22, Iss 1, Pp 1-11 (2022)

Abstract: Abstract Background Visual acuity (VA) loss has been associated with depression in patients with age-related macular degeneration (AMD). However, previous studies did not incorporate subgroups of AMD when correlating VA and mental health. The goal of t...

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International cohort study indicates no association between alpha-1 blockers and susceptibility to COVID-19 in benign prostatic hyperplasia patients

Publication Type: Academic Journal

Source(s): Frontiers in Pharmacology, Vol 13 (2022)

Abstract: Purpose: Alpha-1 blockers, often used to treat benign prostatic hyperplasia (BPH), have been hypothesized to prevent COVID-19 complications by minimising cytokine storm release. The proposed treatment based on this hypothesis currently lacks support fr...

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Gender as an effect modifier in the relationship between hypertension and reticular pseudodrusen in patients with early or intermediate age-related macular degeneration

Publication Type: Academic Journal

Source(s): International Journal of Ophthalmology, Vol 15, Iss 3, Pp 461-465 (2022)

Abstract: AIM: To determine whether the prevalence of treated hypertension is higher among males or females with early/intermediate (e/i) age-related macular degeneration (AMD) with and without bilateral reticular pseudodrusen (RPD). METHODS: Retrospective revie...

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Seek COVER: using a disease proxy to rapidly develop and validate a personalized risk calculator for COVID-19 outcomes in an international network

Publication Type: Academic Journal

Source(s): BMC Medical Research Methodology, Vol 22, Iss 1, Pp 1-13 (2022)

Abstract: Abstract Background We investigated whether we could use influenza data to develop prediction models for COVID-19 to increase the speed at which prediction models can reliably be developed and validated early in a pandemic. We developed COVID-19 Estima...

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Post-Operative Functional Outcomes in Early Age Onset Rectal Cancer

Publication Type: Academic Journal

Source(s): Frontiers in Oncology, Vol 12 (2022)

Abstract: BackgroundImpairment of bowel, urogenital and fertility-related function in patients treated for rectal cancer is common. While the rate of rectal cancer in the young (

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Emergency conservation interventions during times of crisis: A case study for a threatened bird species in the Australian Black Summer bushfires

Publication Type: Academic Journal

Source(s): Conservation Science and Practice, Vol 4, Iss 2, Pp n/a-n/a (2022)

Abstract: Abstract Emergency conservation interventions will be increasingly necessary to prevent extinctions or severe population bottlenecks as extreme events become more frequent. We detail the emergency extraction of the endangered Eastern Bristlebird (Dasyo...

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Genomic characterisation of an entomopathogenic strain of Serratia ureilytica in the critically endangered phasmid Dryococelus australis

Publication Type: Academic Journal

Source(s): PLoS ONE, Vol 17, Iss 4 (2022)

Abstract: Between 2014 and 2019, unexpected mortalities were observed in a colony of Dryococelus australis, an endangered stick-insect kept at the Melbourne Zoo for a breeding and conservation program. Pure cultures of Serratia spp. were obtained from the haemol...

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An Old Pathogen in a New Environment–Implications of Coxiella burnetii in Australian Fur Seals (Arctocephalus pusillus doriferus)

Publication Type: Academic Journal

Source(s): Frontiers in Marine Science, Vol 9 (2022)

Abstract: The Australian fur seal (Arctocephalus pusillus doriferus) has experienced a slower than expected population recovery since the end of the commercial sealing era, with a high third trimester abortion rate. There is currently no known proximate cause. C...

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The impact of viral mutations on recognition by SARS-CoV-2 specific T cells

Publication Type: Academic Journal

Source(s): iScience, Vol 24, Iss 11, Pp 103353- (2021)

Abstract: Summary: We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of reco...

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