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Application of high-throughput single-nucleus DNA sequencing in pancreatic cancer
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)
Abstract: Implementing high-throughput single-cell DNA sequencing for the study of solid tumours has been challenging. Here, the authors present an optimised approach for snap-frozen tissue single nuclei extraction and DNA sequencing, which can be applied to stu...
Evidence for reduced BRCA2 functional activity in Homo sapiens after divergence from the chimpanzee-human last common ancestor
Publication Type: Academic Journal
Source(s): Cell Reports, Vol 39, Iss 5, Pp 110771- (2022)
Abstract: Summary: We performed a comparative analysis of human and 12 non-human primates to identify sequence variations in known cancer genes. We identified 395 human-specific fixed non-silent substitutions that emerged during evolution of human. Using bioinfo...
Pancreatic cancer prognosis is predicted by an ATAC-array technology for assessing chromatin accessibility
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Abstract: ATAC-seq allows for the investigation of chromatin accessibility, a feature which can have important implications for gene regulation. Here the authors present ATAC-array to assess accessibility in human tumours and based on this predict disease progno...
Extensive three-dimensional intratumor proteomic heterogeneity revealed by multiregion sampling in high-grade serous ovarian tumor specimens
Publication Type: Academic Journal
Source(s): iScience, Vol 24, Iss 7, Pp 102757- (2021)
Abstract: Summary: Enriched tumor epithelium, tumor-associated stroma, and whole tissue were collected by laser microdissection from thin sections across spatially separated levels of ten high-grade serous ovarian carcinomas (HGSOCs) and analyzed by mass spectro...
Accelerated single cell seeding in relapsed multiple myeloma
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Abstract: In multiple myeloma, disease progresses via seeding to different anatomic sites and clonal expansion. Here, utilising autopsy material, the authors show that systemic seeding accelerates at relapse following treatment.
Characterization of genetic subclonal evolution in pancreatic cancer mouse models
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 10, Iss 1, Pp 1-10 (2019)
Abstract: In pancreatic cancer the Kras and Trp53 transgene driven KPC mouse model is used to experimentally study disease processes. Here, the authors analyse tumour evolution within the KPC model, finding both linear and branched evolution and highlighting the...
Intratumoral and Microenvironmental Heterogeneity in Patient Outcome Prediction.
Publication Type: Academic Journal
Source(s): JCO Precision Oncology; 2/27/2023, Vol. 7, p1-3, 3p
Author Correction: Accelerated single cell seeding in relapsed multiple myeloma
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Abstract: A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-20978-y.
Reconstructing metastatic seeding patterns of human cancers
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 8, Iss 1, Pp 1-10 (2017)
Abstract: Tumours frequently metastasize to multiple anatomical sites and understanding how these different metastases evolve may be important for therapy. Here, the authors develop a method—Treeomics—that can construct phylogenies from multiple metastases from ...
Neoantigen quality predicts immunoediting in survivors of pancreatic cancer.
Publication Type: Academic Journal
Source(s): Nature; 6/9/2022, Vol. 606 Issue 7913, p389-395, 7p
Abstract: Copyright of Nature is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articl...