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Advanced Search Results For "Marcus Koch"

1 - 10 of 1,557 results for
 "Marcus Koch"
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Givinostat-Liposomes: Anti-Tumor Effect on 2D and 3D Glioblastoma Models and Pharmacokinetics

Publication Type:Academic Journal

Source(s):Cancers, Vol 14, Iss 2978, p 2978 (2022)

Abstract:Glioblastoma is the most common and aggressive brain tumor, associated with poor prognosis and survival, representing a challenging medical issue for neurooncologists. Dysregulation of histone-modifying enzymes (HDACs) is commonly identified in many tu...

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Micro-mechanical response of ultrafine grain and nanocrystalline tantalum

Publication Type:Academic Journal

Source(s):Journal of Materials Research and Technology, Vol 12, Iss , Pp 1804-1815 (2021)

Abstract:In order to investigate the effect of grain boundaries on the mechanical response in the micrometer and submicrometer levels, complementary experiments and molecular dynamics simulations were conducted on a model bcc metal, tantalum. Microscale pillar ...

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Optical detection of di- and triphosphate anions with mixed monolayer-protected gold nanoparticles containing zinc(II)–dipicolylamine complexes

Publication Type:Academic Journal

Source(s):Beilstein Journal of Organic Chemistry, Vol 16, Iss 1, Pp 2687-2700 (2020)

Abstract:Gold nanoparticles covered with a mixture of ligands of which one type contains solubilizing triethylene glycol residues and the other peripheral zinc(II)–dipicolylamine (DPA) complexes allowed the optical detection of hydrogenphosphate, diphosphate, a...

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A New PqsR Inverse Agonist Potentiates Tobramycin Efficacy to Eradicate Pseudomonas aeruginosa Biofilms

Publication Type:Academic Journal

Source(s):Advanced Science, Vol 8, Iss 12, Pp n/a-n/a (2021)

Abstract:Abstract Pseudomonas aeruginosa (PA) infections can be notoriously difficult to treat and are often accompanied by the development of antimicrobial resistance (AMR). Quorum sensing inhibitors (QSI) acting on PqsR (MvfR) – a crucial transcriptional regu...

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Advanced Analysis of Diffusion Tensor Imaging Along With Machine Learning Provides New Sensitive Measures of Tissue Pathology and Intra-Lesion Activity in Multiple Sclerosis

Publication Type:Academic Journal

Source(s):Frontiers in Neuroscience, Vol 15 (2021)

Abstract:Tissue pathology in multiple sclerosis (MS) is highly complex, requiring multi-dimensional analysis. In this study, our goal was to test the feasibility of obtaining high angular resolution diffusion imaging (HARDI) metrics through single-shell modelin...

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Bacteriomimetic Liposomes Improve Antibiotic Activity of a Novel Energy-Coupling Factor Transporter Inhibitor

Publication Type:Academic Journal

Source(s):Pharmaceutics, Vol 14, Iss 4, p 4 (2021)

Abstract:Liposomes have been studied for decades as nanoparticulate drug delivery systems for cytostatics, and more recently, for antibiotics. Such nanoantibiotics show improved antibacterial efficacy compared to the free drug and can be effective despite bacte...

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Scanning electron microscopy preparation of the cellular actin cortex: A quantitative comparison between critical point drying and hexamethyldisilazane drying.

Publication Type:Academic Journal

Source(s):PLoS ONE, Vol 16, Iss 7, p e0254165 (2021)

Abstract:The cellular cortex is an approximately 200-nm-thick actin network that lies just beneath the cell membrane. It is responsible for the mechanical properties of cells, and as such, it is involved in many cellular processes, including cell migration and ...

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A complete digitization of German herbaria is possible, sensible and should be started now

Publication Type:Academic Journal

Source(s):Research Ideas and Outcomes, Vol 6, Iss , Pp 1-27 (2020)

Abstract:Plants, fungi and algae are important components of global biodiversity and are fundamental to all ecosystems. They are the basis for human well-being, providing food, materials and medicines. Specimens of all three groups of organisms are accommodated...

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Synthesis and Biopharmaceutical Characterization of Amphiphilic Squalenyl Derivative Based Versatile Drug Delivery Platform

Publication Type:Academic Journal

Source(s):Frontiers in Chemistry, Vol 8 (2020)

Abstract:Limited drug loading capacity (LC), mostly below 5% w/w, is a significant drawback of nanoparticulate drug delivery systems (DDS). Squalenoylation technology, which employs bioconjugation of squalenyl moiety and drug, allows self-assemble of nanopartic...

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The synergistic effect of chlorotoxin-mApoE in boosting drug-loaded liposomes across the BBB

Publication Type:Academic Journal

Source(s):Journal of Nanobiotechnology, Vol 17, Iss 1, Pp 1-7 (2019)

Abstract:Abstract We designed liposomes dually functionalized with ApoE-derived peptide (mApoE) and chlorotoxin (ClTx) to improve their blood–brain barrier (BBB) crossing. Our results demonstrated the synergistic activity of ClTx-mApoE in boosting doxorubicin-l...

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