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Advanced Search Results For "Mark S Graham, PhD"

1 - 10 of 13 results for
 "Mark S Graham, PhD"
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Changes in symptomatology, reinfection, and transmissibility associated with the SARS-CoV-2 variant B.1.1.7: an ecological study

Publication Type: Academic Journal

Source(s): The Lancet Public Health, Vol 6, Iss 5, Pp e335-e345 (2021)

Abstract: Summary: Background: The SARS-CoV-2 variant B.1.1.7 was first identified in December, 2020, in England. We aimed to investigate whether increases in the proportion of infections with this variant are associated with differences in symptoms or disease c...

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Implementation of corticosteroids in treatment of COVID-19 in the ISARIC WHO Clinical Characterisation Protocol UK: prospective, cohort study

Publication Type: Academic Journal

Source(s): The Lancet: Digital Health, Vol 4, Iss 4, Pp e220-e234 (2022)

Abstract: Summary: Background: Dexamethasone was the first intervention proven to reduce mortality in patients with COVID-19 being treated in hospital. We aimed to evaluate the adoption of corticosteroids in the treatment of COVID-19 in the UK after the RECOVERY...

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Grand Challenges in global eye health: a global prioritisation process using Delphi method

Publication Type: Academic Journal

Source(s): The Lancet. Healthy Longevity, Vol 3, Iss 1, Pp e31-e41 (2022)

Abstract: Summary: Background: We undertook a Grand Challenges in Global Eye Health prioritisation exercise to identify the key issues that must be addressed to improve eye health in the context of an ageing population, to eliminate persistent inequities in heal...

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Global, regional, and national estimates of the population at increased risk of severe COVID-19 due to underlying health conditions in 2020: a modelling study

Publication Type: Academic Journal

Source(s): The Lancet Global Health, Vol 8, Iss 8, Pp e1003-e1017 (2020)

Abstract: Summary: Background: The risk of severe COVID-19 if an individual becomes infected is known to be higher in older individuals and those with underlying health conditions. Understanding the number of individuals at increased risk of severe COVID-19 and ...

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Effects of non-pharmaceutical interventions on COVID-19 cases, deaths, and demand for hospital services in the UK: a modelling study

Publication Type: Academic Journal

Source(s): The Lancet Public Health, Vol 5, Iss 7, Pp e375-e385 (2020)

Abstract: Summary: Background: Non-pharmaceutical interventions have been implemented to reduce transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the UK. Projecting the size of an unmitigated epidemic and the potential effect of dif...

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Quarantine and testing strategies in contact tracing for SARS-CoV-2: a modelling study

Publication Type: Academic Journal

Source(s): The Lancet Public Health, Vol 6, Iss 3, Pp e175-e183 (2021)

Abstract: Summary: Background: In most countries, contacts of confirmed COVID-19 cases are asked to quarantine for 14 days after exposure to limit asymptomatic onward transmission. While theoretically effective, this policy places a substantial social and econom...

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Histopathological findings and viral tropism in UK patients with severe fatal COVID-19: a post-mortem study

Publication Type: Academic Journal

Source(s): The Lancet Microbe, Vol 1, Iss 6, Pp e245-e253 (2020)

Abstract: Summary: Background: Severe COVID-19 has a high mortality rate. Comprehensive pathological descriptions of COVID-19 are scarce and limited in scope. We aimed to describe the histopathological findings and viral tropism in patients who died of severe CO...

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Anatomic position determines oncogenic specificity in melanoma.

Publication Type: Academic Journal

Source(s): Nature [Nature] 2022 Apr; Vol. 604 (7905), pp. 354-361. Date of Electronic Publication: 2022 Mar 30.

Abstract: Oncogenic alterations to DNA are not transforming in all cellular contexts 1,2 . This may be due to pre-existing transcriptional programmes in the cell of origin. Here we define anatomic position as a major determinant of why cells respond to specific ...

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PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation.

Publication Type: Academic Journal

Source(s): Nature communications [Nat Commun] 2022 Feb 01; Vol. 13 (1), pp. 604. Date of Electronic Publication: 2022 Feb 01.

Abstract: The role of PPM1D mutations in de novo gliomagenesis has not been systematically explored. Here we analyze whole genome sequences of 170 pediatric high-grade gliomas and find that truncating mutations in PPM1D that increase the stability of its phospha...

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Costs of the police service and mental healthcare pathways experienced by individuals with enduring mental health needs.

Publication Type: Academic Journal

Source(s): The British journal of psychiatry : the journal of mental science [Br J Psychiatry] 2017 Feb; Vol. 210 (2), pp. 157-164. Date of Electronic Publication: 2016 Mar 17.

Abstract: Background: Substantial policy, communication and operational gaps exist between mental health services and the police for individuals with enduring mental health needs.Aims: To map and cost pathways through mental health and police services, and to mo...

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