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Advanced Search Results For "Mattei, Michael D."

1 - 10 of 108 results for
 "Mattei, Michael D."
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The Cancer Genome Atlas Comprehensive Molecular Characterization of Renal Cell Carcinoma

Publication Type: Academic Journal

Source(s): Cell Reports, Vol 23, Iss 1, Pp 313-326.e5 (2018)

Abstract: Summary: Renal cell carcinoma (RCC) is not a single disease, but several histologically defined cancers with different genetic drivers, clinical courses, and therapeutic responses. The current study evaluated 843 RCC from the three major histologic sub...

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Driver Fusions and Their Implications in the Development and Treatment of Human Cancers

Publication Type: Academic Journal

Source(s): Cell Reports, Vol 23, Iss 1, Pp 227-238.e3 (2018)

Abstract: Summary: Gene fusions represent an important class of somatic alterations in cancer. We systematically investigated fusions in 9,624 tumors across 33 cancer types using multiple fusion calling tools. We identified a total of 25,664 fusions, with a 63% ...

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Spatial Organization and Molecular Correlation of Tumor-Infiltrating Lymphocytes Using Deep Learning on Pathology Images

Publication Type: Academic Journal

Source(s): Cell Reports, Vol 23, Iss 1, Pp 181-193.e7 (2018)

Abstract: Summary: Beyond sample curation and basic pathologic characterization, the digitized H&E-stained images of TCGA samples remain underutilized. To highlight this resource, we present mappings of tumor-infiltrating lymphocytes (TILs) based on H&E images f...

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Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers

Publication Type: Academic Journal

Source(s): Cell Reports, Vol 23, Iss 1, Pp 255-269.e4 (2018)

Abstract: Summary: Metabolic reprogramming provides critical information for clinical oncology. Using molecular data of 9,125 patient samples from The Cancer Genome Atlas, we identified tumor subtypes in 33 cancer types based on mRNA expression patterns of seven...

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Systematic Analysis of Splice-Site-Creating Mutations in Cancer

Publication Type: Academic Journal

Source(s): Cell Reports, Vol 23, Iss 1, Pp 270-281.e3 (2018)

Abstract: Summary: For the past decade, cancer genomic studies have focused on mutations leading to splice-site disruption, overlooking those having splice-creating potential. Here, we applied a bioinformatic tool, MiSplice, for the large-scale discovery of spli...

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Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas

Publication Type: Academic Journal

Source(s): Cell Reports, Vol 23, Iss 1, Pp 239-254.e6 (2018)

Abstract: Summary: DNA damage repair (DDR) pathways modulate cancer risk, progression, and therapeutic response. We systematically analyzed somatic alterations to provide a comprehensive view of DDR deficiency across 33 cancer types. Mutations with accompanying ...

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Somatic Mutational Landscape of Splicing Factor Genes and Their Functional Consequences across 33 Cancer Types

Publication Type: Academic Journal

Source(s): Cell Reports, Vol 23, Iss 1, Pp 282-296.e4 (2018)

Abstract: Summary: Hotspot mutations in splicing factor genes have been recently reported at high frequency in hematological malignancies, suggesting the importance of RNA splicing in cancer. We analyzed whole-exome sequencing data across 33 tumor types in The C...

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Machine Learning Detects Pan-cancer Ras Pathway Activation in The Cancer Genome Atlas

Publication Type: Academic Journal

Source(s): Cell Reports, Vol 23, Iss 1, Pp 172-180.e3 (2018)

Abstract: Summary: Precision oncology uses genomic evidence to match patients with treatment but often fails to identify all patients who may respond. The transcriptome of these “hidden responders” may reveal responsive molecular states. We describe and evaluate...

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Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

Publication Type: Academic Journal

Source(s): Cell Reports, Vol 23, Iss 1, Pp 297-312.e12 (2018)

Abstract: Summary: Long noncoding RNAs (lncRNAs) are commonly dysregulated in tumors, but only a handful are known to play pathophysiological roles in cancer. We inferred lncRNAs that dysregulate cancer pathways, oncogenes, and tumor suppressors (cancer genes) b...

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Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types

Publication Type: Academic Journal

Source(s): Cell Reports, Vol 23, Iss 1, Pp 213-226.e3 (2018)

Abstract: Summary: Protein ubiquitination is a dynamic and reversible process of adding single ubiquitin molecules or various ubiquitin chains to target proteins. Here, using multidimensional omic data of 9,125 tumor samples across 33 cancer types from The Cance...

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