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Validation of the inflammatory bowel disease disability index for self-report and development of an item-reduced version.
Publication Type: Academic Journal
Source(s): Journal of gastroenterology and hepatology [J Gastroenterol Hepatol] 2019 Jan; Vol. 34 (1), pp. 92-102. Date of Electronic Publication: 2018 Oct 25.
Abstract: Background and Aim: The Inflammatory Bowel Disease Disability Index (IBD-DI) is a measure of disability in inflammatory bowel disease (IBD). The IBD-DI is validated for use as a clinical interview but not for use as a self-report questionnaire. We aime...
Mutations in the pancreatic secretory enzymes CPA1 and CPB1 are associated with pancreatic cancer.
Publication Type: Academic Journal
Source(s): Proceedings of the National Academy of Sciences of the United States of America [Proc Natl Acad Sci U S A] 2018 May 01; Vol. 115 (18), pp. 4767-4772. Date of Electronic Publication: 2018 Apr 18.
Abstract: To evaluate whether germline variants in genes encoding pancreatic secretory enzymes contribute to pancreatic cancer susceptibility, we sequenced the coding regions of CPB1 and other genes encoding pancreatic secretory enzymes and known pancreatitis su...
Disability in Restorative Proctocolectomy Recipients Measured using the Inflammatory Bowel Disease Disability Index.
Publication Type: Academic Journal
Source(s): Journal of Crohn's & colitis [J Crohns Colitis] 2016 Dec; Vol. 10 (12), pp. 1378-1384. Date of Electronic Publication: 2016 Jun 09.
Abstract: Background and Aims: The inflammatory bowel disease [IBD] disability index [IBD-DI], which measures IBD-associated disability, has been validated on IBD patients but not those who have had restorative proctocolectomy with ileal pouch-anal anastomosis [...
Whole Genome Sequencing Defines the Genetic Heterogeneity of Familial Pancreatic Cancer.
Publication Type: Academic Journal
Source(s): Cancer discovery [Cancer Discov] 2016 Feb; Vol. 6 (2), pp. 166-75. Date of Electronic Publication: 2015 Dec 09.
Abstract: Unlabelled: Pancreatic cancer is projected to become the second leading cause of cancer-related death in the United States by 2020. A familial aggregation of pancreatic cancer has been established, but the cause of this aggregation in most families is ...
Non-aromatic A-ring replacement in the triaryl bis-sulfone CB2 receptor inhibitors.
Publication Type: Academic Journal
Source(s): Bioorganic & medicinal chemistry letters [Bioorg Med Chem Lett] 2010 Jan 15; Vol. 20 (2), pp. 608-11. Date of Electronic Publication: 2009 Nov 22.
Abstract: The triaryl bis-sulfone 1 was modified by converting the aryl A-ring to a piperidine ring. The piperidine ring was further elaborated to a spirocyclopropyl piperidine moiety. The effect on CB2 binding potency, rat calcium channel affinity, and CYP 2C9 ...
Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model.
Publication Type: Academic Journal
Source(s): Cancer cell [Cancer Cell] 2009 Oct 06; Vol. 16 (4), pp. 324-35.
Abstract: Short hairpin RNAs (shRNAs) capable of stably suppressing gene function by RNA interference (RNAi) can mimic tumor-suppressor-gene loss in mice. By selecting for shRNAs capable of accelerating lymphomagenesis in a well-characterized mouse lymphoma mode...
Genome-wide transposon tagging reveals location-dependent effects on transcription and chromatin organization in Arabidopsis.
Publication Type: Academic Journal
Source(s): The Plant journal : for cell and molecular biology [Plant J] 2008 Aug; Vol. 55 (3), pp. 514-25. Date of Electronic Publication: 2008 Apr 12.
Abstract: The interphase nucleus exists as a highly dynamic system, the physical properties of which have functional importance in gene regulation. Not only can gene expression be influenced by the local sequence context, but also by the architecture of the nucl...
High-content analysis of cancer genome DNA alterations.
Publication Type: Academic Journal
Source(s): Current opinion in genetics & development [Curr Opin Genet Dev] 2008 Feb; Vol. 18 (1), pp. 68-72. Date of Electronic Publication: 2008 Mar 12.
Abstract: New technologies as well as concerted brute-force approaches have increased the content (number of genes) that can be characterized for genomic DNA alterations. Recent advances include the detection of activating point mutations in key kinase genes (BR...
The Rice Annotation Project Database (RAP-DB): 2008 update.
Publication Type: Academic Journal
Source(s): Nucleic acids research [Nucleic Acids Res] 2008 Jan; Vol. 36 (Database issue), pp. D1028-33. Date of Electronic Publication: 2007 Dec 17.
Abstract: The Rice Annotation Project Database (RAP-DB) was created to provide the genome sequence assembly of the International Rice Genome Sequencing Project (IRGSP), manually curated annotation of the sequence, and other genomics information that could be use...
Massively parallel bisulphite pyrosequencing reveals the molecular complexity of breast cancer-associated cytosine-methylation patterns obtained from tissue and serum DNA.
Publication Type: Academic Journal
Source(s): Genome research [Genome Res] 2008 Jan; Vol. 18 (1), pp. 19-29. Date of Electronic Publication: 2007 Nov 21.
Abstract: Cytosine-methylation changes are stable and thought to be among the earliest events in tumorigenesis. Theoretically, DNA carrying tumor-specifying methylation patterns escape the tumors and may be found circulating in the sera from cancer patients, thu...