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    • Oleoylethanolamide facilitates PPARα and TFEB signaling and attenuates Aβ pathology in a mouse model of Alzheimer’s disease

    Publication Type: Academic Journal

    Source(s): Molecular Neurodegeneration, Vol 18, Iss 1, Pp 1-19 (2023)

    Abstract: Abstract Background Age is the strongest risk factor for the development of Alzheimer’s disease (AD). Besides the pathological hallmarks of β-amyloid (Aβ) plaques and neurofibrillary tangles, emerging evidence demonstrates a critical role of microglia ...

    Association Between Sensitivity to Thyroid Hormones and Metabolic Dysfunction-Associated Fatty Liver Disease in Euthyroid Subjects: A Cross-Sectional Study

    Publication Type: Academic Journal

    Source(s): Diabetes, Metabolic Syndrome and Obesity, Vol Volume 16, Pp 2153-2163 (2023)

    Authors:

    Abstract: Huanxin Liu,1 Yuling Xing,2 Qian Nie,1 Zhong Li,3 Cuiqiao Meng,1 Huijuan Ma2,4 1Health Examination Center, Hebei General Hospital, Shijiazhuang, Hebei, 050051, People’s Republic of China; 2Department of Endocrinology, Hebei General Hospital, Shijiazhua...

    Relationship Between Estimated Glucose Disposal Rate and Type 2 Diabetic Retinopathy

    Publication Type: Academic Journal

    Source(s): Diabetes, Metabolic Syndrome and Obesity, Vol Volume 16, Pp 807-818 (2023)

    Authors:

    Abstract: Cuiqiao Meng,1 Yuling Xing,2,3 Lijing Huo,4 Huijuan Ma2,5,6 1Health Examination Center, Hebei General Hospital, Shijiazhuang, People’s Republic of China; 2Department of Endocrinology, Hebei General Hospital, Shijiazhuang, People’s Republic of China; 3G...

    Complement C3aR depletion reverses HIF-1α–induced metabolic impairment and enhances microglial response to Aβ pathology

    Publication Type: Academic Journal

    Source(s): The Journal of Clinical Investigation, Vol 133, Iss 12 (2023)

    Abstract: Microglia are the major cell type expressing complement C3a receptor (C3aR) in the brain. Using a knockin mouse line in which a Td-tomato reporter is incorporated into the endogenous C3ar1 locus, we identified 2 major subpopulations of microglia with d...

    Osteocyte-specific dentin matrix protein 1: the role of mineralization regulation in low-magnitude high-frequency vibration enhanced osteoporotic fracture healing

    Publication Type: Academic Journal

    Source(s): Bone & Joint Research, Vol 11, Iss 7, Pp 465-476 (2022)

    Abstract: Aims: There is an increasing concern of osteoporotic fractures in the ageing population. Low-magnitude high-frequency vibration (LMHFV) was shown to significantly enhance osteoporotic fracture healing through alteration of osteocyte lacuno-canalicular ...

    Predicting demographics from meibography using deep learning

    Publication Type: Academic Journal

    Source(s): Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)

    Abstract: Abstract This study introduces a deep learning approach to predicting demographic features from meibography images. A total of 689 meibography images with corresponding subject demographic data were used to develop a deep learning model for predicting ...

    Subjects:

    Ginsenoside Rb1 Alleviates Bleomycin-Induced Pulmonary Inflammation and Fibrosis by Suppressing Central Nucleotide-Binding Oligomerization-, Leucine-Rich Repeat-, and Pyrin Domains-Containing Protein Three Inflammasome Activation and the NF-κB Pathway

    Publication Type: Academic Journal

    Source(s): Drug Design, Development and Therapy, Vol Volume 16, Pp 1793-1809 (2022)

    Authors:

    Abstract: Jingjing Liu,1– 3 Guoqing Fan,1– 3 Ningning Tao,4 Feifei Feng,5 Chao Meng,1– 3 Tieying Sun1,2 1Department of Respiratory Medicine and Critical Care, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Chinese Academy of M...

    Antitumor Immunity from Abdominal Flap-Embedded Therapeutic Cancer Vaccine

    Publication Type: Academic Journal

    Source(s): International Journal of Nanomedicine, Vol Volume 17, Pp 203-212 (2022)

    Authors:

    Abstract: Xiaoling Liu,1,2,* Junhua Mai,1,* Chaoyang Meng,1 Aldona J Spiegel,3 Wei Wei,2 Haifa Shen1 1Department of Nanomedicine, Houston Methodist Academic Institute, Houston, TX, 77030, USA; 2Department of Breast and Thyroid Surgery, Peking University ...

    Ocular surface cooling rate associated with tear film characteristics and the maximum interblink period

    Publication Type: Academic Journal

    Source(s): Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)

    Abstract: Abstract The surface of the human eye is covered with a protective tear film that refreshes with each blink. Natural blinking occurs involuntarily, but one can also voluntarily blink or refrain from blinking. The maximum time one can refrain from blink...

    Subjects:

    Discovery of a potent BTK and IKZF1/3 triple degrader through reversible covalent BTK PROTAC development

    Publication Type: Academic Journal

    Source(s): Current Research in Chemical Biology, Vol 2, Iss , Pp 100029- (2022)

    Abstract: Building on our previous work on ibrutinib-based reversible covalent Bruton's tyrosine kinase (BTK) PROTACs, we explored a different irreversible BTK inhibitor poseltinib as the BTK binder for PROTAC development. Different from ibrutinib, converting th...

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