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Advanced Search Results For "Michaels, Daniel"

1 - 10 of 9,962 results for
 "Michaels, Daniel"
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DNA methylation-based classification of sinonasal tumors

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

Abstract: Sinonasal tumour diagnosis can be complicated by the heterogeneity of disease and classification systems. Here, the authors use machine learning to classify sinonasal undifferentiated carcinomas into 4 molecular classe with differences in differentiati...

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Overall survival and toxicity of Y90 radioembolization for hepatocellular carcinoma patients in Barcelona Clinic Liver Cancer stage C (BCLC-C)

Publication Type: Academic Journal

Source(s): BMC Gastroenterology, Vol 22, Iss 1, Pp 1-10 (2022)

Abstract: Abstract Introduction National Comprehensive Cancer Network HCC guidelines recommend Y90 to treat BCLC-C patients only in select cases given the development of systemic regimens. We sought to identify ideal candidates for Y90 by assessing survival and ...

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Host biology, ecology and the environment influence microbial biomass and diversity in 101 marine fish species

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)

Abstract: In this study, the microbiota of multiple body sites from 101 marine fish species from Southern California were sampled and analysed. The authors compared diversity measures while also establishing a method to estimate microbial biomass. Body site is s...

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Pre-clinical investigation of astatine-211-parthanatine for high-risk neuroblastoma

Publication Type: Academic Journal

Source(s): Communications Biology, Vol 5, Iss 1, Pp 1-9 (2022)

Abstract: The efficacy and toxicity of the PARP inhibitor parthanatine, radiolabeled with the alpha particle emitter astatine-211, in 11 patient derived neuroblastoma murine xenografts is investigated.

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A genome-wide association study with tissue transcriptomics identifies genetic drivers for classic bladder exstrophy

Publication Type: Academic Journal

Source(s): Communications Biology, Vol 5, Iss 1, Pp 1-11 (2022)

Abstract: A genome-wide association study on classic bladder exstrophy reveals eight genome-wide significant loci, most of which contained genes expressed in embryonic developmental bladder stages.

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Impact of random outliers in auto-segmented targets on radiotherapy treatment plans for glioblastoma

Publication Type: Academic Journal

Source(s): Radiation Oncology, Vol 17, Iss 1, Pp 1-18 (2022)

Abstract: Abstract Aims To save time and have more consistent contours, fully automatic segmentation of targets and organs at risk (OAR) is a valuable asset in radiotherapy. Though current deep learning (DL) based models are on par with manual contouring, they a...

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Limited clinical utility for GWAS or polygenic risk score for postoperative acute kidney injury in non-cardiac surgery in European-ancestry patients

Publication Type: Academic Journal

Source(s): BMC Nephrology, Vol 23, Iss 1, Pp 1-11 (2022)

Abstract: Abstract Background Prior studies support a genetic basis for postoperative acute kidney injury (AKI). We conducted a genome-wide association study (GWAS), assessed the clinical utility of a polygenic risk score (PRS), and estimated the heritable compo...

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Clinical Factors Associated with Long-Term Survival in Metastatic Melanoma Treated with Anti-PD1 Alone or in Combination with Ipilimumab

Publication Type: Academic Journal

Source(s): Current Oncology, Vol 29, Iss 608, Pp 7695-7704 (2022)

Abstract: Immune checkpoint inhibitors (ICIs) for treatment of metastatic melanoma (MM) offer lasting overall survival (OS) benefit in a subset of patients. However, outcomes remain poor for non-responders. Clinical predictors of long-term survival remain elusiv...

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Whole genome sequence analysis of blood lipid levels in >66,000 individuals

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

Abstract: Although the common genetic variants contributing to blood lipid levels have been studied, the contribution of rare variants is less understood. Here, the authors perform a rare coding and noncoding variant association study of blood lipid levels using...

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Loss of E-cadherin is causal to pathologic changes in chronic lung disease

Publication Type: Academic Journal

Source(s): Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)

Abstract: Specific loss of the adherens junction protein E-cadherin in alveolar epithelial and airway ciliated cells causes chronic lung disease.

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