Advanced Search Results For "Middelberg, A. P. J."
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Chimeric Virus-Like Particles and Capsomeres Induce Similar CD8+ T Cell Responses but Differ in Capacity to Induce CD4+ T Cell Responses and Antibody Responses
Publication Type: Academic Journal
Source(s): Frontiers in Immunology, Vol 11 (2020)
Abstract: Despite extensive research, the development of an effective malaria vaccine remains elusive. The induction of robust and sustained T cell and antibody response by vaccination is an urgent unmet need. Chimeric virus-like particles (VLPs) are a promising...
Cost-effective downstream processing of recombinantly produced pexiganan peptide and its antimicrobial activity
Publication Type: Academic Journal
Source(s): AMB Express, Vol 8, Iss 1, Pp 1-14 (2018)
Abstract: Abstract Antimicrobial peptides (AMPs) have significant potential as alternatives to classical antibiotics. However, AMPs are currently prepared using processes which are often laborious, expensive and of low-yield, thus hindering their research and ap...
Chimeric Murine Polyomavirus Virus-Like Particles Induce Plasmodium Antigen-Specific CD8+ T Cell and Antibody Responses
Publication Type: Academic Journal
Source(s): Frontiers in Cellular and Infection Microbiology, Vol 9 (2019)
Abstract: An effective vaccine against the Plasmodium parasite is likely to require the induction of robust antibody and T cell responses. Chimeric virus-like particles are an effective vaccine platform for induction of antibody responses, but their capacity to ...
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 8, Iss 1, Pp 1-19 (2017)
Abstract: Genome-wide association studies (GWAS) have become a key tool to discover genetic markers for complex traits; however, environmental factors that interact with genes are rarely considered. Here, the authors conduct a GWAS of obesity traits, and find th...
Assessing the relative appropriateness of the credit management policies of South African universities of technology
Publication Type: Academic Journal
Source(s): Journal of Economic and Financial Sciences, Vol 12, Iss 1, Pp e1-e11 (2019)
Abstract: Orientation: The study explores credit management on the South African higher education landscape in the context of the institutional theory. Research purpose: To calculate a best practice frontier to assess the extent to which universities’ credit ma...
An integrated and continuous downstream process for microbial virus‐like particle vaccine biomanufacture.
Publication Type: Academic Journal
Source(s): Biotechnology & Bioengineering; Aug2022, Vol. 119 Issue 8, p2122-2133, 12p
Abstract: Copyright of Biotechnology & Bioengineering is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may ...
Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 7, Iss 1, Pp 1-19 (2016)
Abstract: Reduced glomerular filtration rate (eGFR) is a hallmark of chronic kidney disease. Here, Pattaro et al. conduct a meta-analysis to discover several new loci associated with variation in eGFR and find that genes associated with eGFR loci often encode pr...
Immunogenicity of Outer Membrane Proteins VirB9-1 and VirB9-2, a Novel Nanovaccine against Anaplasma marginale.
Publication Type: Academic Journal
Source(s): PLoS ONE, Vol 11, Iss 4, p e0154295 (2016)
Abstract: Anaplasma marginale is the most prevalent tick-borne livestock pathogen and poses a significant threat to cattle industry. In contrast to currently available live blood-derived vaccines against A. marginale, alternative safer and better-defined subunit...
Non-carrier nanoparticles adjuvant modular protein vaccine in a particle-dependent manner.
Publication Type: Academic Journal
Source(s): PLoS ONE, Vol 10, Iss 3, p e0117203 (2015)
Abstract: Nanoparticles are increasingly used to adjuvant vaccine formulations due to their biocompatibility, ease of manufacture and the opportunity to tailor their size, shape, and physicochemical properties. The efficacy of similarly-sized silica (Si-OH), pol...
Energetic changes caused by antigenic module insertion in a virus-like particle revealed by experiment and molecular dynamics simulations.
Publication Type: Academic Journal
Source(s): PLoS ONE, Vol 9, Iss 9, p e107313 (2014)
Abstract: The success of recombinant virus-like particles (VLPs) for human papillomavirus and hepatitis B demonstrates the potential of VLPs as safe and efficacious vaccines. With new modular designs emerging, the effects of antigen module insertion on the self-...