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Sequential roles for red blood cell binding proteins enable phased commitment to invasion for malaria parasites
Publication Type: Academic Journal
Source(s): Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract: Abstract Invasion of red blood cells (RBCs) by Plasmodium merozoites is critical to their continued survival within the host. Two major protein families, the Duffy binding-like proteins (DBPs/EBAs) and the reticulocyte binding like proteins (RBLs/RHs) ...
Comparison between regular additional endobiliary radiofrequency ablation and photodynamic therapy in patients with advanced extrahepatic cholangiocarcinoma under systemic chemotherapy
Publication Type: Academic Journal
Source(s): Frontiers in Oncology, Vol 13 (2023)
Abstract: Background and aimsExtrahepatic cholangiocarcinoma (eCCA) remains a malignancy with a dismal prognosis. The first-line standard of care includes systemic chemotherapy (SC) and biliary drainage through stenting. Endobiliary ablative techniques, such as ...
National and subnational short-term forecasting of COVID-19 in Germany and Poland during early 2021
Publication Type: Academic Journal
Source(s): Communications Medicine, Vol 2, Iss 1, Pp 1-17 (2022)
Abstract: Bracher et al. compare 15 forecasting models of COVID-19 cases and deaths in Germany and Poland between January and mid-April 2021. Many, though not all, models outperform a simple baseline model up to four weeks ahead, with ensemble methods showing ve...
Impact of regular additional endobiliary radiofrequency ablation on survival of patients with advanced extrahepatic cholangiocarcinoma under systemic chemotherapy
Publication Type: Academic Journal
Source(s): Scientific Reports, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract: Abstract Prognosis of patients with advanced extrahepatic cholangiocarcinoma (eCCA) is poor. The current standard first-line treatment is systemic chemotherapy (CT) with gemcitabine and a platinum derivate. Additionally, endobiliary radiofrequency abla...
Cation ATPase (ATP4) Orthologue Replacement in the Malaria Parasite Plasmodium knowlesi Reveals Species-Specific Responses to ATP4-Targeting Drugs
Publication Type: Academic Journal
Source(s): mBio, Vol 13, Iss 5 (2022)
Abstract: ABSTRACT Several unrelated classes of antimalarial compounds developed against Plasmodium falciparum target a parasite-specific P-type ATP-dependent Na+ pump, PfATP4. We have previously shown that other malaria parasite species infecting humans are les...
First Line and Second Line Chemotherapy in Advanced Cholangiocarcinoma and Impact of Dose Reduction of Chemotherapy: A Retrospective Analysis
Publication Type: Academic Journal
Source(s): Frontiers in Oncology, Vol 11 (2021)
Abstract: ObjectivePrognosis of patients with irresectable cholangiocarcinoma is still poor. The ABC-02 trial established the current first line (1L) standard systemic chemotherapy (CT) with gemcitabine/platinum derivate for advanced cholangiocarcinoma. However,...
The Plasmodium falciparum Artemisinin Susceptibility-Associated AP-2 Adaptin μ Subunit is Clathrin Independent and Essential for Schizont Maturation
Publication Type: Academic Journal
Source(s): mBio, Vol 11, Iss 1 (2020)
Abstract: ABSTRACT The efficacy of current antimalarial drugs is threatened by reduced susceptibility of Plasmodium falciparum to artemisinin, associated with mutations in pfkelch13. Another gene with variants known to modulate the response to artemisinin encode...
Rapid and iterative genome editing in the malaria parasite Plasmodium knowlesi provides new tools for P. vivax research
Publication Type: Academic Journal
Source(s): eLife, Vol 8 (2019)
Abstract: Tackling relapsing Plasmodium vivax and zoonotic Plasmodium knowlesi infections is critical to reducing malaria incidence and mortality worldwide. Understanding the biology of these important and related parasites was previously constrained by the lack...
Divergent roles for the RH5 complex components, CyRPA and RIPR in human-infective malaria parasites.
Publication Type: Academic Journal
Source(s): PLoS Pathogens, Vol 15, Iss 6, p e1007809 (2019)
Abstract: Malaria is caused by Plasmodium parasites, which invade and replicate in erythrocytes. For Plasmodium falciparum, the major cause of severe malaria in humans, a heterotrimeric complex comprised of the secreted parasite proteins, PfCyRPA, PfRIPR and PfR...
Environmental influences on kelp performance across the reproductive period: an ecological trade-off between gametophyte survival and growth?
Publication Type: Academic Journal
Source(s): PLoS ONE, Vol 8, Iss 6, p e65310 (2013)
Abstract: Most kelps (order Laminariales) exhibit distinct temporal patterns in zoospore production, gametogenesis and gametophyte reproduction. Natural fluctuations in ambient environmental conditions influence the intrinsic characteristics of gametes, which de...