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Advanced Search Results For "Moore, Philip J."

1 - 10 of 2,103 results for
 "Moore, Philip J."
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Novel digital approaches to the assessment of problematic opioid use

Publication Type: Academic Journal

Source(s): BioData Mining, Vol 15, Iss 1, Pp 1-16 (2022)

Abstract: Abstract The opioid epidemic continues to contribute to loss of life through overdose and significant social and economic burdens. Many individuals who develop problematic opioid use (POU) do so after being exposed to prescribed opioid analgesics. Ther...

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Interplay of diverse adjuvants and nanoparticle presentation of native-like HIV-1 envelope trimers

Publication Type: Academic Journal

Source(s): npj Vaccines, Vol 6, Iss 1, Pp 1-8 (2021)

Abstract: Abstract The immunogenicity of HIV-1 envelope (Env) trimers is generally poor. We used the clinically relevant ConM SOSIP trimer to compare the ability of different adjuvants (squalene emulsion, ISCOMATRIX, GLA-LSQ, and MPLA liposomes) to support neutr...

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Rapid community point-of-care testing for COVID-19 (RAPTOR-C19): protocol for a platform diagnostic study

Publication Type: Academic Journal

Source(s): Diagnostic and Prognostic Research, Vol 5, Iss 1, Pp 1-13 (2021)

Abstract: Abstract Background The aim of RApid community Point-of-care Testing fOR COVID-19 (RAPTOR-C19) is to assess the diagnostic accuracy of multiple current and emerging point-of-care tests (POCTs) for active and past SARS-CoV2 infection in the community se...

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Immunofocusing and enhancing autologous Tier-2 HIV-1 neutralization by displaying Env trimers on two-component protein nanoparticles

Publication Type: Academic Journal

Source(s): npj Vaccines, Vol 6, Iss 1, Pp 1-14 (2021)

Abstract: Abstract The HIV-1 envelope glycoprotein trimer is poorly immunogenic because it is covered by a dense glycan shield. As a result, recombinant Env glycoproteins generally elicit inadequate antibody levels that neutralize clinically relevant, neutraliza...

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LAT1 and SNAT2 Protein Expression and Membrane Localization of LAT1 Are Not Acutely Altered by Dietary Amino Acids or Resistance Exercise Nor Positively Associated with Leucine or Phenylalanine Incorporation in Human Skeletal Muscle

Publication Type: Academic Journal

Source(s): Nutrients, Vol 13, Iss 3906, p 3906 (2021)

Abstract: The influx of essential amino acids into skeletal muscle is primarily mediated by the large neutral amino acid transporter 1 (LAT1), which is dependent on the glutamine gradient generated by the sodium-dependent neutral amino acid transporter 2 (SNAT2)...

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Multilevel mobile health approach to improve cardiovascular health in resource-limited communities with Step It Up: a randomised controlled trial protocol targeting physical activity

Publication Type: Academic Journal

Source(s): BMJ Open, Vol 10, Iss 12 (2020)

Abstract: Introduction Although physical activity (PA) reduces cardiovascular disease (CVD) risk, physical inactivity remains a pressing public health concern, especially among African American (AA) women in the USA. PA interventions focused on AA women living i...

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Distinct Immunoglobulin Fc Glycosylation Patterns Are Associated with Disease Nonprogression and Broadly Neutralizing Antibody Responses in Children with HIV Infection

Publication Type: Academic Journal

Source(s): mSphere, Vol 5, Iss 6 (2020)

Abstract: ABSTRACT A prophylactic HIV vaccine would ideally induce protective immunity prior to sexual debut. Children develop broadly neutralizing antibody (bnAb) responses faster and at higher frequencies than adults, but little is known about the underlying m...

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Enhancing and shaping the immunogenicity of native-like HIV-1 envelope trimers with a two-component protein nanoparticle

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)

Abstract: Nanoparticles are a promising approach to increase immunogenicity of protein antigens for vaccines. Here, Brouwer et al. design self-assembling, two-component protein NPs that present native-like SOSIP trimers of HIV envelope protein and determine immu...

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Structural and functional evaluation of de novo-designed, two-component nanoparticle carriers for HIV Env trimer immunogens.

Publication Type: Academic Journal

Source(s): PLoS Pathogens, Vol 16, Iss 8, p e1008665 (2020)

Abstract: Two-component, self-assembling nanoparticles represent a versatile platform for multivalent presentation of viral antigens. Computational design of protein nanoparticles with differing sizes and geometries enables combination with antigens of choice to...

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