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Advanced Search Results For "Nickel, Miriam"

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 "Nickel, Miriam"
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3D-printed SAXS chamber for controlled in situ dialysis and optical characterization

Publication Type:Academic Journal

Source(s):Journal of Synchrotron Radiation, Vol 29, Iss 4, Pp 1014-1019 (2022)

Abstract:3D printing changes the scope of how samples can be mounted for small-angle X-ray scattering (SAXS). In this paper a 3D-printed X-ray chamber, which allows for in situ exchange of buffer and in situ optical transmission spectroscopy, is presented. The ...

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Case Report: Possible autoimmune obsessive-compulsive disorder with postpartum onset

Publication Type:Academic Journal

Source(s):Frontiers in Immunology, Vol 13 (2022)

Abstract:Autoimmune obsessive–compulsive disorder (OCD) is rare. The case presented here is that of a female patient in her mid-thirties who developed postpartum OCD. Magnetic resonance imaging showed multiple juxtacortical hyperintensities that may have been p...

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Biomechanics in ascending aortic aneurysms correlate with tissue composition and strengthCentral MessagePerspective

Publication Type:Academic Journal

Source(s):JTCVS Open, Vol 9, Iss , Pp 1-10 (2022)

Abstract:Objective: This study correlates low strain tangential modulus (LTM) and transition zone onset (TZo) stress, biomechanical parameters that occur within the physiological range of stress seen in vivo, with tissue strength and histopathologic changes in ...

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Immunological causes of obsessive-compulsive disorder: is it time for the concept of an “autoimmune OCD” subtype?

Publication Type:Academic Journal

Source(s):Translational Psychiatry, Vol 12, Iss 1, Pp 1-14 (2022)

Abstract:Abstract Obsessive-compulsive disorder (OCD) is a highly disabling mental illness that can be divided into frequent primary and rarer organic secondary forms. Its association with secondary autoimmune triggers was introduced through the discovery of Pe...

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Natural History Studies in NCL and Their Expanding Role in Drug Development: Experiences From CLN2 Disease and Relevance for Clinical Trials

Publication Type:Academic Journal

Source(s):Frontiers in Neurology, Vol 13 (2022)

Abstract:Conducting clinical trials in rare diseases is challenging. In trials that aim to use natural history control cohorts for evaluation of efficacy, lack of data on natural history of disease prolongs development of future therapies significantly. Therefo...

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Investigating health-related quality of life in rare diseases: a case study in utility value determination for patients with CLN2 disease (neuronal ceroid lipofuscinosis type 2)

Publication Type:Academic Journal

Source(s):Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-13 (2021)

Abstract:Abstract Background Utility studies enable preference-based quantification of a disease’s impact on patients’ health-related quality of life (HRQoL). It is often difficult to obtain utility values for rare, neurodegenerative conditions due to cognitive...

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Increased GFAP concentrations in the cerebrospinal fluid of patients with unipolar depression

Publication Type:Academic Journal

Source(s):Translational Psychiatry, Vol 11, Iss 1, Pp 1-9 (2021)

Abstract:Abstract Inflammatory processes involving altered microglial activity may play a relevant role in the pathophysiology of depressive disorders. Glial fibrillary acidic protein (GFAP) and calcium-binding protein S100B are considered microglial markers. T...

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Guidelines on the diagnosis, clinical assessments, treatment and management for CLN2 disease patients

Publication Type:Academic Journal

Source(s):Orphanet Journal of Rare Diseases, Vol 16, Iss 1, Pp 1-19 (2021)

Abstract:Abstract Background CLN2 disease (Neuronal Ceroid Lipofuscinosis Type 2) is an ultra-rare, neurodegenerative lysosomal storage disease, caused by an enzyme deficiency of tripeptidyl peptidase 1 (TPP1). Lack of disease awareness and the non-specificity ...

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Genetic Ablation of the Mitochondrial Calcium Uniporter (MCU) Does not Impair T Cell-Mediated Immunity In Vivo

Publication Type:Academic Journal

Source(s):Frontiers in Pharmacology, Vol 12 (2021)

Abstract:T cell activation and differentiation is associated with metabolic reprogramming to cope with the increased bioenergetic demand and to provide metabolic intermediates for the biosynthesis of building blocks. Antigen receptor stimulation not only promot...

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Sex difference in cerebrospinal fluid/blood albumin quotients in patients with schizophreniform and affective psychosis

Publication Type:Academic Journal

Source(s):Fluids and Barriers of the CNS, Vol 17, Iss 1, Pp 1-12 (2020)

Abstract:Abstract Background The importance of cerebrospinal fluid (CSF) diagnostics for psychiatry is growing. The CSF/blood albumin quotient (QAlb) is considered to be a measure of the blood–CSF barrier function. Recently, systematically higher QAlb in males ...

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