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TGFβ2 Induces the Soluble Isoform of CTLA-4 – Implications for CTLA-4 Based Checkpoint Inhibitor Antibodies in Malignant Melanoma
Publication Type: Academic Journal
Source(s): Frontiers in Immunology, Vol 12 (2022)
Abstract: Malignant melanoma is an aggressive form of cancer, which can be treated with anti-CTLA-4 and anti-PD-1 checkpoint inhibitor antibodies but while anti-CTLA-4 antibodies have clear benefits for some patients with melanoma, productive responses are diffi...
Assessment of thrombotic risk during long-term treatment of immune thrombocytopenia with fostamatinib
Publication Type: Academic Journal
Source(s): Therapeutic Advances in Hematology, Vol 12 (2021)
Abstract: Background: Patients with immune thrombocytopenia (ITP) are at risk of bleeding and, paradoxically, thromboembolic events (TEEs), irrespective of thrombocytopenia. The risk of thrombosis is increased by advanced age, obesity, and prothrombotic comorbid...
Feasibility of reporting results of large randomised controlled trials to participants: experience from the Fluoxetine Or Control Under Supervision (FOCUS) trial
Publication Type: Academic Journal
Source(s): BMJ Open, Vol 10, Iss 11 (2020)
Abstract: Objectives Informing research participants of the results of studies in which they took part is viewed as an ethical imperative. However, there is little guidance in the literature about how to do this. The Fluoxetine Or Control Under Supervision trial...
Crystal structure, Hirshfeld surface analysis and PIXEL calculations of a 1:1 epimeric mixture of 3-[(4-nitrobenzylidene)amino]-2(R,S)-(4-nitrophenyl)-5(S)-(propan-2-yl)imidazolidin-4-one
Publication Type: Academic Journal
Source(s): Acta Crystallographica Section E: Crystallographic Communications, Vol 75, Iss 11, Pp 1774-1782 (2019)
Abstract: A 1:1 epimeric mixture of 3-[(4-nitrobenzylidene)amino]-2(R,S)-(4-nitrophenyl)-5(S)-(propan-2-yl)imidazolidin-4-one, C19H19N5O5, was isolated from a reaction mixture of 2(S)-amino-3-methyl-1-oxobutanehydrazine and 4-nitrobenzaldehyde in ethanol. The pr...
Crystal structures and Hirshfeld surface analyses of (E)-N′-benzylidene-2-oxo-2H-chromene-3-carbohydrazide and the disordered hemi-DMSO solvate of (E)-2-oxo-N′-(3,4,5-trimethoxybenzylidene)-2H-chromene-3-carbohydrazide: lattice energy and intermolecular interaction energy calculations for the former
Publication Type: Academic Journal
Source(s): Acta Crystallographica Section E: Crystallographic Communications, Vol 75, Iss 10, Pp 1403-1410 (2019)
Abstract: The crystal structures of the disordered hemi-DMSO solvate of (E)-2-oxo-N′-(3,4,5-trimethoxybenzylidene)-2H-chromene-3-carbohydrazide, C20H18N2O6·0.5C2H6OS, and (E)-N′-benzylidene-2-oxo-2H-chromene-3-carbohydrazide, C17H12N2O3 (4: R = C6H5), are discus...
Risk assessments and structured care interventions for prevention of foot ulceration in diabetes: development and validation of a prognostic model
Publication Type: Academic Journal
Source(s): Health Technology Assessment, Vol 24, Iss 62 (2020)
Abstract: Background: Diabetes-related foot ulcers give rise to considerable morbidity, generate a high monetary cost for health and social care services and precede the majority of diabetes-related lower extremity amputations. There are many clinical prediction...
Decreasing Interstage Mortality After the Norwood Procedure: A 30‐Year Experience
Publication Type: Academic Journal
Source(s): Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 9, Iss 19 (2020)
Abstract: Background The superior cavo‐pulmonary connection was introduced at our institution in 1988 for infants undergoing surgery for hypoplastic left heart syndrome. Patients with hypoplastic left heart syndrome remain at high risk for mortality in the time ...
Crystal structures and Hirshfeld surfaces of four methoxybenzaldehyde oxime derivatives, 2-MeO-XC6H3C=NOH (X = H and 2-, 3- and 4-MeO): different conformations and hydrogen-bonding patterns
Publication Type: Academic Journal
Source(s): Acta Crystallographica Section E: Crystallographic Communications, Vol 74, Iss 11, Pp 1553-1560 (2018)
Abstract: The crystal structures of four (E)-methoxybenzaldehyde oxime derivatives, namely (2-methoxybenzaldehyde oxime, 1, 2,3-dimethoxybenzaldehyde oxime, 2, 4-dimethoxybenzaldehyde oxime, 3, and 2,5-dimethoxybenzaldehyde oxime, 4, are discussed. The arrangeme...
Different classical hydrogen-bonding patterns in three salicylaldoxime derivatives, 2-HO-4-XC6H3C=NOH (X = Me, OH and MeO)
Publication Type: Academic Journal
Source(s): Acta Crystallographica Section E: Crystallographic Communications, Vol 74, Iss 10, Pp 1480-1485 (2018)
Abstract: The crystal structures of three salicyaldoxime compounds, namely 2-hydroxy-4-methylbenzaldehyde oxime, C8H9NO2, 1, 2,4-dihydroxybenzaldehyde oxime, C7H7NO3, 2, and 2-hydroxy-4-methoxybenzaldehyde oxime, C8H9NO3, 3, are discussed. In each compound, the ...
The Ability of a Non-Egg Adapted (Cell-Like) A(H1N1)pdm09 Virus to Egg-Adapt at HA Loci Other than 222 and 223 and Its Effect on the Yield of Viral Protein.
Publication Type: Academic Journal
Source(s): PLoS ONE, Vol 11, Iss 11, p e0166761 (2016)
Abstract: Previous studies on influenza A(H1N1)pdm09 candidate vaccine viruses (CVVs) that had adapted to growth in embryonated chicken eggs by the acquisition of amino acid substitutions at HA positions 222 or 223 showed that improved protein yield could be con...