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Advanced Search Results For "Noah, Timothy"

1 - 10 of 1,406 results for
 "Noah, Timothy"
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Composites of (C4F)n and (CF)n Synthesized by Uncatalyzed Fluorination of Graphite

Publication Type:Academic Journal

Source(s):Solids, Vol 3, Iss 17, Pp 237-257 (2022)

Abstract:A new solid-state 19F magic-angle spinning NMR signal at an isotropic 19F chemical shift of −53 ppm is measured from graphite fluoride synthesized by reaction of graphite with F2 at temperatures above 750 K with no catalyst. Two-dimensional NMR suggest...

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PPM1D mutations are oncogenic drivers of de novo diffuse midline glioma formation

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

Abstract:PPM1D is a known mediator of p53 signalling, and has been linked to treatment resistance in glioma. In this work, the authors utilise genomics, proteomics, and mouse models to determine the role of PPM1D in the development of diffuse midline glioma.

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Miller’s Mayhem.

Publication Type:Periodical

Source(s):New Republic; Oct2022, Vol. 253 Issue 10, p4-6, 3p, 1 Illustration

Abstract:The article presents the author's views on the AFL (America First Legal). It highlights that AFL is a nonprofit law firm formed by Stephen Miller, former senior policy adviser in the Trump Administration; Gene Hamilton, a former official from Trump's H...

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Determinants of penetrance and variable expressivity in monogenic metabolic conditions across 77,184 exomes

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Abstract:Penetrance of variants in monogenic disease and clinical utility of common polygenic variation has not been well explored on a large-scale. Here, the authors use exome sequencing data from 77,184 individuals to generate penetrance estimates and assess ...

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FOXA1 and adaptive response determinants to HER2 targeted therapy in TBCRC 036

Publication Type:Academic Journal

Source(s):npj Breast Cancer, Vol 7, Iss 1, Pp 1-15 (2021)

Abstract:Abstract Inhibition of the HER2/ERBB2 receptor is a keystone to treating HER2-positive malignancies, particularly breast cancer, but a significant fraction of HER2-positive (HER2+) breast cancers recur or fail to respond. Anti-HER2 monoclonal antibodie...

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An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients

Publication Type:Academic Journal

Source(s):iScience, Vol 24, Iss 11, Pp 103221- (2021)

Abstract:Summary: Neurodegenerative diseases are challenging for systems biology because of the lack of reliable animal models or patient samples at early disease stages. Induced pluripotent stem cells (iPSCs) could address these challenges. We investigated DNA...

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The Effects of Carbohydrate versus Fat Restriction on Lipid Profiles in Highly Trained, Recreational Distance Runners: A Randomized, Cross-Over Trial

Publication Type:Academic Journal

Source(s):Nutrients, Vol 14, Iss 1135, p 1135 (2022)

Abstract:A growing number of endurance athletes have considered switching from a traditional high-carbohydrate/low-fat (HCLF) to a low-carbohydrate/high-fat (LCHF) eating pattern for health and performance reasons. However, few studies have examined how LCHF di...

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Brain White Matter Structure and Amyloid Deposition in Black and White Older Adults: The ARIC‐PET Study

Publication Type:Academic Journal

Source(s):Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 10, Iss 17 (2021)

Abstract:Background White matter abnormalities are a common feature of aging and Alzheimer disease, and tend to be more severe among Black individuals. However, the extent to which white matter abnormalities relate to amyloid deposition, a marker of Alzheimer p...

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Innate Immune System Activation and Neuroinflammation in Down Syndrome and Neurodegeneration: Therapeutic Targets or Partners?

Publication Type:Academic Journal

Source(s):Frontiers in Aging Neuroscience, Vol 13 (2021)

Abstract:Innate immune system activation and inflammation are associated with and may contribute to clinical outcomes in people with Down syndrome (DS), neurodegenerative diseases such as Alzheimer’s disease (AD), and normal aging. In addition to serving as pot...

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Contrasting effects of Western vs Mediterranean diets on monocyte inflammatory gene expression and social behavior in a primate model

Publication Type:Academic Journal

Source(s):eLife, Vol 10 (2021)

Abstract:Dietary changes associated with industrialization increase the prevalence of chronic diseases, such as obesity, type II diabetes, and cardiovascular disease. This relationship is often attributed to an ‘evolutionary mismatch’ between human physiology a...

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