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Anti–PD-L1 and anti-CD73 combination therapy promotes T cell response to EGFR-mutated NSCLC
Publication Type: Academic Journal
Source(s): JCI Insight, Vol 7, Iss 3 (2022)
Abstract: Treatment with anti–PD-1 and anti-PD-L1 therapies has shown durable clinical benefit in non–small cell lung cancer (NSCLC). However, patients with NSCLC with epidermal growth factor receptor (EGFR) mutations do not respond as well to treatment as patie...
Structure-guided selection of puromycin N-acetyltransferase mutants with enhanced selection stringency for deriving mammalian cell lines expressing recombinant proteins
Publication Type: Academic Journal
Source(s): Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract: Abstract Puromycin and the Streptomyces alboniger-derived puromycin N-acetyltransferase (PAC) enzyme form a commonly used system for selecting stably transfected cultured cells. The crystal structure of PAC has been solved using X-ray crystallography, ...
Open data from the first and second observing runs of Advanced LIGO and Advanced Virgo
Publication Type: Academic Journal
Source(s): SoftwareX, Vol 13, Iss , Pp 100658- (2021)
Abstract: Advanced LIGO and Advanced Virgo are monitoring the sky and collecting gravitational-wave strain data with sufficient sensitivity to detect signals routinely. In this paper we describe the data recorded by these instruments during their first and secon...
A randomised controlled trial and cost-consequence analysis of traditional and digital foot orthoses supply chains in a National Health Service setting: application to feet at risk of diabetic plantar ulceration
Publication Type: Academic Journal
Source(s): Journal of Foot and Ankle Research, Vol 12, Iss 1, Pp 1-13 (2019)
Abstract: Abstract Background Diabetic foot ulceration is a considerable cost to the NHS and foot orthotic provision is a core strategy for the management of the people with diabetes and a moderate to high risk of foot ulceration. The traditional process to prod...
Real-world experience of ibrutinib therapy in relapsed chronic lymphocytic leukemia: results of a single-center retrospective analysis
Publication Type: Academic Journal
Source(s): Journal of Blood Medicine, Vol Volume 10, Pp 199-208 (2019)
Abstract: Elisabeth Nuttall,1,2 Joanna Tung,3 Ellie Trounce,3 Rosalynd Johnston,2 Timothy Chevassut2,31Nelson Hospital, Nelson and Marlborough District Health Board, Nelson, New Zealand; 2Department of Haematology, Royal Sussex County Hospital, Brighton and Suss...
Prospects for observing and localizing gravitational-wave transients with Advanced LIGO, Advanced Virgo and KAGRA
Publication Type: Academic Journal
Source(s): Living Reviews in Relativity, Vol 21, Iss 1, Pp 1-57 (2018)
Abstract: Abstract We present possible observing scenarios for the Advanced LIGO, Advanced Virgo and KAGRA gravitational-wave detectors over the next decade, with the intention of providing information to the astronomy community to facilitate planning for multi-...
Motor Imagery of Speech: The Involvement of Primary Motor Cortex in Manual and Articulatory Motor Imagery
Publication Type: Academic Journal
Source(s): Frontiers in Human Neuroscience, Vol 13 (2019)
Abstract: Motor imagery refers to the phenomenon of imagining performing an action without action execution. Motor imagery and motor execution are assumed to share a similar underlying neural system that involves primary motor cortex (M1). Previous studies have ...
Guidelines for the vaccination of HIV-infected adolescents and adults in South Africa
Publication Type: Academic Journal
Source(s): Southern African Journal of HIV Medicine, Vol 19, Iss 1, Pp e1-e8 (2018)
Abstract: No abstract available.
GWTC-1: A Gravitational-Wave Transient Catalog of Compact Binary Mergers Observed by LIGO and Virgo during the First and Second Observing Runs
Publication Type: Academic Journal
Source(s): Physical Review X, Vol 9, Iss 3, p 031040 (2019)
Abstract: We present the results from three gravitational-wave searches for coalescing compact binaries with component masses above 1 M_{⊙} during the first and second observing runs of the advanced gravitational-wave detector network. During the first observing...
Properties of the Binary Neutron Star Merger GW170817
Publication Type: Academic Journal
Source(s): Physical Review X, Vol 9, Iss 1, p 011001 (2019)
Abstract: On August 17, 2017, the Advanced LIGO and Advanced Virgo gravitational-wave detectors observed a low-mass compact binary inspiral. The initial sky localization of the source of the gravitational-wave signal, GW170817, allowed electromagnetic observator...