Advanced Search Results For "O'Brien, Timothy L."
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Scientific Disciplines and the Admissibility of Expert Evidence in Courts
Publication Type: Academic Journal
Source(s): Socius, Vol 8 (2022)
Abstract: The authors examine how people interpret expert claims when they do not share experts’ technical understanding. The authors review sociological research on the cultural boundaries of science and expertise, which suggests that scientific disciplines are...
Development and application of Diels-Alder adducts displaying AIE properties
Publication Type: Academic Journal
Source(s): Cell Reports Physical Science, Vol 3, Iss 2, Pp 100766- (2022)
Abstract: Summary: Exploring organic reactions to construct novel molecules with aggregation-induced emission (AIE) features is an essential branch of AIE research. The fast-paced application of AIE materials in various disciplines, including photoelectricity, m...
The Microbiological Drivers of Temporally Dynamic Dimethylsulfoniopropionate Cycling Processes in Australian Coastal Shelf Waters
Publication Type: Academic Journal
Source(s): Frontiers in Microbiology, Vol 13 (2022)
Abstract: The organic sulfur compounds dimethylsulfoniopropionate (DMSP) and dimethyl sulfoxide (DMSO) play major roles in the marine microbial food web and have substantial climatic importance as sources and sinks of dimethyl sulfide (DMS). Seasonal shifts in t...
Neurologic Manifestations of Severe Acute Respiratory Syndrome Coronavirus 2 Infection in Hospitalized Patients During the First Year of the COVID-19 Pandemic
Publication Type: Academic Journal
Source(s): Critical Care Explorations, Vol 4, Iss 4, p e0686 (2022)
Abstract: OBJECTIVES:. To describe the prevalence, associated risk factors, and outcomes of serious neurologic manifestations (encephalopathy, stroke, seizure, and meningitis/encephalitis) among patients hospitalized with severe acute respiratory syndrome corona...
Grand Challenges in global eye health: a global prioritisation process using Delphi method
Publication Type: Academic Journal
Source(s): The Lancet. Healthy Longevity, Vol 3, Iss 1, Pp e31-e41 (2022)
Abstract: Summary: Background: We undertook a Grand Challenges in Global Eye Health prioritisation exercise to identify the key issues that must be addressed to improve eye health in the context of an ageing population, to eliminate persistent inequities in heal...
The impact of viral mutations on recognition by SARS-CoV-2 specific T cells
Publication Type: Academic Journal
Source(s): iScience, Vol 24, Iss 11, Pp 103353- (2021)
Abstract: Summary: We identify amino acid variants within dominant SARS-CoV-2 T cell epitopes by interrogating global sequence data. Several variants within nucleocapsid and ORF3a epitopes have arisen independently in multiple lineages and result in loss of reco...
Uncoupling Molecular Testing for SARS-CoV-2 From International Supply Chains
Publication Type: Academic Journal
Source(s): Frontiers in Public Health, Vol 9 (2022)
Abstract: The rapid global rise of COVID-19 from late 2019 caught major manufacturers of RT-qPCR reagents by surprise and threw into sharp focus the heavy reliance of molecular diagnostic providers on a handful of reagent suppliers. In addition, lockdown and tra...
Variation in Use of Repurposed Medications Among Patients With Coronavirus Disease 2019. From The Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study: Coronavirus Disease 2019 Registry Investigator Group
Publication Type: Academic Journal
Source(s): Critical Care Explorations, Vol 3, Iss 11, p e0566 (2021)
Abstract: IMPORTANCE:. At the start of the coronavirus disease 2019 pandemic, medications repurposed for management of coronavirus disease 2019 were used in the absence of clinical trial evidence. OBJECTIVES:. To describe the variation and evolution in use of re...
Recurrent emergence of SARS-CoV-2 spike deletion H69/V70 and its role in the Alpha variant B.1.1.7
Publication Type: Academic Journal
Source(s): Cell Reports, Vol 35, Iss 13, Pp 109292- (2021)
Abstract: Summary: We report severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike ΔH69/V70 in multiple independent lineages, often occurring after acquisition of receptor binding motif replacements such as N439K and Y453F, known to increase binding...
Ex Vivo Cell Therapy by Ectopic Hepatocyte Transplantation Treats the Porcine Tyrosinemia Model of Acute Liver Failure
Publication Type: Academic Journal
Source(s): Molecular Therapy: Methods & Clinical Development, Vol 18, Iss , Pp 738-750 (2020)
Abstract: The effectiveness of cell-based therapies to treat liver failure is often limited by the diseased liver environment. Here, we provide preclinical proof of concept for hepatocyte transplantation into lymph nodes as a cure for liver failure in a large-an...