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The new Italian registry of infantile thrombosis (RITI): A reflection on its journey, challenges and pitfalls
Publication Type: Academic Journal
Source(s): Frontiers in Pediatrics, Vol 11 (2023)
Abstract: IntroductionThrombotic events in neonates and children represent a rare although severe occurrence in view of the associated risk of mortality and sequelae. Quality evidence is limited in this field, and registry studies provide an essential base for r...
Bifidobacterium affects antitumor efficacy of oncolytic adenovirus in a mouse model of melanoma
Publication Type: Academic Journal
Source(s): iScience, Vol 26, Iss 10, Pp 107668- (2023)
Abstract: Summary: Gut microbiota plays a key role in modulating responses to cancer immunotherapy in melanoma patients. Oncolytic viruses (OVs) represent emerging tools in cancer therapy, inducing a potent immunogenic cancer cell death (ICD) and recruiting immu...
Corrigendum: Immune checkpoint inhibitor therapy increases systemic SDF-1, cardiac DAMPs Fibronectin-EDA, S100/Calgranulin, galectine-3, and NLRP3-MyD88-chemokine pathways
Publication Type: Academic Journal
Source(s): Frontiers in Cardiovascular Medicine, Vol 10 (2023)
Novel tri-specific tribodies induce strong T cell activation and anti-tumor effects in vitro and in vivo
Publication Type: Academic Journal
Source(s): Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-20 (2022)
Abstract: Abstract Background Immunotherapy based on Bi-specific T Cell Engagers (TCE) represents one of the most attractive strategy to treat cancers resistant to conventional therapies. TCE are antibody-like proteins that simultaneously bind with one arm to a ...
Comparative Analysis of a Human Neutralizing mAb Specific for SARS-CoV-2 Spike-RBD with Cilgavimab and Tixagevimab for the Efficacy on the Omicron Variant in Neutralizing and Detection Assays.
Publication Type: Academic Journal
Source(s): International Journal of Molecular Sciences. Jun2023, Vol. 24 Issue 12, p10053. 17p.
Abstract: The recent pandemic years have prompted the scientific community to increasingly search for and adopt new and more efficient therapeutic and diagnostic approaches to deal with a new infection. In addition to the development of vaccines, which has playe...
Comparative Analysis of a Human Neutralizing mAb Specific for SARS-CoV-2 Spike-RBD with Cilgavimab and Tixagevimab for the Efficacy on the Omicron Variant in Neutralizing and Detection Assays
Publication Type: Academic Journal
Source(s): International Journal of Molecular Sciences, Vol 24, Iss 10053, p 10053 (2023)
Abstract: The recent pandemic years have prompted the scientific community to increasingly search for and adopt new and more efficient therapeutic and diagnostic approaches to deal with a new infection. In addition to the development of vaccines, which has playe...
Immune checkpoint inhibitor therapy increases systemic SDF-1, cardiac DAMPs Fibronectin-EDA, S100/Calgranulin, galectine-3, and NLRP3-MyD88-chemokine pathways
Publication Type: Academic Journal
Source(s): Frontiers in Cardiovascular Medicine, Vol 9 (2022)
Abstract: BackgroundImmune checkpoint inhibitors (ICIs) have significantly changed the oncology clinic in recent years, improving survival expectations in cancer patients. ICI therapy have a broad spectrum of side effects from endocrinopathies to cardiovascular ...
Oncolytic Adenoviral Vector-Mediated Expression of an Anti-PD-L1-scFv Improves Anti-Tumoral Efficacy in a Melanoma Mouse Model
Publication Type: Academic Journal
Source(s): Frontiers in Oncology, Vol 12 (2022)
Abstract: Oncolytic virotherapy is an emerging therapeutic approach based on replication-competent viruses able to selectively infect and destroy cancer cells, inducing the release of tumor-associated antigens and thereby recruiting immune cells with a subsequen...
New Insights on the Role of Anti-PD-L1 and Anti-CTLA-4 mAbs on Different Lymphocytes Subpopulations in TNBC
Publication Type: Academic Journal
Source(s): Cancers, Vol 14, Iss 5289, p 5289 (2022)
Abstract: Antibody-based cancer immunotherapy includes monoclonals against immune checkpoints (ICs), to modulate specific T cell responses against cancer. NK cells are a newly emerging target for immune checkpoint receptor inhibition in cancer immunotherapy, as ...
Novel human neutralizing mAbs specific for Spike-RBD of SARS-CoV-2
Publication Type: Academic Journal
Source(s): Scientific Reports, Vol 11, Iss 1, Pp 1-16 (2021)
Abstract: Abstract Among the therapies against the pandemic SARS-CoV-2 virus, monoclonal Antibodies (mAbs) targeting the Spike glycoprotein represent good candidates to interfere in the Spike/ACE2 interaction, preventing virus cell entry. Since anti-spike mAbs, ...