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Advanced Search Results For "Pauls, Jerome"

1 - 10 of 446 results for
 "Pauls, Jerome"
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Genetic analyses of the electrocardiographic QT interval and its components identify additional loci and pathways

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)

Abstract:The QT interval is a heritable electrocardiographic measure associated with arrhythmia risk when prolonged. Here, the authors used a series of genetic analyses to identify genetic loci, pathways, therapeutic targets, and relationships with cardiovascul...

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Low quantity and quality of anti-spike humoral response is linked to CD4 T-cell apoptosis in COVID-19 patients

Publication Type:Academic Journal

Source(s):Cell Death and Disease, Vol 13, Iss 8, Pp 1-15 (2022)

Abstract:Abstract In addition to an inflammatory reaction, Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)-infected patients present lymphopenia, which we recently reported as being related to abnormal programmed cell death. As an efficient humoral...

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Non-linear machine learning models incorporating SNPs and PRS improve polygenic prediction in diverse human populations

Publication Type:Academic Journal

Source(s):Communications Biology, Vol 5, Iss 1, Pp 1-12 (2022)

Abstract:Combining a standard polygenic risk score (PRS) as a feature in a machine learning model increases the percentage variance explained for those traits, helping to account for non-linearities or interaction effects in genetics-based prediction models.

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Childhood encephalitis in the Greater Mekong region (the SouthEast Asia Encephalitis Project): a multicentre prospective study

Publication Type:Academic Journal

Source(s):The Lancet Global Health, Vol 10, Iss 7, Pp e989-e1002 (2022)

Abstract:Summary: Background: Encephalitis is a worldwide public health issue, with a substantially high burden among children in southeast Asia. We aimed to determine the causes of encephalitis in children admitted to hospitals across the Greater Mekong region...

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Differential and shared genetic effects on kidney function between diabetic and non-diabetic individuals

Publication Type:Academic Journal

Source(s):Communications Biology, Vol 5, Iss 1, Pp 1-20 (2022)

Abstract:A large-scale GWAS provides insight on diabetes-dependent genetic effects on the glomerular filtration rate, a common metric to monitor kidney health in disease.

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Effects of hospital facilities on patient outcomes after cancer surgery: an international, prospective, observational study

Publication Type:Academic Journal

Source(s):The Lancet Global Health, Vol 10, Iss 7, Pp e1003-e1011 (2022)

Abstract:Summary: Background: Early death after cancer surgery is higher in low-income and middle-income countries (LMICs) compared with in high-income countries, yet the impact of facility characteristics on early postoperative outcomes is unknown. The aim of ...

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Neuromorphic object localization using resistive memories and ultrasonic transducers

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)

Abstract:The real-world object localization application needs a low-latency and power efficient computing system. Here, Moro et al. demonstrate a neuromorphic in-memory event driven system, inspired by the barn owl’s neuroanatomy, which is orders of magnitude m...

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Origins of glycan selectivity in streptococcal Siglec-like adhesins suggest mechanisms of receptor adaptation

Publication Type:Academic Journal

Source(s):Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

Abstract:Streptococcal siglec-like binding regions (SLBRs) selectively bind cell surface glycans, but the basis for this selectivity is not understood. Here, the authors identify selectivity-modulating SLBR regions and study how changes in SLBR glycan selectivi...

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Multiagent off-screen behavior prediction in football

Publication Type:Academic Journal

Source(s):Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)

Abstract:Abstract In multiagent worlds, several decision-making individuals interact while adhering to the dynamics constraints imposed by the environment. These interactions, combined with the potential stochasticity of the agents’ dynamic behaviors, make such...

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Identifying the Common Genetic Basis of Antidepressant Response

Publication Type:Academic Journal

Source(s):Biological Psychiatry Global Open Science, Vol 2, Iss 2, Pp 115-126 (2022)

Abstract:Background: Antidepressants are a first-line treatment for depression. However, only a third of individuals experience remission after the first treatment. Common genetic variation, in part, likely regulates antidepressant response, yet the success of ...

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