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Advanced Search Results For "Penn-Nicholson A"

1 - 10 of 149 results for
 "Penn-Nicholson A"
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Are mRNA based transcriptomic signatures ready for diagnosing tuberculosis in the clinic? - A review of evidence and the technological landscape

Publication Type: Academic Journal

Source(s): EBioMedicine, Vol 82, Iss , Pp 104174- (2022)

Abstract: Summary: Advances in discovery and validation of diagnostic, prognostic and treatment-monitoring transcriptomic signatures of tuberculosis (TB) disease could accelerate the goal to end TB. We conducted a review to evaluate whether mRNA transcriptomics ...

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Prospective multicentre head-to-head validation of host blood transcriptomic biomarkers for pulmonary tuberculosis by real-time PCR

Publication Type: Academic Journal

Source(s): Communications Medicine, Vol 2, Iss 1, Pp 1-13 (2022)

Abstract: Plain Language Summary Delays in tuberculosis (TB) diagnosis result in increased disease severity, risk of death, and infection of further individuals. The presence of symptoms is typically used to find people with TB. However, about half of individual...

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Evaluation of a transcriptomic signature of tuberculosis risk in combination with an interferon gamma release assay: A diagnostic test accuracy study

Publication Type: Academic Journal

Source(s): EClinicalMedicine, Vol 47, Iss , Pp 101396- (2022)

Abstract: Summary: Background: We evaluated the diagnostic and prognostic performance of a transcriptomic signature of tuberculosis (TB) risk (RISK11) and QuantiFERON-TB Gold-plus (QFTPlus) as combination biomarkers of TB risk. Methods: Healthy South Africans wh...

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The effect of host factors on discriminatory performance of a transcriptomic signature of tuberculosis risk

Publication Type: Academic Journal

Source(s): EBioMedicine, Vol 77, Iss , Pp 103886- (2022)

Abstract: Summary: Background: We aimed to understand host factors that affect discriminatory performance of a transcriptomic signature of tuberculosis risk (RISK11). Methods: HIV-negative adults aged 18–60 years were evaluated in a prospective study of RISK11 a...

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Targeted Gene Expression Profiling of Human Myeloid Cells From Blood and Lung Compartments of Patients With Tuberculosis and Other Lung Diseases

Publication Type: Academic Journal

Source(s): Frontiers in Immunology, Vol 13 (2022)

Abstract: Myeloid-derived suppressor cells (MDSC) have been identified in the peripheral blood and granulomas of patients with active TB disease, but their phenotype-, function-, and immunosuppressive mechanism- spectrum remains unclear. Importantly, the frequen...

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Diagnostic accuracy of plasma kynurenine/tryptophan ratio, measured by enzyme-linked immunosorbent assay, for pulmonary tuberculosis

Publication Type: Academic Journal

Source(s): International Journal of Infectious Diseases, Vol 99, Iss , Pp 441-448 (2020)

Abstract: Introduction: The World Health Organization has identified the need for a non-sputum-based test capable of detecting active tuberculosis (TB) as a priority. The plasma kynurenine-to-tryptophan (K/T) ratio, largely mediated by activity of the enzyme ind...

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Validation of a host blood transcriptomic biomarker for pulmonary tuberculosis in people living with HIV: a prospective diagnostic and prognostic accuracy study

Publication Type: Academic Journal

Source(s): The Lancet Global Health, Vol 9, Iss 6, Pp e841-e853 (2021)

Abstract: Summary: Background: A rapid, blood-based triage test that allows targeted investigation for tuberculosis at the point of care could shorten the time to tuberculosis treatment and reduce mortality. We aimed to test the performance of a host blood trans...

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Inflammatory Determinants of Differential Tuberculosis Risk in Pre-Adolescent Children and Young Adults

Publication Type: Academic Journal

Source(s): Frontiers in Immunology, Vol 12 (2021)

Abstract: The risk of progression from Mycobacterium tuberculosis (M.tb) infection to active tuberculosis (TB) disease varies markedly with age. TB disease is significantly less likely in pre-adolescent children above 4 years of age than in very young children o...

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Host transcriptomic signatures of tuberculosis can predict immune reconstitution inflammatory syndrome in HIV patients.

Publication Type: Academic Journal

Source(s): European Journal of Immunology; Jul2022, Vol. 52 Issue 7, p1112-1119, 8p

Abstract: Copyright of European Journal of Immunology is the property of John Wiley & Sons, Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may ...

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Performance of diagnostic and predictive host blood transcriptomic signatures for Tuberculosis disease: A systematic review and meta-analysis.

Publication Type: Academic Journal

Source(s): PLoS ONE, Vol 15, Iss 8, p e0237574 (2020)

Abstract: IntroductionHost blood transcriptomic biomarkers have potential as rapid point-of-care triage, diagnostic, and predictive tests for Tuberculosis disease. We aimed to summarise the performance of host blood transcriptomic signatures for diagnosis of and...

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