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Synthesis and Biological Activity of N -acyl Anabasine and Cytisine Derivatives with Adamantane, Pyridine and 1,2-Azole Fragments.
Publication Type: Academic Journal
Source(s): Molecules (Basel, Switzerland) [Molecules] 2022 Oct 31; Vol. 27 (21). Date of Electronic Publication: 2022 Oct 31.
Abstract: A series of N -acyl derivatives of anabasine and cytisine were prepared, to discover novel, natural product-based medicinal agents. All synthesized compounds were tested for antimicrobial, antifungal, antiviral and analgesic activity. The most pronounc...
Quinine Esters with 1,2-Azole, Pyridine and Adamantane Fragments.
Publication Type: Academic Journal
Source(s): Molecules (Basel, Switzerland) [Molecules] 2022 May 27; Vol. 27 (11). Date of Electronic Publication: 2022 May 27.
Abstract: An efficient method of producing quinine derivatives via reaction of acylation with 4,5-dichloroisothiazole-3-, 5-arylisoxazole-3-, adamantane- and hydrochlorides of pyridine-3- and pyridine-4-carbonyl chlorides was developed. All synthesized compounds...
Crystal structure and Hirshfeld surface analysis of 5-(5-phenyl-1,2-oxazol-3-yl)-1,3,4-thia-diazol-2-amine.
Publication Type: Academic Journal
Source(s): Acta crystallographica. Section E, Crystallographic communications [Acta Crystallogr E Crystallogr Commun] 2022 Mar 31; Vol. 78 (Pt 4), pp. 453-457. Date of Electronic Publication: 2022 Mar 31 (Print Publication: 2022).
Abstract: The title compound, C 11 H 8 N 4 OS, crystallizes with two independent mol-ecules in the asymmetric unit. In the crystal, the N-H⋯N and C-H⋯N hydrogen bonds connect the mol-ecules, generating double layers parallel to the (001) plane. The layers are jo...
Mimics of Pincer Ligands: An Accessible Phosphine-Free N -(Pyrimidin-2-yl)-1,2-azole-3-carboxamide Framework for Binuclear Pd(II) Complexes and High-Turnover Catalysis in Water.
Publication Type: Academic Journal
Source(s): Inorganic chemistry [Inorg Chem] 2020 Aug 03; Vol. 59 (15), pp. 10384-10388. Date of Electronic Publication: 2020 Jul 20.
Abstract: We report for the first time cyclic phosphine-free "head to tail" N,N,N pincer-like (pincer complexes mimicking) N -(pyrimidin-2-yl)-1,2-azole-3-carboxamide Pd(II) complexes with deprotonated amide groups as high-turnover catalysts (TON up to 10 6 , TO...
The influence of heterocyclic compound-PAMAM dendrimer complexes on evoked electrical responses in slices of hypoxic brain tissue.
Publication Type: Academic Journal
Source(s): Cellular & molecular biology letters [Cell Mol Biol Lett] 2014 Jun; Vol. 19 (2), pp. 243-8. Date of Electronic Publication: 2014 Apr 24.
Abstract: We used complexes between a fourth generation polyamidoamine (PAMAM) dendrimer and one of two heterocyclic compounds - 1-(6-hydroxyhexyl)-3-(5-phenyl-isoxazole-3-yl)-urea or 5-phenyl-isoxazole-3-carboxylic acid - to reduce oxygen consumption in transve...
Cytotoxic effects of chemotherapeutic drugs and heterocyclic compounds at application on the cells of primary culture of neuroepithelium tumors.
Publication Type: Academic Journal
Source(s): Medicinal chemistry (Shariqah (United Arab Emirates)) [Med Chem] 2012 Jan; Vol. 8 (1), pp. 22-32.
Abstract: Neuroepithelial tumor cells were cultured in vitro. The biopsy material was taken from 93 children at removal of the brain tumors during neurosurgical operations. The individual features of the cells sensitivity of primary cultures in respect to protoc...