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Advanced Search Results For "Pirooznia, Mehdi Pirooznia"

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 "Pirooznia, Mehdi Pirooznia"
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Assessing reproducibility of inherited variants detected with short-read whole genome sequencing

Publication Type: Academic Journal

Source(s): Genome Biology, Vol 23, Iss 1, Pp 1-26 (2022)

Abstract: Abstract Background Reproducible detection of inherited variants with whole genome sequencing (WGS) is vital for the implementation of precision medicine and is a complicated process in which each step affects variant call quality. Systematically asses...

Boosting NAD+ blunts TLR4-induced type I IFN in control and systemic lupus erythematosus monocytes

Publication Type: Academic Journal

Source(s): The Journal of Clinical Investigation, Vol 132, Iss 5 (2022)

Abstract: BACKGROUND Fasting and NAD+-boosting compounds, including NAD+ precursor nicotinamide riboside (NR), confer antiinflammatory effects. However, the underlying mechanisms and therapeutic potential are incompletely defined.METHODS We explored the underlyi...

A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency

Publication Type: Academic Journal

Source(s): Genome Biology, Vol 22, Iss 1, Pp 1-38 (2021)

Abstract: Abstract Background Oncopanel genomic testing, which identifies important somatic variants, is increasingly common in medical practice and especially in clinical trials. Currently, there is a paucity of reliable genomic reference samples having a suita...

Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions

Publication Type: Academic Journal

Source(s): Genome Biology, Vol 22, Iss 1, Pp 1-23 (2021)

Abstract: Abstract Background Targeted sequencing using oncopanels requires comprehensive assessments of accuracy and detection sensitivity to ensure analytical validity. By employing reference materials characterized by the U.S. Food and Drug Administration-led...

Olfactomedin 4 mediation of prostate stem/progenitor-like cell proliferation and differentiation via MYC

Publication Type: Academic Journal

Source(s): Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)

Abstract: Abstract Olfactomedin 4 (OLFM4) is expressed in normal prostate epithelial cells and immortalized normal human prostate epithelial cells (RWPE1), but the identity of OLFM4-expressing cells within these populations and OLFM4’s physiological functions in...

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Early Myeloid Derived Suppressor Cells (eMDSCs) Are Associated With High Donor Myeloid Chimerism Following Haploidentical HSCT for Sickle Cell Disease

Publication Type: Academic Journal

Source(s): Frontiers in Immunology, Vol 12 (2021)

Abstract: Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is a widely available curative option for patients with sickle cell disease (SCD). Our original non-myeloablative haplo-HSCT trial employing post-transplant (PT) cyclophosphamide had a...

Cell-free DNA maps COVID-19 tissue injury and risk of death and can cause tissue injury

Publication Type: Academic Journal

Source(s): JCI Insight, Vol 6, Iss 7 (2021)

Abstract: INTRODUCTION The clinical course of coronavirus 2019 (COVID-19) is heterogeneous, ranging from mild to severe multiorgan failure and death. In this study, we analyzed cell-free DNA (cfDNA) as a biomarker of injury to define the sources of tissue injury...

Network Analysis and Transcriptome Profiling Identify Autophagic and Mitochondrial Dysfunctions in SARS-CoV-2 Infection

Publication Type: Academic Journal

Source(s): Frontiers in Genetics, Vol 12 (2021)

Abstract: Analyzing host cells' transcriptional response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection will help delineate biological processes underlying viral pathogenesis. First, analysis of expression profiles of lung cell lines A...

In vivo functional analysis of non-conserved human lncRNAs associated with cardiometabolic traits

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

Abstract: Majority of human long non-coding RNAs (lncRNAs) are not conserved in mouse. Here the authors identify metabolic trait-associated lncRNA genes and show a functional role of a non-conserved human lncRNA, LINC01018, in lipid metabolism using a humanized ...

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