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Advanced Search Results For "Pirooznia, Mehdi Pirooznia"

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 "Pirooznia, Mehdi Pirooznia"
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Assessing reproducibility of inherited variants detected with short-read whole genome sequencing

Publication Type: Academic Journal

Source(s): Genome Biology, Vol 23, Iss 1, Pp 1-26 (2022)

Abstract: Abstract Background Reproducible detection of inherited variants with whole genome sequencing (WGS) is vital for the implementation of precision medicine and is a complicated process in which each step affects variant call quality. Systematically asses...

Boosting NAD+ blunts TLR4-induced type I IFN in control and systemic lupus erythematosus monocytes

Publication Type: Academic Journal

Source(s): The Journal of Clinical Investigation, Vol 132, Iss 5 (2022)

Abstract: BACKGROUND Fasting and NAD+-boosting compounds, including NAD+ precursor nicotinamide riboside (NR), confer antiinflammatory effects. However, the underlying mechanisms and therapeutic potential are incompletely defined.METHODS We explored the underlyi...

A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency

Publication Type: Academic Journal

Source(s): Genome Biology, Vol 22, Iss 1, Pp 1-38 (2021)

Abstract: Abstract Background Oncopanel genomic testing, which identifies important somatic variants, is increasingly common in medical practice and especially in clinical trials. Currently, there is a paucity of reliable genomic reference samples having a suita...

Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions

Publication Type: Academic Journal

Source(s): Genome Biology, Vol 22, Iss 1, Pp 1-23 (2021)

Abstract: Abstract Background Targeted sequencing using oncopanels requires comprehensive assessments of accuracy and detection sensitivity to ensure analytical validity. By employing reference materials characterized by the U.S. Food and Drug Administration-led...

Olfactomedin 4 mediation of prostate stem/progenitor-like cell proliferation and differentiation via MYC

Publication Type: Academic Journal

Source(s): Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)

Abstract: Abstract Olfactomedin 4 (OLFM4) is expressed in normal prostate epithelial cells and immortalized normal human prostate epithelial cells (RWPE1), but the identity of OLFM4-expressing cells within these populations and OLFM4’s physiological functions in...


Early Myeloid Derived Suppressor Cells (eMDSCs) Are Associated With High Donor Myeloid Chimerism Following Haploidentical HSCT for Sickle Cell Disease

Publication Type: Academic Journal

Source(s): Frontiers in Immunology, Vol 12 (2021)

Abstract: Haploidentical hematopoietic stem cell transplantation (haplo-HSCT) is a widely available curative option for patients with sickle cell disease (SCD). Our original non-myeloablative haplo-HSCT trial employing post-transplant (PT) cyclophosphamide had a...

Cell-free DNA maps COVID-19 tissue injury and risk of death and can cause tissue injury

Publication Type: Academic Journal

Source(s): JCI Insight, Vol 6, Iss 7 (2021)

Abstract: INTRODUCTION The clinical course of coronavirus 2019 (COVID-19) is heterogeneous, ranging from mild to severe multiorgan failure and death. In this study, we analyzed cell-free DNA (cfDNA) as a biomarker of injury to define the sources of tissue injury...

Network Analysis and Transcriptome Profiling Identify Autophagic and Mitochondrial Dysfunctions in SARS-CoV-2 Infection

Publication Type: Academic Journal

Source(s): Frontiers in Genetics, Vol 12 (2021)

Abstract: Analyzing host cells' transcriptional response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection will help delineate biological processes underlying viral pathogenesis. First, analysis of expression profiles of lung cell lines A...

In vivo functional analysis of non-conserved human lncRNAs associated with cardiometabolic traits

Publication Type: Academic Journal

Source(s): Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

Abstract: Majority of human long non-coding RNAs (lncRNAs) are not conserved in mouse. Here the authors identify metabolic trait-associated lncRNA genes and show a functional role of a non-conserved human lncRNA, LINC01018, in lipid metabolism using a humanized ...