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Identifying the Common Genetic Basis of Antidepressant Response
Publication Type: Academic Journal
Source(s): Biological Psychiatry Global Open Science, Vol 2, Iss 2, Pp 115-126 (2022)
Abstract: Background: Antidepressants are a first-line treatment for depression. However, only a third of individuals experience remission after the first treatment. Common genetic variation, in part, likely regulates antidepressant response, yet the success of ...
Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients
Publication Type: Academic Journal
Source(s): Translational Psychiatry, Vol 11, Iss 1, Pp 1-8 (2021)
Abstract: Abstract Lithium is the gold standard therapy for Bipolar Disorder (BD) but its effectiveness differs widely between individuals. The molecular mechanisms underlying treatment response heterogeneity are not well understood, and personalized treatment i...
HLA-DRB1 and HLA-DQB1 genetic diversity modulates response to lithium in bipolar affective disorders
Publication Type: Academic Journal
Source(s): Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract: Abstract Bipolar affective disorder (BD) is a severe psychiatric illness, for which lithium (Li) is the gold standard for acute and maintenance therapies. The therapeutic response to Li in BD is heterogeneous and reliable biomarkers allowing patients s...
Correction: Combining schizophrenia and depression polygenic risk scores improves the genetic prediction of lithium response in bipolar disorder patients
Publication Type: Academic Journal
Source(s): Translational Psychiatry, Vol 12, Iss 1, Pp 1-1 (2022)
Fluoxetine and environmental enrichment similarly reverse chronic social stress-related depression- and anxiety-like behavior, but have differential effects on amygdala gene expression
Publication Type: Academic Journal
Source(s): Neurobiology of Stress, Vol 15, Iss , Pp 100392- (2021)
Abstract: The adverse effects of stress on brain and behavior have long been known and well-studied, with abundant evidence linking stress to, among other things, mood and anxiety disorders. Likewise, many have investigated potential treatments for stress-relate...
A Machine Learning Approach to Predicting Autism Risk Genes: Validation of Known Genes and Discovery of New Candidates
Publication Type: Academic Journal
Source(s): Frontiers in Genetics, Vol 11 (2020)
Abstract: Autism spectrum disorder (ASD) is a complex neurodevelopmental condition with a strong genetic basis. The role of de novo mutations in ASD has been well established, but the set of genes implicated to date is still far from complete. The current study ...
Deep learning predicts DNA methylation regulatory variants in the human brain and elucidates the genetics of psychiatric disorders.
Publication Type: Academic Journal
Source(s): Proceedings of the National Academy of Sciences of the United States of America; 8/23/2022, Vol. 119 Issue 34, p1-11, 145p
Abstract: Copyright of Proceedings of the National Academy of Sciences of the United States of America is the property of National Academy of Sciences and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright ho...
Affected Sib-Pair Analyses Identify Signaling Networks Associated With Social Behavioral Deficits in Autism
Publication Type: Academic Journal
Source(s): Frontiers in Genetics, Vol 10 (2019)
Abstract: Autism spectrum disorders (ASDs) are characterized by deficits in three core behavioral domains: reciprocal social interactions, communication, and restricted interests and/or repetitive behaviors. Several hundreds of risk genes for autism have been id...
Genetic Overlap Between Alzheimer’s Disease and Bipolar Disorder Implicates the MARK2 and VAC14 Genes
Publication Type: Academic Journal
Source(s): Frontiers in Neuroscience, Vol 13 (2019)
Abstract: Background: Alzheimer’s disease (AD) and bipolar disorder (BIP) are complex traits influenced by numerous common genetic variants, most of which remain to be detected. Clinical and epidemiological evidence suggest that AD and BIP are related. However, ...
Identifying the Common Genetic Basis of Antidepressant Response
Publication Type: Periodical
Source(s): Biological Psychiatry Global Open Science; April 2022, Vol. 2 Issue: 2 p115-126, 12p
Abstract: Antidepressants are a first-line treatment for depression. However, only a third of individuals experience remission after the first treatment. Common genetic variation, in part, likely regulates antidepressant response, yet the success of previous gen...